Reactome | CRKII:DOCK180:ELMO binds FCGR3A

Schema > Reaction > Entries

CRKII:DOCK180:ELMO binds FCGR3A Show undefined attributes

authored	[InstanceEdit:9666432] Murillo, Julieth, 2019-11-05
category	binding
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol [Compartment:984] extracellular region
created	[InstanceEdit:9666432] Murillo, Julieth, 2019-11-05
crossReference	[DatabaseIdentifier:12020756] Mondo:0005446
dbId	9666426
disease	[Disease:9674660] cutaneous leishmaniasis
displayName	CRKII:DOCK180:ELMO binds FCGR3A
edited	[InstanceEdit:9675774] Murillo, Julieth, 2020-02-05
eventOf	[Pathway:R-HSA-9664422] FCGR3A-mediated phagocytosis - Homo sapiens
followingEvent	[Reaction:R-HSA-9666428] DOCK180 exchanges GTP for GDP on RAC1:GDP - Homo sapiens
input	[Complex:R-HSA-2029141] CRK:DOCK180:ELMO1,ELMO2 [cytosol] [Complex:R-HSA-9664265] IgG:Lma antigens:FCGR3A:p-CD3 dimers:p-6Y-SYK [plasma membrane]
isChimeric	false
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:2028903] Role of CrkII in Fcgamma receptor-mediated phagocytosis
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	CRKII:DOCK180:ELMO binds FCGR3A
output	[Complex:R-HSA-9666431] IgG:Leishmania surface:p-FCGR3A:p-6Y-SYK:CRKII:DOCK180:ELMO [plasma membrane]
precedingEvent	[Reaction:R-HSA-9664261] Src phosphorylate SYK in IgG:Leishmania surface:p-FCGR3A:SYK - Homo sapiens
relatedSpecies	[Species:9658193] Leishmania major
releaseDate	2020-03-17
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9675734] Gregory, David J, 2020-02-04
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9666426
summation	[Summation:2028779] Macrophages lacking all the three isoforms of VAV did not af...

Referrals

(hasEvent)	[Pathway:R-HSA-9664422] FCGR3A-mediated phagocytosis
(precedingEvent)	[Reaction:R-HSA-9666428] DOCK180 exchanges GTP for GDP on RAC1:GDP

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