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phospho-p-S218,S222-MAP2K1 [cytosol]
Stable Identifier
R-DRE-109837
Type
Protein [EntityWithAccessionedSequence]
Species
Danio rerio
Compartment
cytosol
Synonyms
Q4V947
Locations in the PathwayBrowser
Expand all
Developmental Biology (Danio rerio)
Nervous system development (Danio rerio)
Axon guidance (Danio rerio)
L1CAM interactions (Danio rerio)
Signal transduction by L1 (Danio rerio)
MAP2K1 phosphorylates MAPK3 (Danio rerio)
p-2S-MAP2K1:MAPK3 [cytosol] (Danio rerio)
phospho-p-S218,S222-MAP2K1 [cytosol] (Danio rerio)
p-T,Y-MAPK3:p-2S-MAP2K1 [cytosol] (Danio rerio)
phospho-p-S218,S222-MAP2K1 [cytosol] (Danio rerio)
phospho-p-S218,S222-MAP2K1 [cytosol] (Danio rerio)
Signal Transduction (Danio rerio)
MAPK family signaling cascades (Danio rerio)
MAPK1/MAPK3 signaling (Danio rerio)
RAF-independent MAPK1/3 activation (Danio rerio)
MAPK3 (ERK1) activation (Danio rerio)
Dissociation of p-T,Y-MAPK3:MAP2K1 (Danio rerio)
p-T,Y-MAPK3:p-2S-MAP2K1 [cytosol] (Danio rerio)
phospho-p-S218,S222-MAP2K1 [cytosol] (Danio rerio)
phospho-p-S218,S222-MAP2K1 [cytosol] (Danio rerio)
Inactivation of MAP2K1 by CDK1 (Danio rerio)
MAP2K1 [cytosol] (Danio rerio)
phospho-p-S218,S222-MAP2K1 [cytosol] (Danio rerio)
MAP2K1 binds MAPK3 (Danio rerio)
p-2S-MAP2K1:MAPK3 [cytosol] (Danio rerio)
phospho-p-S218,S222-MAP2K1 [cytosol] (Danio rerio)
phospho-p-S218,S222-MAP2K1 [cytosol] (Danio rerio)
MAP2K1 phosphorylates MAPK3 (Danio rerio)
p-2S-MAP2K1:MAPK3 [cytosol] (Danio rerio)
phospho-p-S218,S222-MAP2K1 [cytosol] (Danio rerio)
p-T,Y-MAPK3:p-2S-MAP2K1 [cytosol] (Danio rerio)
phospho-p-S218,S222-MAP2K1 [cytosol] (Danio rerio)
phospho-p-S218,S222-MAP2K1 [cytosol] (Danio rerio)
RAF/MAP kinase cascade (Danio rerio)
MAP2K and MAPK activation (Danio rerio)
Dual mechanism MAPK inhibitors bind MAPKs (Danio rerio)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Danio rerio)
p-2S MAP2K homo/heterodimers [cytosol] (Danio rerio)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Danio rerio)
phospho-p-S218,S222-MAP2K1 [cytosol] (Danio rerio)
p-S218,S222 MAP2K1 dimer [cytosol] (Danio rerio)
phospho-p-S218,S222-MAP2K1 [cytosol] (Danio rerio)
activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Danio rerio)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Danio rerio)
p-2S MAP2K homo/heterodimers [cytosol] (Danio rerio)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Danio rerio)
phospho-p-S218,S222-MAP2K1 [cytosol] (Danio rerio)
p-S218,S222 MAP2K1 dimer [cytosol] (Danio rerio)
phospho-p-S218,S222-MAP2K1 [cytosol] (Danio rerio)
IL17RD binds p-2S MAP2Ks and MAPKs (Danio rerio)
IL17RD:p-2S MAP2Ks:MAPKs [Golgi membrane] (Danio rerio)
p-2S MAP2K homo/heterodimers [cytosol] (Danio rerio)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Danio rerio)
phospho-p-S218,S222-MAP2K1 [cytosol] (Danio rerio)
p-S218,S222 MAP2K1 dimer [cytosol] (Danio rerio)
phospho-p-S218,S222-MAP2K1 [cytosol] (Danio rerio)
p-2S MAP2K homo/heterodimers [cytosol] (Danio rerio)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Danio rerio)
phospho-p-S218,S222-MAP2K1 [cytosol] (Danio rerio)
