Reactome | RAC1:GTP [plasma membrane]

Schema > Complex > Entries

RAC1:GTP [plasma membrane] Show undefined attributes

compartment	[Compartment:876] plasma membrane
componentOf	[Complex:R-HSA-9013182] RAC1:GTP:RAC1 effectors [plasma membrane] - Homo sapiens [Complex:R-HSA-5668712] NOX1 complex:RAC1:GTP [plasma membrane] - Homo sapiens [Complex:R-HSA-2029148] p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] - Homo sapiens [Complex:R-HSA-2685706] p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] - Homo sapiens
consumedByEvent	[BlackBoxEvent:R-HSA-9691168] RAC1 translocates to the endoplasmic reticulum membrane - Homo sapiens [Reaction:R-HSA-9013144] RAC1 GAPs stimulate RAC1 GTPase activity - Homo sapiens [Reaction:R-HSA-9013145] RAC1 binds effectors at the plasma membrane - Homo sapiens [Reaction:R-HSA-9673288] ppDVL binds RAC1:GTP - Homo sapiens [Reaction:R-HSA-445072] Interaction of PAK1 with Rac1-GTP - Homo sapiens [Reaction:R-HSA-428522] Inactivation of RAC1 - Homo sapiens [Reaction:R-HSA-5663232] FMNL1 binds RAC1:GTP - Homo sapiens [Reaction:R-HSA-5668714] RAC1:GTP binds NOX1 complex - Homo sapiens [Reaction:R-HSA-5668735] RAC1:GTP binds NOX3 complex - Homo sapiens [Reaction:R-HSA-399941] Rac1 binds PlexinA - Homo sapiens [Reaction:R-HSA-400682] Active Rac1 interacts with Plexin-B1:Sema4D - Homo sapiens [Reaction:R-HSA-5218827] NADPH oxidase 2 (NOX2) complex binds RAC1 - Homo sapiens [Reaction:R-HSA-2029465] RAC1:GTP and PIP3 bind WAVE Regulatory Complex (WRC) - Homo sapiens
created	[InstanceEdit:442639] Jupe, S, 2009-09-29
dbId	442641
deleted	[Deleted:9020700] Deletion of instance: 372685
displayName	RAC1:GTP [plasma membrane]
hasComponent	[SimpleEntity:R-ALL-29438] GTP [cytosol] [EntityWithAccessionedSequence:R-HSA-351141] RAC1 [plasma membrane]
inDisease	false
includedLocation	[Compartment:70101] cytosol
inferredTo	[Complex:R-MMU-2316458] Rac1:GTP [plasma membrane] - Mus musculus [Complex:R-RNO-9628560] Rac1:GTP [plasma membrane] - Rattus norvegicus [Complex:R-CFA-442641] RAC1:GTP [plasma membrane] - Canis familiaris [Complex:R-BTA-442641] RAC1:GTP [plasma membrane] - Bos taurus [Complex:R-SSC-442641] RAC1:GTP [plasma membrane] - Sus scrofa [Complex:R-DRE-442641] RAC1:GTP [plasma membrane] - Danio rerio [Complex:R-XTR-442641] RAC1:GTP [plasma membrane] - Xenopus tropicalis [Complex:R-GGA-442641] RAC1:GTP [plasma membrane] - Gallus gallus [Complex:R-DME-351067] RAC1:GTP [plasma membrane] - Drosophila melanogaster [Complex:R-CEL-442641] RAC1:GTP [plasma membrane] - Caenorhabditis elegans [Complex:R-DDI-442641] RAC1:GTP [plasma membrane] - Dictyostelium discoideum [Complex:R-SCE-442641] RAC1:GTP [plasma membrane] - Saccharomyces cerevisiae
isChimeric	false
maxDepth	2
memberOf	[DefinedSet:R-HSA-9615275] RAC1:GTP,RAC2:GTP,RHOG:GTP [plasma membrane] - Homo sapiens [DefinedSet:R-HSA-389778] CDC42:GTP, RAC1:GTP [plasma membrane] - Homo sapiens [DefinedSet:R-HSA-8981458] RHOA,RHOB,RHOC,RAC1:GTP [plasma membrane] - Homo sapiens
modified	[InstanceEdit:5634775] Orlic-Milacic, Marija, 2014-11-06
name	RAC1:GTP
producedByEvent	[Reaction:R-HSA-9013143] RAC1 GEFs activate RAC1 - Homo sapiens [Reaction:R-HSA-428535] Activation of RAC1 by SOS - Homo sapiens [BlackBoxEvent:R-HSA-8875591] DOCK7 activates RAC1 - Homo sapiens [Reaction:R-HSA-1433415] Activation of RAC1 - Homo sapiens [Reaction:R-HSA-9666430] p-VAV1,2,3 exchanges GTP for GDP on RAC1:GDP - Homo sapiens [Reaction:R-HSA-389348] Activation of Rac1 by pVav1 - Homo sapiens [Reaction:R-HSA-9619803] p-S516-ARHGEF7 activates RAC1 - Homo sapiens [Reaction:R-HSA-9033292] NTRK2 and CDK5 promote activation of RAC1 by TIAM1 - Homo sapiens [BlackBoxEvent:R-HSA-9032798] DOCK3 activates RAC1 - Homo sapiens [Reaction:R-HSA-4093336] p-TIAM1 exchanges GTP for GDP on RAC1, activating it - Homo sapiens [Reaction:R-HSA-3928628] VAV exchanges GTP for GDP on RAC1, activating it - Homo sapiens [Reaction:R-HSA-3928642] TIAM1 exchanges GTP for GDP on RAC1, activating it - Homo sapiens [Reaction:R-HSA-445064] Activation of Rac1 by VAV2 - Homo sapiens [Reaction:R-HSA-8848618] Activation of RAC1 by the PXN:CRK complex - Homo sapiens [Reaction:R-HSA-5218839] DOCK180:ELMO exchanges GTP for GDP, activating RAC1 - Homo sapiens [Reaction:R-HSA-9666428] DOCK180 exchanges GTP for GDP on RAC1:GDP - Homo sapiens [Reaction:R-HSA-2029451] Activation of RAC1 by VAV - Homo sapiens [Reaction:R-HSA-2029467] Activation of RAC1 by CRKII:DOCK180:ELMO - Homo sapiens [Reaction:R-HSA-399938] Activation of Rac1 by FARP2 - Homo sapiens [Reaction:R-HSA-2424476] Activation of RAC1 by VAV2/3 - Homo sapiens
schemaClass	Complex
species	[Species:48887] Homo sapiens
stId	R-HSA-442641

