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p-S218,S222 MAP2K1 dimer [cytosol]
Stable Identifier
R-HSA-5672703
Type
Complex
Species
Homo sapiens
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
Oncogenic MAPK signaling (Homo sapiens)
Paradoxical activation of RAF signaling by kinase inactive BRAF (Homo sapiens)
Activated MAP2Ks phosphorylate MAPKs downstream of inactive BRAF mutants (Homo sapiens)
RAS:GTP: inactive p-RAF:p-2S MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
p-2S MAP2K homo/heterodimers [cytosol] (Homo sapiens)
p-S218,S222 MAP2K1 dimer [cytosol] (Homo sapiens)
RAS:GTP:inactive p-RAF:p-2S MAP2Ks:p-T,Y MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
p-2S MAP2K homo/heterodimers [cytosol] (Homo sapiens)
p-S218,S222 MAP2K1 dimer [cytosol] (Homo sapiens)
Dissociation of paradoxically activated RAS:BRAF complexes (Homo sapiens)
RAS:GTP:inactive p-RAF:p-2S MAP2Ks:p-T,Y MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
p-2S MAP2K homo/heterodimers [cytosol] (Homo sapiens)
p-S218,S222 MAP2K1 dimer [cytosol] (Homo sapiens)
p-2S MAP2K homo/heterodimers [cytosol] (Homo sapiens)
p-S218,S222 MAP2K1 dimer [cytosol] (Homo sapiens)
RAF is paradoxically phosphorylated downstream of kinase-inactive RAF (Homo sapiens)
RAF activating kinases [plasma membrane] (Homo sapiens)
p-2S MAP2K homo/heterodimers [cytosol] (Homo sapiens)
p-S218,S222 MAP2K1 dimer [cytosol] (Homo sapiens)
RAS:GTP:inactive p-RAF complexes phosphorylate MAP2Ks (Homo sapiens)
RAS:GTP: inactive p-RAF:p-2S MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
p-2S MAP2K homo/heterodimers [cytosol] (Homo sapiens)
p-S218,S222 MAP2K1 dimer [cytosol] (Homo sapiens)
Signaling by BRAF and RAF1 fusions (Homo sapiens)
BRAF and RAF fusion mutant dimers are phosphorylated (Homo sapiens)
RAF activating kinases [plasma membrane] (Homo sapiens)
p-2S MAP2K homo/heterodimers [cytosol] (Homo sapiens)
p-S218,S222 MAP2K1 dimer [cytosol] (Homo sapiens)
Dissociation of BRAF/RAF fusion complex (Homo sapiens)
p-2S MAP2K homo/heterodimers [cytosol] (Homo sapiens)
p-S218,S222 MAP2K1 dimer [cytosol] (Homo sapiens)
p-BRAF/RAF fusion dimers:p-2S MAP2Ks:p-T,Y MAPKs:scaffold proteins [cytosol] (Homo sapiens)
p-2S MAP2K homo/heterodimers [cytosol] (Homo sapiens)
p-S218,S222 MAP2K1 dimer [cytosol] (Homo sapiens)
MAPKs are phosphorylated downstream of BRAF and RAF fusion dimers (Homo sapiens)
p-BRAF/RAF fusion dimers:p-2S MAP2Ks:MAPKs:scaffold proteins [cytosol] (Homo sapiens)
p-2S MAP2K homo/heterodimers [cytosol] (Homo sapiens)
p-S218,S222 MAP2K1 dimer [cytosol] (Homo sapiens)
p-BRAF/RAF fusion dimers:p-2S MAP2Ks:p-T,Y MAPKs:scaffold proteins [cytosol] (Homo sapiens)
p-2S MAP2K homo/heterodimers [cytosol] (Homo sapiens)
p-S218,S222 MAP2K1 dimer [cytosol] (Homo sapiens)
p-BRAF and RAF fusion dimers phosphorylate MAP2Ks (Homo sapiens)
p-BRAF/RAF fusion dimers:p-2S MAP2Ks:MAPKs:scaffold proteins [cytosol] (Homo sapiens)
