Reactome | Activation of RAC1 by SOS

Schema > Reaction > Entries

authored	[InstanceEdit:376175] Garapati, P V, 2008-09-05 06:02:05
catalystActivity	[CatalystActivity:428513] guanyl-nucleotide exchange factor activity of SLIT2:ROBO1:NCK:SOS [plasma membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:428526] Garapati, P V, 2009-07-06
dbId	428535
displayName	Activation of RAC1 by SOS
edited	[InstanceEdit:376175] Garapati, P V, 2008-09-05 06:02:05 [InstanceEdit:9010186] Orlic-Milacic, Marija, 2017-06-26
eventOf	[Pathway:R-HSA-428540] Activation of RAC1 - Homo sapiens
followingEvent	[Reaction:R-HSA-428522] Inactivation of RAC1 - Homo sapiens
inferredFrom	[Reaction:R-DME-428523] Activation of Rac by Sos - Drosophila melanogaster
input	[SimpleEntity:R-ALL-29438] GTP [cytosol] [Complex:R-HSA-5674631] RAC1:GDP [plasma membrane]
isInDisease	false
isInferred	true
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Activation of RAC1 by SOS
output	[SimpleEntity:R-ALL-29420] GDP [cytosol] [Complex:R-HSA-442641] RAC1:GTP [plasma membrane]
precedingEvent	[Reaction:R-HSA-428515] Recruitment of SOS to plasma membrane - Homo sapiens
releaseDate	2009-09-30
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:434966] Kidd, T, 2009-08-18 [InstanceEdit:9014887] Jaworski, Alexander, 2017-07-31
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-428535
summation	[Summation:428415] SOS (SOS1 or SOS2), bound to Dock orholog NCK (NCK1 or NCK2)...

(hasEvent)	[Pathway:R-HSA-428540] Activation of RAC1
(precedingEvent)	[Reaction:R-HSA-428522] Inactivation of RAC1
(inferredTo)	[Reaction:R-DME-428523] Activation of Rac by Sos

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