MAP2K1 G128V [cytosol]

Stable Identifier
R-HSA-9652047
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
Synonyms
MEK1, Dual specificity mitogen-activated protein kinase kinase 1 (EC 2.7.1.-) (MAP kinase kinase 1) (MAPKK 1) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK1), Dual specificity mitogen-activated protein kinase kinase 1 , MAP kinase kinase 1, MAPKK 1, ERK activator kinase 1, MAPK/ERK kinase 1
MAP2K1 G128V [cytosol] icon
Locations in the PathwayBrowser
Literature References
PubMed ID Title Journal Year
24265153 The genetic landscape of clinical resistance to RAF inhibition in metastatic melanoma

Taylor-Weiner, A, Gutzmer, R, Rosenberg, M, Treacy, DJ, Goldinger, SM, Gogas, HJ, Dermatologic Cooperative Oncology Group of Germany (DeCOG), -, Van Allen, EM, Garraway, LA, Farlow, D, Trefzer, U, Egberts, F, Place, CS, McKenna, A, Gabriel, SB, Schadendorf, D, Hodis, E, Carter, SL, Kryukov, GV, Wagle, N, Whittaker, S, Johannessen, CM, Hassel, JC, Weide, B, Berking, C, Loquai, C, Zimmer, L, Getz, G, Hillen, U, Ugurel, S, Goetz, EM, Cibulskis, K, Sucker, A

Cancer Discov 2014
External Reference Information
External Reference
Gene Names
MAP2K1, MEK1, PRKMK1
Chain
chain:1-393
Other Identifiers
1130_at
11717291_a_at
11749555_a_at
11757478_s_at
16802190
1844_s_at
202670_PM_at
202670_at
3092255
3092256
3092264
3598663
3598664
3598670
3598671
3598672
3598673
3598688
3598690
3598691
3598692
3598696
3598697
3598700
3598701
3598702
5604
7984319
A_23_P20248
GE57608
GO:0000165
GO:0000166
GO:0002376
GO:0003824
GO:0004672
GO:0004674
GO:0004708
GO:0004712
GO:0004713
GO:0005078
GO:0005515
GO:0005524
GO:0005634
GO:0005737
GO:0005739
GO:0005768
GO:0005769
GO:0005770
GO:0005783
GO:0005794
GO:0005813
GO:0005815
GO:0005829
GO:0005856
GO:0005886
GO:0005925
GO:0006351
GO:0006355
GO:0006468
GO:0006935
GO:0007165
GO:0007507
GO:0008285
GO:0010628
GO:0014044
GO:0016020
GO:0016192
GO:0016301
GO:0016310
GO:0016740
GO:0021697
GO:0023052
GO:0030154
GO:0030182
GO:0030216
GO:0030295
GO:0030878
GO:0031410
GO:0032872
GO:0035987
GO:0036211
GO:0038133
GO:0042552
GO:0043226
GO:0043410
GO:0043539
GO:0044342
GO:0045893
GO:0048009
GO:0048538
GO:0048679
GO:0048856
GO:0048870
GO:0050772
GO:0060020
GO:0060090
GO:0060324
GO:0060425
GO:0060440
GO:0060502
GO:0060674
GO:0060711
GO:0070371
GO:0070374
GO:0071902
GO:0090170
GO:0090398
GO:0097110
GO:0098772
GO:0106310
GO:0140096
GO:1903226
GO:2000641
HMNXSV003018359
Hs.3446.0.A2_3p_at
ILMN_1694240
L05624_s_at
L11284_at
PH_hs_0022483
TC15000613.hg
Participates
Other forms of this molecule
Modified Residues
Name
glycine 128 replaced with L-valine
Coordinate
128
PsiMod
A protein modification that effectively converts a source amino acid residue to an L-valine.
A protein modification that effectively removes or replaces an glycine.
Disease
Name Identifier Synonyms
lung cancer DOID:1324
melanoma DOID:1909 Naevocarcinoma, melanoma, melanoma, malignant melanoma, morphology (morphologic abnormality), malignant melanoma NOS (morphologic abnormality), malignant melanoma (disorder), malignant melanoma, malignant melanoma, malignant melanoma, malignant melanoma
hematologic cancer DOID:2531 hematopoietic cancer, hematopoietic tumors, Hematologic neoplasm (disorder), Hematologic malignancy, hematopoietic neoplasm (morphologic abnormality), Hematologic malignancy (disorder), Hematological tumors, blood cancer, hematopoietic and lymphoid system tumor, malignant hematopoietic neoplasm (morphologic abnormality)
Cross References
ZINC - World Drugs
Guide to Pharmacology - Targets
OpenTargets
ZINC - FDA approved
ZINC - Substances
ZINC target
ZINC - Biogenic
PRO
ZINC - Investigational
ZINC - Metabolites
COSMIC
GeneCards
Pharos - Targets
ZINC - Predictions - Purchasable
Orphanet
Interactors (26)
Accession #Entities Entities Confidence Score Evidence (IntAct)
 UniProt:P15056 BRAF  20 0.978 63
 UniProt:P04049 RAF1  20 0.96 39
 UniProt:P10398 ARAF  4 0.855 10
 UniProt:Q8IVT5 KSR1  5 0.837 11
 UniProt:Q04917 YWHAH  1 0.837 8
 UniProt:P61981 YWHAG  1 0.837 8
 UniProt:P31946 YWHAB  1 0.788 7
 UniProt:P27348 YWHAQ  1 0.725 5
 UniProt:Q6VAB6 KSR2  1 0.643 9
 UniProt:P63104 YWHAZ  2 0.643 6
 UniProt:P62258 YWHAE  1 0.643 5
 UniProt:P36507 MAP2K2  12 0.643 5
 UniProt:P28482 MAPK1  18 0.609 2
 UniProt:Q8N9N5 BANP  1 0.556 3
 UniProt:P46937 YAP1  8 0.556 3
 UniProt:Q8WWU5-7 TCP11      0.556 3
 UniProt:Q8N9N5-2 BANP      0.556 3
 UniProt:Q9H8W4 PKHF2      0.556 3
 UniProt:Q9Y297 BTRC  2 0.556 3
 UniProt:Q86Y07 VRK2  2 0.524 2
 UniProt:Q61097  5 0.508 2
 UniProt:Q13526 PIN1  2 0.508 5
 UniProt:P27361 MAPK3  6 0.499 2
 UniProt:Q86Y07-1 VRK2      0.499 2
 UniProt:Q96S96 PEBP4      0.462 3
 UniProt:O75832 PSMD10  1 0.462 2
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