Reactome | An unknown GEF exchanges GTP for GDP on CDC42:GDP

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An unknown GEF exchanges GTP for GDP on CDC42:GDP Show undefined attributes

authored	[InstanceEdit:434636] Jupe, S, 2009-09-02
catalystActivity	[CatalystActivity:2029264] guanyl-nucleotide exchange factor activity of Unknown GEF [cytosol]
category	uncertain
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:2029446] Garapati, P V, 2012-01-04
dbId	2029445
displayName	An unknown GEF exchanges GTP for GDP on CDC42:GDP
edited	[InstanceEdit:2029483] Garapati, P V, 2012-01-04
eventOf	[Pathway:R-HSA-2029482] Regulation of actin dynamics for phagocytic cup formation - Homo sapiens [Pathway:R-HSA-9664422] FCGR3A-mediated phagocytosis - Homo sapiens
followingEvent	[Reaction:R-HSA-2029456] RAC1 and CDC42 activate PAK1 - Homo sapiens [Reaction:R-HSA-442586] Activation of WASP and N-WASP by CDC42 - Homo sapiens [Reaction:R-HSA-9670156] PtdIns(4,5)P2 binds WASP, N-WASP - Homo sapiens
input	[Complex:R-HSA-418830] CDC42:GDP [cytosol] [SimpleEntity:R-ALL-29438] GTP [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:2028873] A Cdc42 activation cycle coordinated by PI 3-kinase during Fc receptor-mediated phagocytosis [LiteratureReference:2028975] Fc receptor-mediated phagocytosis requires CDC42 and Rac1
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	An unknown GEF exchanges GTP for GDP on CDC42:GDP
output	[Complex:R-HSA-182921] CDC42:GTP [plasma membrane] [SimpleEntity:R-ALL-29420] GDP [cytosol]
releaseDate	2013-03-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2248842] Rosales, C, 2012-05-14
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-2029445
summation	[Summation:2028900] FCGR mediated phagocytosis requires CDC42 to stimulate actin...

Referrals

(hasEvent)	[Pathway:R-HSA-9664422] FCGR3A-mediated phagocytosis [Pathway:R-HSA-2029482] Regulation of actin dynamics for phagocytic cup formation
(precedingEvent)	[Reaction:R-HSA-2029456] RAC1 and CDC42 activate PAK1 [Reaction:R-HSA-442586] Activation of WASP and N-WASP by CDC42 [Reaction:R-HSA-9670156] PtdIns(4,5)P2 binds WASP, N-WASP

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