Reactome | Leishmania major

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Leishmania major Show undefined attributes

abbreviation	LMA
created	[InstanceEdit:9658192] Murillo, Julieth, 2019-08-12
crossReference	[DatabaseIdentifier:9658194] NCBI Taxonomy:5664
dbId	9658193
displayName	Leishmania major
modified	[InstanceEdit:9667537] D'Eustachio, Peter, 2019-11-13
name	Leishmania major
schemaClass	Species
superTaxon	[Taxon:9667536] Leishmania major species complex
taxId	5664

Referrals

(relatedSpecies)

[Pathway:R-HSA-9658195] Leishmania infection
[Pathway:R-HSA-9664407] Parasite infection
[Pathway:R-HSA-9664417] Leishmania phagocytosis
[Pathway:R-HSA-9664422] FCGR3A-mediated phagocytosis
[BlackBoxEvent:R-HSA-9666458] IgG:Leishmania surface:FCGR3A translocates from plasma membrane to the parasitophorous vacuole
[Complex:R-HSA-9666434] IgG:Leishmania surface:FCGR3A [phagocytic cup]
[Reaction:R-HSA-9664406] IgG:Lma antigens binds FCGR3A:CD3 dimers
[BlackBoxEvent:R-HSA-9666433] IgG binds the surface of the amastigote form of Leishmania
[Pathway:R-HSA-9664433] Leishmania parasite growth and survival
[Pathway:R-HSA-9662851] Anti-inflammatory response favouring Leishmania parasite infection
[Pathway:R-HSA-9664323] FCGR3A-mediated IL10 synthesis
[Reaction:R-HSA-9666428] DOCK180 exchanges GTP for GDP on RAC1:GDP
[Reaction:R-HSA-9666426] CRKII:DOCK180:ELMO binds FCGR3A
[Complex:R-HSA-9666431] IgG:Leishmania surface:p-FCGR3A:p-6Y-SYK:CRKII:DOCK180:ELMO [plasma membrane]
[Reaction:R-HSA-9666430] p-VAV1,2,3 exchanges GTP for GDP on RAC1:GDP
[Reaction:R-HSA-9666425] p-6Y-SYK phosphorylates VAV1,2,3
[Reaction:R-HSA-9666435] VAV1,2,3:PI(3,4,5)P3 binds p-6Y-SYK
[Complex:R-HSA-9666421] IgG:Leishmania surface:FCGR3Ap-CD3 dimers:p-6Y-SYK:VAV1,2,3:PI(3,4,5)P3 [plasma membrane]
[Complex:R-HSA-9666423] IgG:Leishmania surface:p-FCGR3A:p-6Y-SYK:p-VAV1,2,3:PI(3,4,5)P3 [plasma membrane]
[Reaction:R-HSA-9664271] Release of PLCG from FCGR3A
[Reaction:R-HSA-9664278] Phosphorylation and activation of PLCG due to FCGR3A effect
[Reaction:R-HSA-9664270] Recruitment of PLCgamma to membrane due to FCGR3A effect
[Reaction:R-HSA-9664261] Src phosphorylate SYK in IgG:Leishmania surface:p-FCGR3A:SYK
[Reaction:R-HSA-9664273] SYK binds IgG:Lma antigens:FCGR3A:p-CD3 dimers
[Reaction:R-HSA-9664275] Src phosphorylates CD3 dimers in IgG:Lma antigens:FCGR3A:CD3 dimers
[Reaction:R-HSA-9664268] Opsonized leishmania amastigote binds FCGR3
[Reaction:R-HSA-9664397] IgG binds LPG1G2 in the amastigote form of Leishmania
[Reaction:R-MMU-9670578] Mouse IgG binds LPG1G2 in the amastigote form of Leishmania
[Complex:R-MMU-9664538] IgG:LPG1G2 [plasma membrane]
[Reaction:R-HSA-9664285] IgG binds the surface of the amastigote form of Leishmania
[Complex:R-HSA-9664263] IgG:Lma antigens:FCGR3A:CD3 dimers [plasma membrane]
[Complex:R-HSA-9664272] IgG:Lma antigens:FCGR3A:p-CD3 dimers:SYK [plasma membrane]
[Complex:R-HSA-9664266] IgG:Leishmania surface:p-FCGR3As:p-6Y-SYK:PLCG [plasma membrane]
[Complex:R-HSA-9664277] IgG:Leishmania surface:p-FCGR3A:p-6Y-SYK:p-3Y-PLCG [plasma membrane]
[Complex:R-HSA-9664265] IgG:Lma antigens:FCGR3A:p-CD3 dimers:p-6Y-SYK [plasma membrane]
[Complex:R-HSA-9664282] IgG:Lma antigens:FCGR3A:p-CD3 dimers [plasma membrane]
[DefinedSet:R-HSA-9666422] IgG:Lma antigens [plasma membrane]
[Complex:R-HSA-9675736] IgG:LPG1G2 [plasma membrane]
[Complex:R-HSA-9664283] IgG:Lma amastigote surface [plasma membrane]

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