Reactome | ABL phosphorylates WAVEs

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ABL phosphorylates WAVEs Show undefined attributes

authored	[InstanceEdit:434636] Jupe, S, 2009-09-02
catalystActivity	[CatalystActivity:2130201] protein tyrosine kinase activity of ABL1 [cytosol]
catalystActivityReference	[CatalystActivityReference:9643307] protein tyrosine kinase activity of ABL1 [cytosol] Abelson-interactor-1 promotes WAVE2 membrane translocation and Abelson-mediated tyrosine phosphorylation required for WAVE2 activation
category	transition
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:2130168] Garapati, P V, 2012-02-21
dbId	2130194
displayName	ABL phosphorylates WAVEs
edited	[InstanceEdit:2029483] Garapati, P V, 2012-01-04 [InstanceEdit:5671747] Orlic-Milacic, Marija, 2015-02-02
eventOf	[Pathway:R-HSA-5663213] RHO GTPases Activate WASPs and WAVEs - Homo sapiens [Pathway:R-HSA-2029482] Regulation of actin dynamics for phagocytic cup formation - Homo sapiens [Pathway:R-HSA-9664422] FCGR3A-mediated phagocytosis - Homo sapiens
followingEvent	[Reaction:R-HSA-2029469] p-ERK phosphorylates WAVEs and ABI - Homo sapiens [Reaction:R-HSA-442592] WASPs or WAVEs activate the ARP2/3 complex - Homo sapiens
input	3 × [SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-HSA-2029147] WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:2028973] Abelson-interactor-1 promotes WAVE2 membrane translocation and Abelson-mediated tyrosine phosphorylation required for WAVE2 activation
modified	[InstanceEdit:10740525] Wright, Adam, 2024-03-08
name	ABL phosphorylates WAVEs
orthologousEvent	[Reaction:R-CEL-2130194] ABL phosphorylates WAVEs - Caenorhabditis elegans [Reaction:R-DME-2130194] ABL phosphorylates WAVEs - Drosophila melanogaster [Reaction:R-GGA-2130194] ABL phosphorylates WAVEs - Gallus gallus [Reaction:R-XTR-2130194] ABL phosphorylates WAVEs - Xenopus tropicalis [Reaction:R-SSC-2130194] ABL phosphorylates WAVEs - Sus scrofa [Reaction:R-BTA-2130194] ABL phosphorylates WAVEs - Bos taurus [Reaction:R-CFA-2130194] ABL phosphorylates WAVEs - Canis familiaris [Reaction:R-RNO-2130194] ABL phosphorylates WAVEs - Rattus norvegicus [Reaction:R-MMU-2130194] ABL phosphorylates WAVEs - Mus musculus
output	3 × [SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-HSA-2130182] p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane]
precedingEvent	[Reaction:R-HSA-2029465] RAC1:GTP and PIP3 bind WAVE Regulatory Complex (WRC) - Homo sapiens
releaseDate	2013-03-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2248842] Rosales, C, 2012-05-14 [InstanceEdit:5668821] Rivero Crespo, Francisco, 2014-12-26
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-2130194
summation	[Summation:2130171] Abelson interactor-1 (ABL) tyrosine kinase phosphorylates th...

Referrals

(hasEvent)	[Pathway:R-HSA-9664422] FCGR3A-mediated phagocytosis [Pathway:R-HSA-5663213] RHO GTPases Activate WASPs and WAVEs [Pathway:R-HSA-2029482] Regulation of actin dynamics for phagocytic cup formation
(precedingEvent)	[Reaction:R-HSA-442592] WASPs or WAVEs activate the ARP2/3 complex [Reaction:R-HSA-2029469] p-ERK phosphorylates WAVEs and ABI

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