Reactome | p-VAV1,2,3 exchanges GTP for GDP on RAC1:GDP

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p-VAV1,2,3 exchanges GTP for GDP on RAC1:GDP Show undefined attributes

authored	[InstanceEdit:9666432] Murillo, Julieth, 2019-11-05
catalystActivity	[CatalystActivity:9666424] guanyl-nucleotide exchange factor activity of IgG:Leishmania surface:p-FCGR3A:p-6Y-SYK:p-VAV1,2,3:PI(3,4,5)P3 [plasma membrane]
catalystActivityReference	[CatalystActivityReference:9643296] guanyl-nucleotide exchange factor activity of clustered IgG-Ag:p-FCGRs:p-6Y-SYK:p-VAV [plasma membrane] Phosphotyrosine-dependent activation of Rac-1 GDP/GTP exchange by the vav proto-oncogene product
category	transition
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:9666432] Murillo, Julieth, 2019-11-05
crossReference	[DatabaseIdentifier:12020756] Mondo:0005446
dbId	9666430
disease	[Disease:9674660] cutaneous leishmaniasis
displayName	p-VAV1,2,3 exchanges GTP for GDP on RAC1:GDP
edited	[InstanceEdit:9666432] Murillo, Julieth, 2019-11-05
eventOf	[Pathway:R-HSA-9664422] FCGR3A-mediated phagocytosis - Homo sapiens
followingEvent	[Reaction:R-HSA-2029465] RAC1:GTP and PIP3 bind WAVE Regulatory Complex (WRC) - Homo sapiens
input	[SimpleEntity:R-ALL-29438] GTP [cytosol] [Complex:R-HSA-5674631] RAC1:GDP [plasma membrane]
isChimeric	false
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:2028812] Requirements for Vav guanine nucleotide exchange factors and Rho GTPases in FcgammaR- and complement-mediated phagocytosis
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	p-VAV1,2,3 exchanges GTP for GDP on RAC1:GDP
output	[SimpleEntity:R-ALL-29420] GDP [cytosol] [Complex:R-HSA-442641] RAC1:GTP [plasma membrane]
precedingEvent	[Reaction:R-HSA-9666425] p-6Y-SYK phosphorylates VAV1,2,3 - Homo sapiens
relatedSpecies	[Species:9658193] Leishmania major
releaseDate	2020-03-17
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9675734] Gregory, David J, 2020-02-04
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9666430
summation	[Summation:2028888] The organized movements of membranes and the actin cytoskele...

Referrals

(hasEvent)	[Pathway:R-HSA-9664422] FCGR3A-mediated phagocytosis
(precedingEvent)	[Reaction:R-HSA-2029465] RAC1:GTP and PIP3 bind WAVE Regulatory Complex (WRC)

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