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phospho-Dsor1 [cytosol]
Stable Identifier
R-DME-109837
Type
Protein [EntityWithAccessionedSequence]
Species
Drosophila melanogaster
Compartment
cytosol
Synonyms
p-S218,S222-MAP2K1, Q24324
Locations in the PathwayBrowser
Expand all
Developmental Biology (Drosophila melanogaster)
Nervous system development (Drosophila melanogaster)
Axon guidance (Drosophila melanogaster)
L1CAM interactions (Drosophila melanogaster)
Signal transduction by L1 (Drosophila melanogaster)
MAP2K1 phosphorylates MAPK3 (Drosophila melanogaster)
p-2S-MAP2K1:MAPK3 [cytosol] (Drosophila melanogaster)
phospho-Dsor1 [cytosol] (Drosophila melanogaster)
p-T,Y-MAPK3:p-2S-MAP2K1 [cytosol] (Drosophila melanogaster)
phospho-Dsor1 [cytosol] (Drosophila melanogaster)
phospho-Dsor1 [cytosol] (Drosophila melanogaster)
Signal Transduction (Drosophila melanogaster)
MAPK family signaling cascades (Drosophila melanogaster)
MAPK1/MAPK3 signaling (Drosophila melanogaster)
RAF-independent MAPK1/3 activation (Drosophila melanogaster)
MAPK3 (ERK1) activation (Drosophila melanogaster)
Dissociation of p-T,Y-MAPK3:MAP2K1 (Drosophila melanogaster)
p-T,Y-MAPK3:p-2S-MAP2K1 [cytosol] (Drosophila melanogaster)
phospho-Dsor1 [cytosol] (Drosophila melanogaster)
phospho-Dsor1 [cytosol] (Drosophila melanogaster)
Inactivation of MAP2K1 by CDK1 (Drosophila melanogaster)
MAP2K1 [cytosol] (Drosophila melanogaster)
phospho-Dsor1 [cytosol] (Drosophila melanogaster)
MAP2K1 binds MAPK3 (Drosophila melanogaster)
p-2S-MAP2K1:MAPK3 [cytosol] (Drosophila melanogaster)
phospho-Dsor1 [cytosol] (Drosophila melanogaster)
phospho-Dsor1 [cytosol] (Drosophila melanogaster)
MAP2K1 phosphorylates MAPK3 (Drosophila melanogaster)
p-2S-MAP2K1:MAPK3 [cytosol] (Drosophila melanogaster)
phospho-Dsor1 [cytosol] (Drosophila melanogaster)
p-T,Y-MAPK3:p-2S-MAP2K1 [cytosol] (Drosophila melanogaster)
phospho-Dsor1 [cytosol] (Drosophila melanogaster)
phospho-Dsor1 [cytosol] (Drosophila melanogaster)
RAF/MAP kinase cascade (Drosophila melanogaster)
MAP2K and MAPK activation (Drosophila melanogaster)
Dual mechanism MAPK inhibitors bind MAPKs (Drosophila melanogaster)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Drosophila melanogaster)
p-2S MAP2K homo/heterodimers [cytosol] (Drosophila melanogaster)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Drosophila melanogaster)
phospho-Dsor1 [cytosol] (Drosophila melanogaster)
p-S218,S222 MAP2K1 dimer [cytosol] (Drosophila melanogaster)
phospho-Dsor1 [cytosol] (Drosophila melanogaster)
activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Drosophila melanogaster)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Drosophila melanogaster)
p-2S MAP2K homo/heterodimers [cytosol] (Drosophila melanogaster)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Drosophila melanogaster)
phospho-Dsor1 [cytosol] (Drosophila melanogaster)
p-S218,S222 MAP2K1 dimer [cytosol] (Drosophila melanogaster)
phospho-Dsor1 [cytosol] (Drosophila melanogaster)
MAP2Ks and MAPKs are phosphorylated at the endosome membrane (Drosophila melanogaster)
WDR83:LAMTOR2:LAMTOR3:activated RAF:p-2S MAP2K:p-T,Y MAPK complex [endosome membrane] (Drosophila melanogaster)
p-2S MAP2K homo/heterodimers [cytosol] (Drosophila melanogaster)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Drosophila melanogaster)
phospho-Dsor1 [cytosol] (Drosophila melanogaster)
p-S218,S222 MAP2K1 dimer [cytosol] (Drosophila melanogaster)
phospho-Dsor1 [cytosol] (Drosophila melanogaster)
MAP2Ks phosphorylate MAPK at the Golgi membrane (Drosophila melanogaster)
IL17RD:p-2S MAP2Ks:MAPKs [Golgi membrane] (Drosophila melanogaster)
p-2S MAP2K homo/heterodimers [cytosol] (Drosophila melanogaster)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Drosophila melanogaster)
phospho-Dsor1 [cytosol] (Drosophila melanogaster)
p-S218,S222 MAP2K1 dimer [cytosol] (Drosophila melanogaster)
phospho-Dsor1 [cytosol] (Drosophila melanogaster)
IL17RD:p-2S MAP2Ks:p-T,Y MAPKs [Golgi membrane] (Drosophila melanogaster)
p-2S MAP2K homo/heterodimers [cytosol] (Drosophila melanogaster)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Drosophila melanogaster)