p-S218,S222 MAP2K1 dimer [cytosol] (Danio rerio)
phospho-p-S218,S222-MAP2K1 [cytosol] (Danio rerio)
MAP2Ks and MAPKs are phosphorylated at the endosome membrane (Danio rerio)
WDR83:LAMTOR2:LAMTOR3:activated RAF:p-2S MAP2K:p-T,Y MAPK complex [endosome membrane] (Danio rerio)
p-2S MAP2K homo/heterodimers [cytosol] (Danio rerio)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Danio rerio)
phospho-p-S218,S222-MAP2K1 [cytosol] (Danio rerio)
p-S218,S222 MAP2K1 dimer [cytosol] (Danio rerio)
phospho-p-S218,S222-MAP2K1 [cytosol] (Danio rerio)
MAP2Ks phosphorylate MAPK at the Golgi membrane (Danio rerio)
IL17RD:p-2S MAP2Ks:MAPKs [Golgi membrane] (Danio rerio)
p-2S MAP2K homo/heterodimers [cytosol] (Danio rerio)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Danio rerio)
phospho-p-S218,S222-MAP2K1 [cytosol] (Danio rerio)
p-S218,S222 MAP2K1 dimer [cytosol] (Danio rerio)
phospho-p-S218,S222-MAP2K1 [cytosol] (Danio rerio)
IL17RD:p-2S MAP2Ks:p-T,Y MAPKs [Golgi membrane] (Danio rerio)
p-2S MAP2K homo/heterodimers [cytosol] (Danio rerio)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Danio rerio)
phospho-p-S218,S222-MAP2K1 [cytosol] (Danio rerio)
p-S218,S222 MAP2K1 dimer [cytosol] (Danio rerio)
phospho-p-S218,S222-MAP2K1 [cytosol] (Danio rerio)
p-2S MAP2K homo/heterodimers [cytosol] (Danio rerio)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Danio rerio)
phospho-p-S218,S222-MAP2K1 [cytosol] (Danio rerio)
p-S218,S222 MAP2K1 dimer [cytosol] (Danio rerio)
phospho-p-S218,S222-MAP2K1 [cytosol] (Danio rerio)
MAP2Ks phosphorylate MAPKs (Danio rerio)
activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Danio rerio)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Danio rerio)
p-2S MAP2K homo/heterodimers [cytosol] (Danio rerio)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Danio rerio)
phospho-p-S218,S222-MAP2K1 [cytosol] (Danio rerio)
p-S218,S222 MAP2K1 dimer [cytosol] (Danio rerio)
phospho-p-S218,S222-MAP2K1 [cytosol] (Danio rerio)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Danio rerio)
p-2S MAP2K homo/heterodimers [cytosol] (Danio rerio)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Danio rerio)
phospho-p-S218,S222-MAP2K1 [cytosol] (Danio rerio)
p-S218,S222 MAP2K1 dimer [cytosol] (Danio rerio)
phospho-p-S218,S222-MAP2K1 [cytosol] (Danio rerio)
activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Danio rerio)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Danio rerio)
p-2S MAP2K homo/heterodimers [cytosol] (Danio rerio)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Danio rerio)
phospho-p-S218,S222-MAP2K1 [cytosol] (Danio rerio)
p-S218,S222 MAP2K1 dimer [cytosol] (Danio rerio)
phospho-p-S218,S222-MAP2K1 [cytosol] (Danio rerio)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Danio rerio)
p-2S MAP2K homo/heterodimers [cytosol] (Danio rerio)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Danio rerio)
phospho-p-S218,S222-MAP2K1 [cytosol] (Danio rerio)
p-S218,S222 MAP2K1 dimer [cytosol] (Danio rerio)
phospho-p-S218,S222-MAP2K1 [cytosol] (Danio rerio)
p-2S MAP2K homo/heterodimers [cytosol] (Danio rerio)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Danio rerio)
