Reactome | Src phosphorylate WASP,N-WASP

Schema > Reaction > Entries

Src phosphorylate WASP,N-WASP Show undefined attributes

authored	[InstanceEdit:434636] Jupe, S, 2009-09-02
catalystActivity	[CatalystActivity:2197705] protein tyrosine kinase activity of Src-kinases [cytosol]
catalystActivityReference	[CatalystActivityReference:9643128] protein tyrosine kinase activity of Src-kinases [cytosol] Focal adhesion kinase regulation of N-WASP subcellular localization and function
category	transition
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:2197699] Garapati, P V, 2012-04-13
dbId	2197698
displayName	Src phosphorylate WASP,N-WASP
edited	[InstanceEdit:2029483] Garapati, P V, 2012-01-04 [InstanceEdit:5671747] Orlic-Milacic, Marija, 2015-02-02
eventOf	[Pathway:R-HSA-5663213] RHO GTPases Activate WASPs and WAVEs - Homo sapiens [Pathway:R-HSA-2029482] Regulation of actin dynamics for phagocytic cup formation - Homo sapiens [Pathway:R-HSA-9664422] FCGR3A-mediated phagocytosis - Homo sapiens
followingEvent	[Reaction:R-HSA-442592] WASPs or WAVEs activate the ARP2/3 complex - Homo sapiens
input	2 × [SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-HSA-2197683] CDC42:GTP:WASP/N-WASP:WIP:SH3 proteins [plasma membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:2197710] Phosphorylation of tyrosine 291 enhances the ability of WASp to stimulate actin polymerization and filopodium formation. Wiskott-Aldrich Syndrome protein [LiteratureReference:2197695] Focal adhesion kinase regulation of N-WASP subcellular localization and function
modified	[InstanceEdit:10740525] Wright, Adam, 2024-03-08
name	Src phosphorylate WASP,N-WASP
orthologousEvent	[Reaction:R-CEL-2197698] Src phosphorylate WASP,N-WASP - Caenorhabditis elegans [Reaction:R-GGA-2197698] Src phosphorylate WASP,N-WASP - Gallus gallus [Reaction:R-BTA-2197698] Src phosphorylate WASP,N-WASP - Bos taurus [Reaction:R-CFA-2197698] Src phosphorylate WASP,N-WASP - Canis familiaris [Reaction:R-RNO-2197698] Src phosphorylate WASP,N-WASP - Rattus norvegicus [Reaction:R-MMU-2197698] Src phosphorylate WASP,N-WASP - Mus musculus
output	2 × [SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-HSA-2197680] CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane]
precedingEvent	[Reaction:R-HSA-2197691] WIP binds WASP,N-WASP, activating them - Homo sapiens
releaseDate	2013-03-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2248842] Rosales, C, 2012-05-14 [InstanceEdit:5668821] Rivero Crespo, Francisco, 2014-12-26
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-2197698
summation	[Summation:2197713] WASP is phosphorylated on Tyr291 (Cory et al. 2002) and N-WA...

Referrals

(hasEvent)	[Pathway:R-HSA-9664422] FCGR3A-mediated phagocytosis [Pathway:R-HSA-5663213] RHO GTPases Activate WASPs and WAVEs [Pathway:R-HSA-2029482] Regulation of actin dynamics for phagocytic cup formation
(precedingEvent)	[Reaction:R-HSA-442592] WASPs or WAVEs activate the ARP2/3 complex