Reactome | PI(3,4,5)P3 binds VAV1,2,3

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PI(3,4,5)P3 binds VAV1,2,3 Show undefined attributes

authored	[InstanceEdit:434636] Jupe, S, 2009-09-02
category	binding
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:434636] Jupe, S, 2009-09-02
dbId	434637
displayName	PI(3,4,5)P3 binds VAV1,2,3
edited	[InstanceEdit:445674] Jupe, S, 2009-11-03
eventOf	[Pathway:R-HSA-9664422] FCGR3A-mediated phagocytosis - Homo sapiens [Pathway:R-HSA-114604] GPVI-mediated activation cascade - Homo sapiens [Pathway:R-HSA-4420097] VEGFA-VEGFR2 Pathway - Homo sapiens
followingEvent	[Reaction:R-HSA-5218820] Src kinases phosphorylate VAV - Homo sapiens [Reaction:R-HSA-442273] VAV1 is a GEF for Rho/Rac family GTPases - Homo sapiens [Reaction:R-HSA-9666435] VAV1,2,3:PI(3,4,5)P3 binds p-6Y-SYK - Homo sapiens
inferredFrom	[Reaction:R-MMU-434629] PIP3 stimulates Vav1 - Mus musculus
input	[SimpleEntity:R-ALL-179838] PI(3,4,5)P3 [plasma membrane] [DefinedSet:R-HSA-430172] VAV1,2,3 [cytosol]
isInDisease	false
isInferred	true
literatureReference	[LiteratureReference:389304] Role of substrates and products of PI 3-kinase in regulating activation of Rac-related guanosine triphosphatases by Vav
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	PI(3,4,5)P3 binds VAV1,2,3
output	[Complex:R-HSA-5340329] PIP3:VAV1,2,3 [plasma membrane]
precedingEvent	[Reaction:R-HSA-437162] PI3K alpha, beta, gamma convert PIP2 to PIP3 - Homo sapiens [Reaction:R-HSA-437936] p-Y348-SYK phosphorylates VAV family - Homo sapiens [Reaction:R-HSA-5218819] VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3 - Homo sapiens
releaseDate	2009-12-15
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:445650] Poole, AW, 2009-11-02 [InstanceEdit:445653] Jones, ML, 2009-11-02 [InstanceEdit:445649] Harper, MT, 2009-11-02
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-434637
summation	[Summation:434631] Vav interacts directly with PIP2 and PIP3, with a fivefold s...

Referrals

(precedingEvent)	[Reaction:R-HSA-442273] VAV1 is a GEF for Rho/Rac family GTPases [Reaction:R-HSA-9666435] VAV1,2,3:PI(3,4,5)P3 binds p-6Y-SYK [Reaction:R-HSA-5218820] Src kinases phosphorylate VAV
(hasEvent)	[Pathway:R-HSA-114604] GPVI-mediated activation cascade [Pathway:R-HSA-9664422] FCGR3A-mediated phagocytosis [Pathway:R-HSA-4420097] VEGFA-VEGFR2 Pathway
(inferredTo)	[Reaction:R-MMU-434629] PIP3 stimulates Vav1