Referrals

(hasComponent)	[Complex:R-HSA-9013182] RAC1:GTP:RAC1 effectors [plasma membrane] [Complex:R-HSA-9675729] WNT5:FZD7:pp-DVL:RAC1:GTP [plasma membrane] [Complex:R-HSA-445001] pPAK1:Rac1-GTP [cytosol] [Complex:R-HSA-5668712] NOX1 complex:RAC1:GTP [plasma membrane] [Complex:R-HSA-5668738] NOX3 complex:RAC1:GTP [plasma membrane] [Complex:R-HSA-5218774] NOX2 complex:RAC1:GTP [plasma membrane] [Complex:R-HSA-2685706] p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] [Complex:R-HSA-2029148] p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] [Complex:R-HSA-2130182] p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] [Complex:R-HSA-2029147] WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] [Complex:R-HSA-5218784] p-VAV family:PIP3:RAC1:GTP [plasma membrane] [Complex:R-HSA-399872] Sema3A:Nrp-1:pPlexinA:Fyn:Fes:Rac-1-GTP [plasma membrane] [Complex:R-HSA-418826] NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO:RAC1:GTP [plasma membrane] [Complex:R-HSA-5663231] RAC1:GTP:FMNL1 [plasma membrane] [Complex:R-HSA-400679] Sema4D:pPlexin-B1:Met:RAC1-GTP [plasma membrane]
(input)	[BlackBoxEvent:R-HSA-9691168] RAC1 translocates to the endoplasmic reticulum membrane [Reaction:R-HSA-9013144] RAC1 GAPs stimulate RAC1 GTPase activity [Reaction:R-HSA-9013145] RAC1 binds effectors at the plasma membrane [Reaction:R-HSA-9673288] ppDVL binds RAC1:GTP [Reaction:R-HSA-445072] Interaction of PAK1 with Rac1-GTP [Reaction:R-HSA-428522] Inactivation of RAC1 [Reaction:R-HSA-5668714] RAC1:GTP binds NOX1 complex [Reaction:R-HSA-5668735] RAC1:GTP binds NOX3 complex [Reaction:R-HSA-2029465] RAC1:GTP and PIP3 bind WAVE Regulatory Complex (WRC) [Reaction:R-HSA-5663232] FMNL1 binds RAC1:GTP [Reaction:R-HSA-399941] Rac1 binds PlexinA [Reaction:R-HSA-400682] Active Rac1 interacts with Plexin-B1:Sema4D [Reaction:R-HSA-5218827] NADPH oxidase 2 (NOX2) complex binds RAC1
(output)	[Reaction:R-HSA-9013143] RAC1 GEFs activate RAC1 [Reaction:R-HSA-4093336] p-TIAM1 exchanges GTP for GDP on RAC1, activating it [Reaction:R-HSA-3928628] VAV exchanges GTP for GDP on RAC1, activating it [Reaction:R-HSA-3928642] TIAM1 exchanges GTP for GDP on RAC1, activating it [Reaction:R-HSA-445064] Activation of Rac1 by VAV2 [Reaction:R-HSA-428535] Activation of RAC1 by SOS [BlackBoxEvent:R-HSA-8875591] DOCK7 activates RAC1 [Reaction:R-HSA-1433415] Activation of RAC1 [Reaction:R-HSA-8848618] Activation of RAC1 by the PXN:CRK complex [Reaction:R-HSA-5218839] DOCK180:ELMO exchanges GTP for GDP, activating RAC1 [Reaction:R-HSA-9666430] p-VAV1,2,3 exchanges GTP for GDP on RAC1:GDP [Reaction:R-HSA-9666428] DOCK180 exchanges GTP for GDP on RAC1:GDP [Reaction:R-HSA-2029451] Activation of RAC1 by VAV [Reaction:R-HSA-2029467] Activation of RAC1 by CRKII:DOCK180:ELMO [Reaction:R-HSA-389348] Activation of Rac1 by pVav1 [Reaction:R-HSA-399938] Activation of Rac1 by FARP2 [Reaction:R-HSA-9619803] p-S516-ARHGEF7 activates RAC1 [Reaction:R-HSA-9033292] NTRK2 and CDK5 promote activation of RAC1 by TIAM1 [BlackBoxEvent:R-HSA-9032798] DOCK3 activates RAC1 [Reaction:R-HSA-2424476] Activation of RAC1 by VAV2/3
(hasMember)	[DefinedSet:R-HSA-9615275] RAC1:GTP,RAC2:GTP,RHOG:GTP [plasma membrane] [CandidateSet:R-HSA-9959034] RAC1:GTP,(CDC42:GTP) [plasma membrane] [DefinedSet:R-HSA-389778] CDC42:GTP, RAC1:GTP [plasma membrane] [DefinedSet:R-HSA-8981458] RHOA,RHOB,RHOC,RAC1:GTP [plasma membrane]
(activeUnit)	[CatalystActivity:5665807] GTPase activity of SRGAP2:RAC1:GTP:FMNL1:Profilin:G-actin [plasma membrane]
(replacementInstances)	[Deleted:9020700] Deletion of instance: 372685

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