phospho-Dsor1 [cytosol] (Drosophila melanogaster)
p-S218,S222 MAP2K1 dimer [cytosol] (Drosophila melanogaster)
phospho-Dsor1 [cytosol] (Drosophila melanogaster)
p-2S MAP2K homo/heterodimers [cytosol] (Drosophila melanogaster)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Drosophila melanogaster)
phospho-Dsor1 [cytosol] (Drosophila melanogaster)
p-S218,S222 MAP2K1 dimer [cytosol] (Drosophila melanogaster)
phospho-Dsor1 [cytosol] (Drosophila melanogaster)
MAP2Ks phosphorylate MAPKs (Drosophila melanogaster)
activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Drosophila melanogaster)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Drosophila melanogaster)
p-2S MAP2K homo/heterodimers [cytosol] (Drosophila melanogaster)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Drosophila melanogaster)
phospho-Dsor1 [cytosol] (Drosophila melanogaster)
p-S218,S222 MAP2K1 dimer [cytosol] (Drosophila melanogaster)
phospho-Dsor1 [cytosol] (Drosophila melanogaster)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Drosophila melanogaster)
p-2S MAP2K homo/heterodimers [cytosol] (Drosophila melanogaster)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Drosophila melanogaster)
phospho-Dsor1 [cytosol] (Drosophila melanogaster)
p-S218,S222 MAP2K1 dimer [cytosol] (Drosophila melanogaster)
phospho-Dsor1 [cytosol] (Drosophila melanogaster)
activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Drosophila melanogaster)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Drosophila melanogaster)
p-2S MAP2K homo/heterodimers [cytosol] (Drosophila melanogaster)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Drosophila melanogaster)
phospho-Dsor1 [cytosol] (Drosophila melanogaster)
p-S218,S222 MAP2K1 dimer [cytosol] (Drosophila melanogaster)
phospho-Dsor1 [cytosol] (Drosophila melanogaster)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Drosophila melanogaster)
p-2S MAP2K homo/heterodimers [cytosol] (Drosophila melanogaster)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Drosophila melanogaster)
phospho-Dsor1 [cytosol] (Drosophila melanogaster)
p-S218,S222 MAP2K1 dimer [cytosol] (Drosophila melanogaster)
phospho-Dsor1 [cytosol] (Drosophila melanogaster)
p-2S MAP2K homo/heterodimers [cytosol] (Drosophila melanogaster)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Drosophila melanogaster)
phospho-Dsor1 [cytosol] (Drosophila melanogaster)
p-S218,S222 MAP2K1 dimer [cytosol] (Drosophila melanogaster)
phospho-Dsor1 [cytosol] (Drosophila melanogaster)
RAF phosphorylates MAP2K dimer (Drosophila melanogaster)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Drosophila melanogaster)
p-2S MAP2K homo/heterodimers [cytosol] (Drosophila melanogaster)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Drosophila melanogaster)
phospho-Dsor1 [cytosol] (Drosophila melanogaster)
p-S218,S222 MAP2K1 dimer [cytosol] (Drosophila melanogaster)
phospho-Dsor1 [cytosol] (Drosophila melanogaster)
Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks (Drosophila melanogaster)
activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Drosophila melanogaster)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Drosophila melanogaster)
p-2S MAP2K homo/heterodimers [cytosol] (Drosophila melanogaster)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Drosophila melanogaster)
phospho-Dsor1 [cytosol] (Drosophila melanogaster)
p-S218,S222 MAP2K1 dimer [cytosol] (Drosophila melanogaster)
phospho-Dsor1 [cytosol] (Drosophila melanogaster)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Drosophila melanogaster)
p-2S MAP2K homo/heterodimers [cytosol] (Drosophila melanogaster)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Drosophila melanogaster)
phospho-Dsor1 [cytosol] (Drosophila melanogaster)
p-S218,S222 MAP2K1 dimer [cytosol] (Drosophila melanogaster)
phospho-Dsor1 [cytosol] (Drosophila melanogaster)
Single mechanism MAPK inhibitors bind phosphorylated MAPK (Drosophila melanogaster)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Drosophila melanogaster)
