Reactome | Activation of RAC1 by VAV2/3

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Activation of RAC1 by VAV2/3 Show undefined attributes

authored	[InstanceEdit:2272794] Garapati, P V, 2012-05-25
catalystActivity	[CatalystActivity:2424488] guanyl-nucleotide exchange factor activity of p-5Y-LAT:PLCG1:GADS:p-3Y-SLP-76:BTK:p-VAV [plasma membrane]
category	transition
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:2424489] Garapati, P V, 2012-07-23
dbId	2424476
displayName	Activation of RAC1 by VAV2/3
edited	[InstanceEdit:2272794] Garapati, P V, 2012-05-25
eventOf	[Pathway:R-HSA-2424491] DAP12 signaling - Homo sapiens
input	[SimpleEntity:R-ALL-29438] GTP [cytosol] [Complex:R-HSA-445010] RAC1:GDP [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:2424443] Vav2 is an activator of Cdc42, Rac1, and RhoA [LiteratureReference:2424427] Vav3 mediates receptor protein tyrosine kinase signaling, regulates GTPase activity, modulates cell morphology, and induces cell transformation
maxDepth	1
modified	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
name	Activation of RAC1 by VAV2/3
orthologousEvent	[Reaction:R-MMU-2424476] Activation of RAC1 by VAV2/3 - Mus musculus [Reaction:R-DME-2424476] Activation of RAC1 by VAV2/3 - Drosophila melanogaster [Reaction:R-GGA-2424476] Activation of RAC1 by VAV2/3 - Gallus gallus [Reaction:R-SSC-2424476] Activation of RAC1 by VAV2/3 - Sus scrofa [Reaction:R-CFA-2424476] Activation of RAC1 by VAV2/3 - Canis familiaris [Reaction:R-RNO-2424476] Activation of RAC1 by VAV2/3 - Rattus norvegicus
output	[SimpleEntity:R-ALL-29420] GDP [cytosol] [Complex:R-HSA-442641] RAC1:GTP [plasma membrane]
precedingEvent	[Reaction:R-HSA-2424486] Phosphorylation and activation of VAV2/VAV3 by SYK - Homo sapiens
releaseDate	2012-09-18
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2428957] Lanier, Lewis L, 2012-08-09
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-2424476
summation	[Summation:2424414] Activated VAV2/3 act as guanine nucleotide exchange factors ...

Referrals

(hasEvent)

[Pathway:R-HSA-2424491] DAP12 signaling

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