Reactome | IgG binds LPG1G2 in the amastigote form of Leishmania

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IgG binds LPG1G2 in the amastigote form of Leishmania Show undefined attributes

authored	[InstanceEdit:9664405] Murillo, Julieth, 2019-10-22
category	binding
compartment	[Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:9664405] Murillo, Julieth, 2019-10-22
crossReference	[DatabaseIdentifier:12020756] Mondo:0005446
dbId	9664397
disease	[Disease:9674660] cutaneous leishmaniasis
displayName	IgG binds LPG1G2 in the amastigote form of Leishmania
edited	[InstanceEdit:9675774] Murillo, Julieth, 2020-02-05 [InstanceEdit:9675991] Jassal, Bijay, 2020-02-05
eventOf	[Pathway:R-HSA-9664323] FCGR3A-mediated IL10 synthesis - Homo sapiens [Pathway:R-HSA-9664422] FCGR3A-mediated phagocytosis - Homo sapiens
followingEvent	[Reaction:R-HSA-9664406] IgG:Lma antigens binds FCGR3A:CD3 dimers - Homo sapiens [Reaction:R-HSA-9664268] Opsonized leishmania amastigote binds FCGR3 - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:23548] opsonization
inferredFrom	[Reaction:R-MMU-9670578] Mouse IgG binds LPG1G2 in the amastigote form of Leishmania - Mus musculus
input	[Complex:R-HSA-182629] IgG [extracellular region] [EntityWithAccessionedSequence:R-LMA-9664404] LPG1G2 [plasma membrane]
isChimeric	false
isInDisease	true
isInferred	true
literatureReference	[LiteratureReference:9664431] Opsonization modulates Rac-1 activation during cell entry by Leishmania amazonensis [LiteratureReference:9664373] Control of infection with Leishmania major in susceptible BALB/c mice lacking the common gamma-chain for FcR is associated with reduced production of IL-10 and TGF-beta by parasitized cells [LiteratureReference:9664276] Leishmania mexicana infection induces IgG to parasite surface glycoinositol phospholipids that can induce IL-10 in mice and humans
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	IgG binds LPG1G2 in the amastigote form of Leishmania
output	[Complex:R-HSA-9675736] IgG:LPG1G2 [plasma membrane]
relatedSpecies	[Species:9658193] Leishmania major
releaseDate	2020-03-17
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9675734] Gregory, David J, 2020-02-04
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9664397
summation	[Summation:9664412] The internalization of Leishmania amastigotes by macrophages...

Referrals

(hasEvent)	[Pathway:R-HSA-9664422] FCGR3A-mediated phagocytosis [Pathway:R-HSA-9664323] FCGR3A-mediated IL10 synthesis
(precedingEvent)	[Reaction:R-HSA-9664406] IgG:Lma antigens binds FCGR3A:CD3 dimers [Reaction:R-HSA-9664268] Opsonized leishmania amastigote binds FCGR3
(inferredTo)	[Reaction:R-MMU-9670578] Mouse IgG binds LPG1G2 in the amastigote form of Leishmania

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