p-2S MAP2K homo/heterodimers [cytosol] (Drosophila melanogaster)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Drosophila melanogaster)
phospho-Dsor1 [cytosol] (Drosophila melanogaster)
p-S218,S222 MAP2K1 dimer [cytosol] (Drosophila melanogaster)
phospho-Dsor1 [cytosol] (Drosophila melanogaster)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK:single mechanism MAPK inhibitors [plasma membrane] (Drosophila melanogaster)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Drosophila melanogaster)
p-2S MAP2K homo/heterodimers [cytosol] (Drosophila melanogaster)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Drosophila melanogaster)
phospho-Dsor1 [cytosol] (Drosophila melanogaster)
p-S218,S222 MAP2K1 dimer [cytosol] (Drosophila melanogaster)
phospho-Dsor1 [cytosol] (Drosophila melanogaster)
Negative regulation of MAPK pathway (Drosophila melanogaster)
Negative feedback regulation of MAPK pathway (Drosophila melanogaster)
Activated MAPKs phosphorylate MAP2K1 (Drosophila melanogaster)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Drosophila melanogaster)
phospho-Dsor1 [cytosol] (Drosophila melanogaster)
External Reference Information
External Reference
UniProt:Q24324 Dsor1
Gene Names
Dsor1, CG15793
Chain
chain:1-396
Reference Genes
BioGPS Gene:31872 Dsor1
KEGG Gene (Drosophila melanogaster):Dmel_CG15793 Dsor1
Monarch:31872 Dsor1
NCBI Gene:31872 Dsor1
Reference Transcript
RefSeq:NM_001298115.1 Dsor1
RefSeq:NM_078543.4 Dsor1
Other Identifiers
154939_at
1626006_at
31872
GO:0000003
GO:0000166
GO:0000187
GO:0000278
GO:0000793
GO:0002376
GO:0003674
GO:0004672
GO:0004674
GO:0004708
GO:0004713
GO:0005515
GO:0005524
GO:0005575
GO:0005622
GO:0005634
GO:0005635
GO:0005694
GO:0005737
GO:0005829
GO:0006464
GO:0006468
GO:0006950
GO:0007049
GO:0007095
GO:0007165
GO:0007173
GO:0007275
GO:0007298
GO:0007362
GO:0007430
GO:0007465
GO:0007568
GO:0007623
GO:0008150
GO:0008286
GO:0008293
GO:0008340
GO:0008543
GO:0009790
GO:0009953
GO:0016301
GO:0016310
GO:0016740
GO:0018108
GO:0019899
GO:0019900
GO:0023014
GO:0030154
GO:0031098
GO:0032147
GO:0033314
GO:0040011
GO:0042386
GO:0042461
GO:0043167
GO:0043226
GO:0045500
GO:0048010
GO:0048856
GO:0048870
GO:0051607
GO:0070371
GO:0071481
Participant Of
hasMember
MAP2K1 [cytosol]
hasComponent
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol]
p-2S-MAP2K1:MAPK3 [cytosol]
p-S218,S222 MAP2K1 dimer [cytosol]
p-T,Y-MAPK3:p-2S-MAP2K1 [cytosol]
output
Dissociation of p-T,Y-MAPK3:MAP2K1
input
MAP2K1 binds MAPK3
Other forms of this molecule
DSOR1 [cytosol]
phospho-Dsor1 [cytosol]
Dsor1 [cytosol]
phospho-Dsor1 [cytosol]
Dsor1 [cytosol]
phospho-Dsor1 [cytosol]
phospho-Dsor1 [cytosol]
phospho-Dsor1 [cytosol]
Inferred From
p-S218,S222-MAP2K1 [cytosol] (Homo sapiens)
Modified Residues
Name
O-phospho-L-serine at 218 (in Homo sapiens)
Coordinate
218
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 222 (in Homo sapiens)
Coordinate
222
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Cross References
RefSeq
NP_001285044.1
,
NP_511098.1
Flybase
FBgn0010269
PRO
Q24324
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P11346 Raf
12
PHL [cytosol]
(R-DME-205713)
Phospho PHL [plasma membrane]
(R-DME-205859)
Raf [cytosol]
(R-DME-167205)
phospho-Raf [cytosol]
(R-DME-5624465)
phospho-Raf [cytosol]
(R-DME-5624469)
phospho-Raf [plasma membrane]
(R-DME-5675193)
phospho-Raf [cytosol]
(R-DME-109786)
phospho-Raf [cytosol]
(R-DME-5672639)
phospho-Raf [plasma membrane]
(R-DME-5672665)
phospho-Raf [plasma membrane]
(R-DME-5672648)
phospho-Raf [cytosol]
(R-DME-5672664)
phospho-Raf [cytosol]
(R-DME-5672646)
0.667
5
UniProt:P40417
14
rl [extracellular region]
(R-DME-6806250)
rl [azurophil granule lumen]
(R-DME-6799225)
rl [ficolin-1-rich granule lumen]
(R-DME-6800964)
phospho-rl [cytosol]
(R-DME-9635775)
phospho-rl [cytosol]
(R-DME-9635773)
phospho-rl [cytosol]
(R-DME-2422448)
rl [nucleoplasm]
(R-DME-199960)
rl [nucleoplasm]
(R-DME-73724)
rl [cytosol]
(R-DME-59284)
phospho-rl [cytosol]
(R-DME-109842)
phospho-rl [cytosol]
(R-DME-109853)
rl [cytosol]
(R-DME-59282)
phospho-rl [nucleoplasm]
(R-DME-112359)
phospho-rl [nucleoplasm]
(R-DME-112354)
0.534
3
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