phospho-p-S218,S222-MAP2K1 [cytosol] (Danio rerio)
p-S218,S222 MAP2K1 dimer [cytosol] (Danio rerio)
phospho-p-S218,S222-MAP2K1 [cytosol] (Danio rerio)
RAF phosphorylates MAP2K dimer (Danio rerio)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Danio rerio)
p-2S MAP2K homo/heterodimers [cytosol] (Danio rerio)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Danio rerio)
phospho-p-S218,S222-MAP2K1 [cytosol] (Danio rerio)
p-S218,S222 MAP2K1 dimer [cytosol] (Danio rerio)
phospho-p-S218,S222-MAP2K1 [cytosol] (Danio rerio)
Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks (Danio rerio)
activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Danio rerio)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Danio rerio)
p-2S MAP2K homo/heterodimers [cytosol] (Danio rerio)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Danio rerio)
phospho-p-S218,S222-MAP2K1 [cytosol] (Danio rerio)
p-S218,S222 MAP2K1 dimer [cytosol] (Danio rerio)
phospho-p-S218,S222-MAP2K1 [cytosol] (Danio rerio)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Danio rerio)
p-2S MAP2K homo/heterodimers [cytosol] (Danio rerio)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Danio rerio)
phospho-p-S218,S222-MAP2K1 [cytosol] (Danio rerio)
p-S218,S222 MAP2K1 dimer [cytosol] (Danio rerio)
phospho-p-S218,S222-MAP2K1 [cytosol] (Danio rerio)
Single mechanism MAPK inhibitors bind phosphorylated MAPK (Danio rerio)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Danio rerio)
p-2S MAP2K homo/heterodimers [cytosol] (Danio rerio)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Danio rerio)
phospho-p-S218,S222-MAP2K1 [cytosol] (Danio rerio)
p-S218,S222 MAP2K1 dimer [cytosol] (Danio rerio)
phospho-p-S218,S222-MAP2K1 [cytosol] (Danio rerio)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK:single mechanism MAPK inhibitors [plasma membrane] (Danio rerio)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Danio rerio)
p-2S MAP2K homo/heterodimers [cytosol] (Danio rerio)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Danio rerio)
phospho-p-S218,S222-MAP2K1 [cytosol] (Danio rerio)
p-S218,S222 MAP2K1 dimer [cytosol] (Danio rerio)
phospho-p-S218,S222-MAP2K1 [cytosol] (Danio rerio)
Negative regulation of MAPK pathway (Danio rerio)
Negative feedback regulation of MAPK pathway (Danio rerio)
Activated MAPKs phosphorylate MAP2K1 (Danio rerio)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Danio rerio)
phospho-p-S218,S222-MAP2K1 [cytosol] (Danio rerio)
RAF activation (Danio rerio)
Phosphorylation of RAF (Danio rerio)
RAF activating kinases [plasma membrane] (Danio rerio)
p-2S MAP2K homo/heterodimers [cytosol] (Danio rerio)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Danio rerio)
phospho-p-S218,S222-MAP2K1 [cytosol] (Danio rerio)
p-S218,S222 MAP2K1 dimer [cytosol] (Danio rerio)
phospho-p-S218,S222-MAP2K1 [cytosol] (Danio rerio)
Signaling by Receptor Tyrosine Kinases (Danio rerio)
Signaling by NTRKs (Danio rerio)
Signaling by NTRK1 (TRKA) (Danio rerio)
Signalling to ERKs (Danio rerio)
Prolonged ERK activation events (Danio rerio)
