Reactome | Src phosphorylate SYK in IgG:Leishmania surface:p-FCGR3A:SYK

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Src phosphorylate SYK in IgG:Leishmania surface:p-FCGR3A:SYK Show undefined attributes

authored	[InstanceEdit:9664264] Murillo, Julieth, 2019-10-22
catalystActivity	[CatalystActivity:9666697] protein tyrosine kinase activity of Src family kinases (SFKs) [cytosol]
category	transition
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol [Compartment:984] extracellular region
created	[InstanceEdit:9664264] Murillo, Julieth, 2019-10-22
dbId	9664261
disease	[Disease:9674660] cutaneous leishmaniasis
displayName	Src phosphorylate SYK in IgG:Leishmania surface:p-FCGR3A:SYK
edited	[InstanceEdit:9675774] Murillo, Julieth, 2020-02-05
eventOf	[Pathway:R-HSA-9664422] FCGR3A-mediated phagocytosis - Homo sapiens [Pathway:R-HSA-9664323] FCGR3A-mediated IL10 synthesis - Homo sapiens
followingEvent	[Reaction:R-HSA-9666426] CRKII:DOCK180:ELMO binds FCGR3A - Homo sapiens [Reaction:R-HSA-9666435] VAV1,2,3:PI(3,4,5)P3 binds p-6Y-SYK - Homo sapiens [Reaction:R-HSA-9664270] Recruitment of PLCgamma to membrane due to FCGR3A effect - Homo sapiens [Reaction:R-HSA-2029458] Recruitment of VAV1 to p-6Y-SYK - Homo sapiens
input	6 × [SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-HSA-9664272] IgG:Lma antigens:FCGR3A:p-CD3 dimers:SYK [plasma membrane]
isChimeric	false
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:1861739] Phosphorylation of Tyr342 in the linker region of Syk is critical for Fc epsilon RI signaling in mast cells [LiteratureReference:1861548] Cbl-mediated negative regulation of the Syk tyrosine kinase. A critical role for Cbl phosphotyrosine-binding domain binding to Syk phosphotyrosine 323 [LiteratureReference:1861683] Identification of the major sites of autophosphorylation of the murine protein-tyrosine kinase Syk [LiteratureReference:1861676] syk kinase activation by a src kinase-initiated activation loop phosphorylation chain reaction [LiteratureReference:453188] Molecular mechanism of the Syk activation switch
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Src phosphorylate SYK in IgG:Leishmania surface:p-FCGR3A:SYK Phosphorylation of SYK attached to FCGR3A by Src kinases
output	6 × [SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-HSA-9664265] IgG:Lma antigens:FCGR3A:p-CD3 dimers:p-6Y-SYK [plasma membrane]
precedingEvent	[Reaction:R-HSA-9664273] SYK binds IgG:Lma antigens:FCGR3A:p-CD3 dimers - Homo sapiens
relatedSpecies	[Species:9658193] Leishmania major
releaseDate	2020-03-17
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9675734] Gregory, David J, 2020-02-04
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9664261
summation	[Summation:1861543] Multiple sites of phosphorylation are known to exist in SYK,...

Referrals

(hasEvent)	[Pathway:R-HSA-9664422] FCGR3A-mediated phagocytosis [Pathway:R-HSA-9664323] FCGR3A-mediated IL10 synthesis
(precedingEvent)	[Reaction:R-HSA-2029458] Recruitment of VAV1 to p-6Y-SYK [Reaction:R-HSA-9666426] CRKII:DOCK180:ELMO binds FCGR3A [Reaction:R-HSA-9666435] VAV1,2,3:PI(3,4,5)P3 binds p-6Y-SYK [Reaction:R-HSA-9664270] Recruitment of PLCgamma to membrane due to FCGR3A effect