p-2S MAP2K homo/heterodimers [cytosol] (Homo sapiens)
p-S218,S222 MAP2K1 dimer [cytosol] (Homo sapiens)
Signaling by RAF1 mutants (Homo sapiens)
Dissociation of RAS:RAF1 mutant complex (Homo sapiens)
activated RAF1 mutant:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Homo sapiens)
p-2S MAP2K homo/heterodimers [cytosol] (Homo sapiens)
p-S218,S222 MAP2K1 dimer [cytosol] (Homo sapiens)
p-2S MAP2K homo/heterodimers [cytosol] (Homo sapiens)
p-S218,S222 MAP2K1 dimer [cytosol] (Homo sapiens)
MAP2Ks phosphorylate MAPKs downstream of RAF1 mutants (Homo sapiens)
activated RAF1 mutant:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
p-2S MAP2K homo/heterodimers [cytosol] (Homo sapiens)
p-S218,S222 MAP2K1 dimer [cytosol] (Homo sapiens)
activated RAF1 mutant:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Homo sapiens)
p-2S MAP2K homo/heterodimers [cytosol] (Homo sapiens)
p-S218,S222 MAP2K1 dimer [cytosol] (Homo sapiens)
p-2S MAP2K homo/heterodimers [cytosol] (Homo sapiens)
p-S218,S222 MAP2K1 dimer [cytosol] (Homo sapiens)
Phosphorylation of RAF1 mutants (Homo sapiens)
RAF activating kinases [plasma membrane] (Homo sapiens)
p-2S MAP2K homo/heterodimers [cytosol] (Homo sapiens)
p-S218,S222 MAP2K1 dimer [cytosol] (Homo sapiens)
RAF1 mutant complexes phosphorylate MAP2K dimer (Homo sapiens)
activated RAF1 mutant:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
p-2S MAP2K homo/heterodimers [cytosol] (Homo sapiens)
p-S218,S222 MAP2K1 dimer [cytosol] (Homo sapiens)
Signaling by RAS mutants (Homo sapiens)
Signaling downstream of RAS mutants (Homo sapiens)
Activated MAP2Ks phosphorylate MAPKs downstream of oncogenic RAS (Homo sapiens)
mutant RAS:GTP:p-RAF:p-2S MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
p-2S MAP2K homo/heterodimers [cytosol] (Homo sapiens)
p-S218,S222 MAP2K1 dimer [cytosol] (Homo sapiens)
mutant RAS:GTP:p-RAF:p-2S MAP2Ks:p-T,Y MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
p-2S MAP2K homo/heterodimers [cytosol] (Homo sapiens)
p-S218,S222 MAP2K1 dimer [cytosol] (Homo sapiens)
Dissociation of oncogenic RAS:RAF complex (Homo sapiens)
mutant RAS:GTP:p-RAF:p-2S MAP2Ks:p-T,Y MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
p-2S MAP2K homo/heterodimers [cytosol] (Homo sapiens)
p-S218,S222 MAP2K1 dimer [cytosol] (Homo sapiens)
p-2S MAP2K homo/heterodimers [cytosol] (Homo sapiens)
p-S218,S222 MAP2K1 dimer [cytosol] (Homo sapiens)
Mutant RAS:p-RAF complexes phosphorylate MAP2Ks (Homo sapiens)
mutant RAS:GTP:p-RAF:p-2S MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
p-2S MAP2K homo/heterodimers [cytosol] (Homo sapiens)
p-S218,S222 MAP2K1 dimer [cytosol] (Homo sapiens)
RAF is phosphorylated downstream of oncogenic RAS (Homo sapiens)
RAF activating kinases [plasma membrane] (Homo sapiens)
p-2S MAP2K homo/heterodimers [cytosol] (Homo sapiens)
p-S218,S222 MAP2K1 dimer [cytosol] (Homo sapiens)
