Reactome | psmc2 [nucleoplasm]

psmc2 [nucleoplasm]

Stable Identifier

R-DRE-174332

Type

Protein [EntityWithAccessionedSequence]

Species

Danio rerio

Compartment

nucleoplasm

Synonyms

PSMC2, Q7T3B1

Locations in the PathwayBrowser

Expand all

Cell Cycle (Danio rerio)

- Cell Cycle Checkpoints (Danio rerio)
  - G1/S DNA Damage Checkpoints (Danio rerio)
    - p53-Independent G1/S DNA Damage Checkpoint (Danio rerio)
      - Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A (Danio rerio)
        
        Proteolytic degradation of ubiquitinated-Cdc25A (Danio rerio)
        
        26S proteasome [nucleoplasm] (Danio rerio)
        
        19S regulatory particle [nucleoplasm] (Danio rerio)
        
        19S RP base [nucleoplasm] (Danio rerio)
        
        PSMC2:PSMC1:PSMD2 [nucleoplasm] (Danio rerio)
        
        PSMC2:PSMC1 [nucleoplasm] (Danio rerio)
        
        psmc2 [nucleoplasm] (Danio rerio)
- Cell Cycle, Mitotic (Danio rerio)
  - Mitotic G1 phase and G1/S transition (Danio rerio)
    - G1/S Transition (Danio rerio)
      - Cyclin E associated events during G1/S transition (Danio rerio)
        
        SCF(Skp2)-mediated degradation of p27/p21 (Danio rerio)
        
        Degradation of ubiquitinated p27/p21 by the 26S proteasome (Danio rerio)
        
        26S proteasome [nucleoplasm] (Danio rerio)
        
        19S regulatory particle [nucleoplasm] (Danio rerio)
        
        19S RP base [nucleoplasm] (Danio rerio)
        
        PSMC2:PSMC1:PSMD2 [nucleoplasm] (Danio rerio)
        
        PSMC2:PSMC1 [nucleoplasm] (Danio rerio)
        
        psmc2 [nucleoplasm] (Danio rerio)
  - Regulation of mitotic cell cycle (Danio rerio)
    - APC/C-mediated degradation of cell cycle proteins (Danio rerio)
      - APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 (Danio rerio)
        
        APC/C:Cdh1-mediated degradation of Skp2 (Danio rerio)
        
        26S proteasome [nucleoplasm] (Danio rerio)
        
        19S regulatory particle [nucleoplasm] (Danio rerio)
        
        19S RP base [nucleoplasm] (Danio rerio)
        
        PSMC2:PSMC1:PSMD2 [nucleoplasm] (Danio rerio)
        
        PSMC2:PSMC1 [nucleoplasm] (Danio rerio)
        
        psmc2 [nucleoplasm] (Danio rerio)
      - Autodegradation of Cdh1 by Cdh1:APC/C (Danio rerio)
        
        Degradation of multiubiquitinated Cdh1 (Danio rerio)
        
        26S proteasome [nucleoplasm] (Danio rerio)
        
        19S regulatory particle [nucleoplasm] (Danio rerio)
        
        19S RP base [nucleoplasm] (Danio rerio)
        
        PSMC2:PSMC1:PSMD2 [nucleoplasm] (Danio rerio)
        
        PSMC2:PSMC1 [nucleoplasm] (Danio rerio)
        
        psmc2 [nucleoplasm] (Danio rerio)
  - S Phase (Danio rerio)
    - Cyclin A:Cdk2-associated events at S phase entry (Danio rerio)
      - SCF(Skp2)-mediated degradation of p27/p21 (Danio rerio)
        
        Degradation of ubiquitinated p27/p21 by the 26S proteasome (Danio rerio)
        
        26S proteasome [nucleoplasm] (Danio rerio)
        
        19S regulatory particle [nucleoplasm] (Danio rerio)
        
        19S RP base [nucleoplasm] (Danio rerio)
        
        PSMC2:PSMC1:PSMD2 [nucleoplasm] (Danio rerio)
        
        PSMC2:PSMC1 [nucleoplasm] (Danio rerio)
        
        psmc2 [nucleoplasm] (Danio rerio)

Cellular responses to stimuli (Danio rerio)

- Cellular responses to stress (Danio rerio)
  - Cellular response to chemical stress (Danio rerio)
    - KEAP1-NFE2L2 pathway (Danio rerio)
      - Nuclear events mediated by NFE2L2 (Danio rerio)
        
        GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 (Danio rerio)
        
        Ub,pS335,S338,T NFE2L2 is degraded (Danio rerio)
        
