Reactome | CDC42:GTP binds PtdIns(4,5)P2:WASP,N-WASP

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CDC42:GTP binds PtdIns(4,5)P2:WASP,N-WASP Show undefined attributes

authored	[InstanceEdit:9670158] Murillo, Julieth, 2019-12-05
category	binding
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:9670158] Murillo, Julieth, 2019-12-05
dbId	9670155
displayName	CDC42:GTP binds PtdIns(4,5)P2:WASP,N-WASP
edited	[InstanceEdit:9675774] Murillo, Julieth, 2020-02-05
eventOf	[Pathway:R-HSA-9664422] FCGR3A-mediated phagocytosis - Homo sapiens
followingEvent	[Reaction:R-HSA-2197691] WIP binds WASP,N-WASP, activating them - Homo sapiens
inferredFrom	[Reaction:R-MMU-442572] Activation of WASP and N-WASP by CDC42 - Mus musculus
input	[Complex:R-HSA-182921] CDC42:GTP [plasma membrane] [Complex:R-HSA-9667225] PI(4,5)P2:WASP/N-WASP [plasma membrane]
isChimeric	false
isInDisease	false
isInferred	true
literatureReference	[LiteratureReference:442552] The interaction between N-WASP and the Arp2/3 complex links Cdc42-dependent signals to actin assembly [LiteratureReference:2028916] EVH1/WH1 domains of VASP and WASP proteins belong to a large family including Ran-binding domains of the RanBP1 family [LiteratureReference:372997] Regulation of WASP/WAVE proteins: making a long story short [LiteratureReference:2028918] Autoinhibition and activation mechanisms of the Wiskott-Aldrich syndrome protein [LiteratureReference:2028921] Cdc42 regulates Fc gamma receptor-mediated phagocytosis through the activation and phosphorylation of Wiskott-Aldrich syndrome protein (WASP) and neural-WASP [LiteratureReference:2028917] Activation by Cdc42 and PIP(2) of Wiskott-Aldrich syndrome protein (WASp) stimulates actin nucleation by Arp2/3 complex
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	CDC42:GTP binds PtdIns(4,5)P2:WASP,N-WASP
output	[Complex:R-HSA-442584] CDC42:GTP:WASP/N-WASP [plasma membrane]
precedingEvent	[Reaction:R-HSA-9670156] PtdIns(4,5)P2 binds WASP, N-WASP - Homo sapiens
releaseDate	2020-03-17
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9675734] Gregory, David J, 2020-02-04
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9670155
summation	[Summation:442581] Wiskott-Aldrich syndrome protein (WASP) and Neural-WASP (N-W...

Referrals

(hasEvent)	[Pathway:R-HSA-9664422] FCGR3A-mediated phagocytosis
(precedingEvent)	[Reaction:R-HSA-2197691] WIP binds WASP,N-WASP, activating them
(inferredTo)	[Reaction:R-MMU-442572] Activation of WASP and N-WASP by CDC42