Frs2-mediated activation (Danio rerio)
Activated BRAF phosphorylates MAP2K dimers downstream of RAP1 and NGF (Danio rerio)
RAP1:GTP:activated BRAF dimer:p-2S MAPK2K:MAPK complex [endosome membrane] (Danio rerio)
p-2S MAP2K homo/heterodimers [cytosol] (Danio rerio)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Danio rerio)
phospho-p-S218,S222-MAP2K1 [cytosol] (Danio rerio)
p-S218,S222 MAP2K1 dimer [cytosol] (Danio rerio)
phospho-p-S218,S222-MAP2K1 [cytosol] (Danio rerio)
Dissociation of phosphorylated MAP2Ks and MAPKs (Danio rerio)
RAP1:GTP:activated BRAF dimer:p-2S MAPK2K:p-T,Y MAPK complex [endosome membrane] (Danio rerio)
p-2S MAP2K homo/heterodimers [cytosol] (Danio rerio)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Danio rerio)
phospho-p-S218,S222-MAP2K1 [cytosol] (Danio rerio)
p-S218,S222 MAP2K1 dimer [cytosol] (Danio rerio)
phospho-p-S218,S222-MAP2K1 [cytosol] (Danio rerio)
p-2S MAP2K homo/heterodimers [cytosol] (Danio rerio)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Danio rerio)
phospho-p-S218,S222-MAP2K1 [cytosol] (Danio rerio)
p-S218,S222 MAP2K1 dimer [cytosol] (Danio rerio)
phospho-p-S218,S222-MAP2K1 [cytosol] (Danio rerio)
MAP2Ks phosphorylate MAPKs downstream of BRAF and NGF (Danio rerio)
RAP1:GTP:activated BRAF dimer:p-2S MAPK2K:MAPK complex [endosome membrane] (Danio rerio)
p-2S MAP2K homo/heterodimers [cytosol] (Danio rerio)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Danio rerio)
phospho-p-S218,S222-MAP2K1 [cytosol] (Danio rerio)
p-S218,S222 MAP2K1 dimer [cytosol] (Danio rerio)
phospho-p-S218,S222-MAP2K1 [cytosol] (Danio rerio)
RAP1:GTP:activated BRAF dimer:p-2S MAPK2K:p-T,Y MAPK complex [endosome membrane] (Danio rerio)
p-2S MAP2K homo/heterodimers [cytosol] (Danio rerio)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Danio rerio)
phospho-p-S218,S222-MAP2K1 [cytosol] (Danio rerio)
p-S218,S222 MAP2K1 dimer [cytosol] (Danio rerio)
phospho-p-S218,S222-MAP2K1 [cytosol] (Danio rerio)
External Reference Information
External Reference
UniProt:Q4V947
Reference Genes
BioGPS Gene:406728
ENSEMBL:ENSDARG00000007825
KEGG:dre:406728
Monarch:406728
NCBI Gene:406728
UCSC:Q4V947
Reference Transcript
RefSeq:NM_213419.2
Participates
as a member of
MAP2K1 [cytosol] (Danio rerio)
as an output of
Dissociation of p-T,Y-MAPK3:MAP2K1 (Danio rerio)
as an input of
MAP2K1 binds MAPK3 (Danio rerio)
as a component of
p-2S-MAP2K1:MAPK3 [cytosol] (Danio rerio)
p-T,Y-MAPK3:p-2S-MAP2K1 [cytosol] (Danio rerio)
p-S218,S222 MAP2K1 dimer [cytosol] (Danio rerio)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Danio rerio)
Other forms of this molecule
phospho-p-S,218, S222,T292 MAP2K1 [cytosol]
phospho-p-T286,T292-MAP2K1 [cytosol]
phospho-p-S218,S222,T286,T292-MAP2K1 [cytosol]
MAP2K1 [cytosol]
Inferred From
p-S218,S222-MAP2K1 [cytosol]
(Homo sapiens)
Modified Residues
Name
O-phospho-L-serine at 218 (in Homo sapiens)
Coordinate
218
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 222 (in Homo sapiens)
Coordinate
222
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Cross References
ZFIN
ZDB-GENE-040426-2759
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