        26S proteasome [nucleoplasm] (Danio rerio)
        
        19S regulatory particle [nucleoplasm] (Danio rerio)
        
        19S RP base [nucleoplasm] (Danio rerio)
        
        PSMC2:PSMC1:PSMD2 [nucleoplasm] (Danio rerio)
        
        PSMC2:PSMC1 [nucleoplasm] (Danio rerio)
        
        psmc2 [nucleoplasm] (Danio rerio)

DNA Replication (Danio rerio)

- DNA Replication Pre-Initiation (Danio rerio)
  - Assembly of the pre-replicative complex (Danio rerio)
    - Ubiquitinated geminin is degraded by the proteasome (Danio rerio)
      - 26S proteasome [nucleoplasm] (Danio rerio)
        
        19S regulatory particle [nucleoplasm] (Danio rerio)
        
        19S RP base [nucleoplasm] (Danio rerio)
        
        PSMC2:PSMC1:PSMD2 [nucleoplasm] (Danio rerio)
        
        PSMC2:PSMC1 [nucleoplasm] (Danio rerio)
        
        psmc2 [nucleoplasm] (Danio rerio)

Gene expression (Transcription) (Danio rerio)

- RNA Polymerase II Transcription (Danio rerio)
  - Generic Transcription Pathway (Danio rerio)
    - Transcriptional regulation by RUNX2 (Danio rerio)
      - Regulation of RUNX2 expression and activity (Danio rerio)
        
        26S proteasome degrades PolyUb-RUNX2 (Danio rerio)
        
        26S proteasome [nucleoplasm] (Danio rerio)
        
        19S regulatory particle [nucleoplasm] (Danio rerio)
        
        19S RP base [nucleoplasm] (Danio rerio)
        
        PSMC2:PSMC1:PSMD2 [nucleoplasm] (Danio rerio)
        
        PSMC2:PSMC1 [nucleoplasm] (Danio rerio)
        
        psmc2 [nucleoplasm] (Danio rerio)
    - Transcriptional regulation by RUNX3 (Danio rerio)
      - Regulation of RUNX3 expression and activity (Danio rerio)
        
        Polyubiquitinated RUNX3 is degraded by the proteasome (Danio rerio)
        
        26S proteasome [nucleoplasm] (Danio rerio)
        
        19S regulatory particle [nucleoplasm] (Danio rerio)
        
        19S RP base [nucleoplasm] (Danio rerio)
        
        PSMC2:PSMC1:PSMD2 [nucleoplasm] (Danio rerio)
        
        PSMC2:PSMC1 [nucleoplasm] (Danio rerio)
        
        psmc2 [nucleoplasm] (Danio rerio)

Signal Transduction (Danio rerio)

- Signaling by Hedgehog (Danio rerio)
  - Hedgehog 'on' state (Danio rerio)
    - GLI2,3 are degraded by the proteasome (Danio rerio)
      - 26S proteasome [nucleoplasm] (Danio rerio)
        
        19S regulatory particle [nucleoplasm] (Danio rerio)
        
        19S RP base [nucleoplasm] (Danio rerio)
        
        PSMC2:PSMC1:PSMD2 [nucleoplasm] (Danio rerio)
        
        PSMC2:PSMC1 [nucleoplasm] (Danio rerio)
        
        psmc2 [nucleoplasm] (Danio rerio)

External Reference Information

External Reference

UniProt:Q7T3B1

Gene Names

psmc2

Reference Genes

BioGPS Gene:393941 psmc2

ENSEMBL:ENSDARG00000020101

KEGG:dre:393941 psmc2

Monarch:393941 psmc2

NCBI Gene:393941 psmc2

UCSC:Q7T3B1 psmc2

Reference Transcript

RefSeq:NM_200966.1 psmc2

Other Identifiers

13181537

393941

A_15_P102890

A_15_P620121

CJ013937

CJ014336

DRER02457

Dr.7318.1.S1_at

ENSDART00000019647

ENSDART00000019647_1

ENSDART00000019647_2

GO:0005524

GO:0016787

GO:0016887

LOLS06358

MADDr01008502

NM_200966

OTTDART00000008985

Participates

as a component of

PSMC2:PSMC1 [nucleoplasm] (Danio rerio)

Other forms of this molecule

psmc2 [secretory granule lumen]

psmc2 [extracellular region]

psmc2 [ficolin-1-rich granule lumen]

psmc2 [cytosol]

Inferred From

PSMC2 [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

NP_957260.1

ENSEMBL

ENSDART00000019647, ENSDARP00000011083, ENSDARG00000020101

ZFIN

ZDB-GENE-040426-1327

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