Signaling by high-kinase activity BRAF mutants (Homo sapiens)
Activated MAP2Ks phosphorylate MAPKs downstream of high kinase activity BRAF mutants (Homo sapiens)
high kinase activity BRAF mutants:scaffold:p-2S MAP2K:MAPK complex [cytosol] (Homo sapiens)
p-2S MAP2K homo/heterodimers [cytosol] (Homo sapiens)
p-S218,S222 MAP2K1 dimer [cytosol] (Homo sapiens)
high kinase activity BRAF mutants:scaffold:p-2S MAP2K:p-T,Y MAPK complex [cytosol] (Homo sapiens)
p-2S MAP2K homo/heterodimers [cytosol] (Homo sapiens)
p-S218,S222 MAP2K1 dimer [cytosol] (Homo sapiens)
Dissociation of high activity BRAF complexes (Homo sapiens)
high kinase activity BRAF mutants:scaffold:p-2S MAP2K:p-T,Y MAPK complex [cytosol] (Homo sapiens)
p-2S MAP2K homo/heterodimers [cytosol] (Homo sapiens)
p-S218,S222 MAP2K1 dimer [cytosol] (Homo sapiens)
p-2S MAP2K homo/heterodimers [cytosol] (Homo sapiens)
p-S218,S222 MAP2K1 dimer [cytosol] (Homo sapiens)
High kinase activity BRAF complexes phosphorylate MAP2Ks (Homo sapiens)
high kinase activity BRAF mutants:scaffold:p-2S MAP2K:MAPK complex [cytosol] (Homo sapiens)
p-2S MAP2K homo/heterodimers [cytosol] (Homo sapiens)
p-S218,S222 MAP2K1 dimer [cytosol] (Homo sapiens)
Signaling by moderate kinase activity BRAF mutants (Homo sapiens)
Activated MAP2Ks phosphorylate MAPKs downstream of moderate kinase activity BRAF mutants (Homo sapiens)
RAS:GTP:moderate kinase activity p-RAF:p-2S MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
p-2S MAP2K homo/heterodimers [cytosol] (Homo sapiens)
p-S218,S222 MAP2K1 dimer [cytosol] (Homo sapiens)
RAS:GTP:moderate kinase activity p-RAF:p-2S MAP2Ks:p-T,Y MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
p-2S MAP2K homo/heterodimers [cytosol] (Homo sapiens)
p-S218,S222 MAP2K1 dimer [cytosol] (Homo sapiens)
Dissociation of moderate activity BRAF complexes (Homo sapiens)
RAS:GTP:moderate kinase activity p-RAF:p-2S MAP2Ks:p-T,Y MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
p-2S MAP2K homo/heterodimers [cytosol] (Homo sapiens)
p-S218,S222 MAP2K1 dimer [cytosol] (Homo sapiens)
p-2S MAP2K homo/heterodimers [cytosol] (Homo sapiens)
p-S218,S222 MAP2K1 dimer [cytosol] (Homo sapiens)
RAF is phosphorylated downstream of moderate kinase activity BRAF mutants (Homo sapiens)
RAF activating kinases [plasma membrane] (Homo sapiens)
p-2S MAP2K homo/heterodimers [cytosol] (Homo sapiens)
p-S218,S222 MAP2K1 dimer [cytosol] (Homo sapiens)
RAS:GTP:moderate kinase activity p-RAF complexes phosphorylate MAP2Ks (Homo sapiens)
RAS:GTP:moderate kinase activity p-RAF:p-2S MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
p-2S MAP2K homo/heterodimers [cytosol] (Homo sapiens)
p-S218,S222 MAP2K1 dimer [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
MAPK family signaling cascades (Homo sapiens)
MAPK1/MAPK3 signaling (Homo sapiens)
RAF/MAP kinase cascade (Homo sapiens)
MAP2K and MAPK activation (Homo sapiens)
