Reactome | FCGR3A-mediated phagocytosis

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FCGR3A-mediated phagocytosis Show undefined attributes

authored	[InstanceEdit:9673371] Jassal, Bijay, 2020-01-07 [InstanceEdit:9673434] Murillo, Julieth, 2020-01-07
created	[InstanceEdit:9664405] Murillo, Julieth, 2019-10-22
crossReference	[DatabaseIdentifier:12020756] Mondo:0005446
dbId	9664422
disease	[Disease:9674660] cutaneous leishmaniasis
displayName	FCGR3A-mediated phagocytosis
edited	[InstanceEdit:9673371] Jassal, Bijay, 2020-01-07 [InstanceEdit:9673290] Murillo, Julieth, 2020-01-07
eventOf	[Pathway:R-HSA-9664417] Leishmania phagocytosis - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:2132802] Fc-gamma receptor signaling pathway involved in phagocytosis
hasDiagram	true
hasEHLD	false
hasEvent	[BlackBoxEvent:R-HSA-9666433] IgG binds the surface of the amastigote form of Leishmania - Homo sapiens [Reaction:R-HSA-9664397] IgG binds LPG1G2 in the amastigote form of Leishmania - Homo sapiens [Reaction:R-HSA-9664406] IgG:Lma antigens binds FCGR3A:CD3 dimers - Homo sapiens [Reaction:R-HSA-9664275] Src phosphorylates CD3 dimers in IgG:Lma antigens:FCGR3A:CD3 dimers - Homo sapiens [Reaction:R-HSA-9664273] SYK binds IgG:Lma antigens:FCGR3A:p-CD3 dimers - Homo sapiens [Reaction:R-HSA-9664261] Src phosphorylate SYK in IgG:Leishmania surface:p-FCGR3A:SYK - Homo sapiens [Reaction:R-HSA-434637] PI(3,4,5)P3 binds VAV1,2,3 - Homo sapiens [Reaction:R-HSA-9666435] VAV1,2,3:PI(3,4,5)P3 binds p-6Y-SYK - Homo sapiens [Reaction:R-HSA-9666425] p-6Y-SYK phosphorylates VAV1,2,3 - Homo sapiens [Reaction:R-HSA-9666430] p-VAV1,2,3 exchanges GTP for GDP on RAC1:GDP - Homo sapiens [Reaction:R-HSA-9666426] CRKII:DOCK180:ELMO binds FCGR3A - Homo sapiens [Reaction:R-HSA-9666428] DOCK180 exchanges GTP for GDP on RAC1:GDP - Homo sapiens [Reaction:R-HSA-2029465] RAC1:GTP and PIP3 bind WAVE Regulatory Complex (WRC) - Homo sapiens [Reaction:R-HSA-2029469] p-ERK phosphorylates WAVEs and ABI - Homo sapiens [Reaction:R-HSA-2130194] ABL phosphorylates WAVEs - Homo sapiens [BlackBoxEvent:R-HSA-2029445] An unknown GEF exchanges GTP for GDP on CDC42:GDP - Homo sapiens [Reaction:R-HSA-9670156] PtdIns(4,5)P2 binds WASP, N-WASP - Homo sapiens [Reaction:R-HSA-9670155] CDC42:GTP binds PtdIns(4,5)P2:WASP,N-WASP - Homo sapiens [Reaction:R-HSA-442586] Activation of WASP and N-WASP by CDC42 - Homo sapiens [Reaction:R-HSA-2197691] WIP binds WASP,N-WASP, activating them - Homo sapiens [Reaction:R-HSA-2197698] Src phosphorylate WASP,N-WASP - Homo sapiens [Reaction:R-HSA-442592] WASPs or WAVEs activate the ARP2/3 complex - Homo sapiens [Reaction:R-HSA-2029466] (WASPs, WAVE):G-actin:ARP2/3 binds F-actin - Homo sapiens [Reaction:R-HSA-2197690] Detachment of WASP/WAVE - Homo sapiens [BlackBoxEvent:R-HSA-2029473] Branching and elongation of mother and daughter filaments - Homo sapiens [Reaction:R-HSA-1861595] Extension of pseudopodia by myosin-X in a PI3K dependent manner - Homo sapiens [BlackBoxEvent:R-HSA-9666458] IgG:Leishmania surface:FCGR3A translocates from plasma membrane to the parasitophorous vacuole - Homo sapiens
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:9664402] The roles of complement receptor 3 and Fc? receptors during Leishmania phagosome maturation [LiteratureReference:9664375] Receptor-mediated phagocytosis of Leishmania: implications for intracellular survival
maxDepth	2
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	FCGR3A-mediated phagocytosis
relatedSpecies	[Species:9658193] Leishmania major [Species:9666429] Leishmania mexicana
releaseDate	2020-03-17
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9675734] Gregory, David J, 2020-02-04
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-9664422
summation	[Summation:9664435] The Fc gamma receptors (FCGRs) have been reported to facilit...

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(hasEvent)

[Pathway:R-HSA-9664417] Leishmania phagocytosis

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