FCGR3A-mediated phagocytosis

Stable Identifier
R-HSA-9664422
Type
Pathway
Species
Homo sapiens
Related Species
Leishmania mexicana, Leishmania major
ReviewStatus
5/5
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FCGR3A-mediated phagocytosis
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The Fc gamma receptors (FCGRs) have been reported to facilitate Leishmania internalization, especially when in its amastigote form (Ueno et al. 2012). Following cell-to-cell propagation within an established infection or reinfection of a previously infected host, the IgG produced by the host covers the surface of Leishmania amastigote parasites, making them more susceptible to phagocytosis through FCGRs (Polando et al. 2013).

Classically, phagocytosis via FCGRs has been associated with the subsequent activation of Rac GTPases and Cdc42 which in turn activate the phagocyte's NADPH oxidase, contributing to the activation of killing mechanisms (Ueno et al. 2012).
Literature References
PubMed ID Title Journal Year
22726697 Receptor-mediated phagocytosis of Leishmania: implications for intracellular survival

Ueno, N, Wilson, ME

Trends Parasitol. 2012
23543768 The roles of complement receptor 3 and Fcγ receptors during Leishmania phagosome maturation

McDowell, MA, Ballhorn, W, Carter, CR, Wilson, ME, Jerde, CL, Harintho, M, Whitcomb, JP, Polando, R, Jones, B, Dixit, UG

J. Leukoc. Biol. 2013
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Event Information
Go Biological Process
Fc-gamma receptor signaling pathway involved in phagocytosis (0038096)
Disease
Name Identifier Synonyms
cutaneous leishmaniasis DOID:9111 Asian Desert Cutaneous Leishmaniasis, Leproid leishmaniasis, diffuse cutaneous leishmaniasis
Authored
Murillo, JI  (2020-01-07)
Jassal, B  (2020-01-07)
Reviewed
Gregory, DJ  (2020-02-04)
Created
Murillo, JI  (2019-10-22)
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