Dissociation of RAS:RAF complex (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Homo sapiens)
p-2S MAP2K homo/heterodimers [cytosol] (Homo sapiens)
p-S218,S222 MAP2K1 dimer [cytosol] (Homo sapiens)
p-2S MAP2K homo/heterodimers [cytosol] (Homo sapiens)
p-S218,S222 MAP2K1 dimer [cytosol] (Homo sapiens)
Dual mechanism MAPK inhibitors bind MAPKs (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
p-2S MAP2K homo/heterodimers [cytosol] (Homo sapiens)
p-S218,S222 MAP2K1 dimer [cytosol] (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
p-2S MAP2K homo/heterodimers [cytosol] (Homo sapiens)
p-S218,S222 MAP2K1 dimer [cytosol] (Homo sapiens)
IL17RD binds p-2S MAP2Ks and MAPKs (Homo sapiens)
IL17RD:p-2S MAP2Ks:MAPKs [Golgi membrane] (Homo sapiens)
p-2S MAP2K homo/heterodimers [cytosol] (Homo sapiens)
p-S218,S222 MAP2K1 dimer [cytosol] (Homo sapiens)
p-2S MAP2K homo/heterodimers [cytosol] (Homo sapiens)
p-S218,S222 MAP2K1 dimer [cytosol] (Homo sapiens)
MAP2Ks and MAPKs are phosphorylated at the endosome membrane (Homo sapiens)
WDR83:LAMTOR2:LAMTOR3:activated RAF:p-2S MAP2K:p-T,Y MAPK complex [endosome membrane] (Homo sapiens)
p-2S MAP2K homo/heterodimers [cytosol] (Homo sapiens)
p-S218,S222 MAP2K1 dimer [cytosol] (Homo sapiens)
MAP2Ks phosphorylate MAPK at the Golgi membrane (Homo sapiens)
IL17RD:p-2S MAP2Ks:MAPKs [Golgi membrane] (Homo sapiens)
p-2S MAP2K homo/heterodimers [cytosol] (Homo sapiens)
p-S218,S222 MAP2K1 dimer [cytosol] (Homo sapiens)
IL17RD:p-2S MAP2Ks:p-T,Y MAPKs [Golgi membrane] (Homo sapiens)
p-2S MAP2K homo/heterodimers [cytosol] (Homo sapiens)
p-S218,S222 MAP2K1 dimer [cytosol] (Homo sapiens)
p-2S MAP2K homo/heterodimers [cytosol] (Homo sapiens)
p-S218,S222 MAP2K1 dimer [cytosol] (Homo sapiens)
MAP2Ks phosphorylate MAPKs (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
p-2S MAP2K homo/heterodimers [cytosol] (Homo sapiens)
p-S218,S222 MAP2K1 dimer [cytosol] (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
p-2S MAP2K homo/heterodimers [cytosol] (Homo sapiens)
p-S218,S222 MAP2K1 dimer [cytosol] (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
p-2S MAP2K homo/heterodimers [cytosol] (Homo sapiens)
p-S218,S222 MAP2K1 dimer [cytosol] (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Homo sapiens)
p-2S MAP2K homo/heterodimers [cytosol] (Homo sapiens)
p-S218,S222 MAP2K1 dimer [cytosol] (Homo sapiens)
p-2S MAP2K homo/heterodimers [cytosol] (Homo sapiens)
p-S218,S222 MAP2K1 dimer [cytosol] (Homo sapiens)
RAF phosphorylates MAP2K dimer (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
p-2S MAP2K homo/heterodimers [cytosol] (Homo sapiens)
p-S218,S222 MAP2K1 dimer [cytosol] (Homo sapiens)
Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
p-2S MAP2K homo/heterodimers [cytosol] (Homo sapiens)
p-S218,S222 MAP2K1 dimer [cytosol] (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
p-2S MAP2K homo/heterodimers [cytosol] (Homo sapiens)
