Reactome | p-6Y-SYK phosphorylates VAV1,2,3

Schema > Reaction > Entries

p-6Y-SYK phosphorylates VAV1,2,3 Show undefined attributes

authored	[InstanceEdit:9666432] Murillo, Julieth, 2019-11-05
catalystActivity	[CatalystActivity:9666695] protein tyrosine kinase activity of IgG:Lma antigens:FCGR3A:p-CD3 dimers:p-6Y-SYK [plasma membrane]
category	transition
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol [Compartment:984] extracellular region
created	[InstanceEdit:9666432] Murillo, Julieth, 2019-11-05
crossReference	[DatabaseIdentifier:12020756] Mondo:0005446
dbId	9666425
disease	[Disease:9674660] cutaneous leishmaniasis
displayName	p-6Y-SYK phosphorylates VAV1,2,3
edited	[InstanceEdit:9675774] Murillo, Julieth, 2020-02-05
eventOf	[Pathway:R-HSA-9664422] FCGR3A-mediated phagocytosis - Homo sapiens
followingEvent	[Reaction:R-HSA-9666430] p-VAV1,2,3 exchanges GTP for GDP on RAC1:GDP - Homo sapiens [Reaction:R-HSA-2029451] Activation of RAC1 by VAV - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-HSA-9666421] IgG:Leishmania surface:FCGR3Ap-CD3 dimers:p-6Y-SYK:VAV1,2,3:PI(3,4,5)P3 [plasma membrane]
isChimeric	false
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:2028947] Vav in natural killer cells is tyrosine phosphorylated upon cross-linking of Fc gamma RIIIA and is constitutively associated with a serine/threonine kinase
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	p-6Y-SYK phosphorylates VAV1,2,3
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-HSA-9666423] IgG:Leishmania surface:p-FCGR3A:p-6Y-SYK:p-VAV1,2,3:PI(3,4,5)P3 [plasma membrane]
precedingEvent	[Reaction:R-HSA-9666435] VAV1,2,3:PI(3,4,5)P3 binds p-6Y-SYK - Homo sapiens
relatedSpecies	[Species:9658193] Leishmania major
releaseDate	2020-03-17
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9675734] Gregory, David J, 2020-02-04
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9666425
summation	[Summation:2028828] VAV proteins exist in an auto-inhibitory state folded in suc...

Referrals

(hasEvent)	[Pathway:R-HSA-9664422] FCGR3A-mediated phagocytosis
(precedingEvent)	[Reaction:R-HSA-2029451] Activation of RAC1 by VAV [Reaction:R-HSA-9666430] p-VAV1,2,3 exchanges GTP for GDP on RAC1:GDP

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