p-S218,S222 MAP2K1 dimer [cytosol] (Homo sapiens)
Single mechanism MAPK inhibitors bind phosphorylated MAPK (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Homo sapiens)
p-2S MAP2K homo/heterodimers [cytosol] (Homo sapiens)
p-S218,S222 MAP2K1 dimer [cytosol] (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK:single mechanism MAPK inhibitors [plasma membrane] (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Homo sapiens)
p-2S MAP2K homo/heterodimers [cytosol] (Homo sapiens)
p-S218,S222 MAP2K1 dimer [cytosol] (Homo sapiens)
RAF activation (Homo sapiens)
Phosphorylation of RAF (Homo sapiens)
RAF activating kinases [plasma membrane] (Homo sapiens)
p-2S MAP2K homo/heterodimers [cytosol] (Homo sapiens)
p-S218,S222 MAP2K1 dimer [cytosol] (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by NTRKs (Homo sapiens)
Signaling by NTRK1 (TRKA) (Homo sapiens)
Signalling to ERKs (Homo sapiens)
Prolonged ERK activation events (Homo sapiens)
Frs2-mediated activation (Homo sapiens)
Activated BRAF phosphorylates MAP2K dimers downstream of RAP1 and NGF (Homo sapiens)
RAP1:GTP:activated BRAF dimer:p-2S MAPK2K:MAPK complex [endosome membrane] (Homo sapiens)
p-2S MAP2K homo/heterodimers [cytosol] (Homo sapiens)
p-S218,S222 MAP2K1 dimer [cytosol] (Homo sapiens)
Dissociation of phosphorylated MAP2Ks and MAPKs (Homo sapiens)
RAP1:GTP:activated BRAF dimer:p-2S MAPK2K:p-T,Y MAPK complex [endosome membrane] (Homo sapiens)
p-2S MAP2K homo/heterodimers [cytosol] (Homo sapiens)
p-S218,S222 MAP2K1 dimer [cytosol] (Homo sapiens)
p-2S MAP2K homo/heterodimers [cytosol] (Homo sapiens)
p-S218,S222 MAP2K1 dimer [cytosol] (Homo sapiens)
MAP2Ks phosphorylate MAPKs downstream of BRAF and NGF (Homo sapiens)
RAP1:GTP:activated BRAF dimer:p-2S MAPK2K:MAPK complex [endosome membrane] (Homo sapiens)
p-2S MAP2K homo/heterodimers [cytosol] (Homo sapiens)
p-S218,S222 MAP2K1 dimer [cytosol] (Homo sapiens)
RAP1:GTP:activated BRAF dimer:p-2S MAPK2K:p-T,Y MAPK complex [endosome membrane] (Homo sapiens)
p-2S MAP2K homo/heterodimers [cytosol] (Homo sapiens)
p-S218,S222 MAP2K1 dimer [cytosol] (Homo sapiens)
Participants
components
x 2
p-S218,S222-MAP2K1 [cytosol]
(Homo sapiens)
Participates
as a member of
p-2S MAP2K homo/heterodimers [cytosol] (Homo sapiens)
Inferred To
p-S218,S222 MAP2K1 dimer [cytosol]
(Bos taurus)
p-S218,S222 MAP2K1 dimer [cytosol]
(Caenorhabditis elegans)
p-S218,S222 MAP2K1 dimer [cytosol]
(Danio rerio)
p-S218,S222 MAP2K1 dimer [cytosol]
(Dictyostelium discoideum)
p-S218,S222 MAP2K1 dimer [cytosol]
(Drosophila melanogaster)
p-S218,S222 MAP2K1 dimer [cytosol]
(Gallus gallus)
p-S218,S222 MAP2K1 dimer [cytosol]
(Mus musculus)
p-S218,S222 MAP2K1 dimer [cytosol]
(Rattus norvegicus)
p-S218,S222 MAP2K1 dimer [cytosol]
(Saccharomyces cerevisiae)
p-S218,S222 MAP2K1 dimer [cytosol]
(Schizosaccharomyces pombe)
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