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Schema
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Reaction
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Entries
NADPH oxidase 2 (NOX2) complex binds RAC1
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authored
[InstanceEdit:4420157] Garapati, P V, 2013-08-30
category
binding
compartment
[Compartment:876] plasma membrane
created
[InstanceEdit:5218840] Garapati, P V, 2013-12-19
dbId
5218827
displayName
NADPH oxidase 2 (NOX2) complex binds RAC1
edited
[InstanceEdit:4420157] Garapati, P V, 2013-08-30
[InstanceEdit:5671747] Orlic-Milacic, Marija, 2015-02-02
[InstanceEdit:9861985] Orlic-Milacic, Marija, 2024-02-21
eventOf
[Pathway:R-HSA-5668599] RHO GTPases Activate NADPH Oxidases - Homo sapiens
[Pathway:R-HSA-4420097] VEGFA-VEGFR2 Pathway - Homo sapiens
followingEvent
[Reaction:R-HSA-5218841] NADPH oxidase 2 generates superoxide from oxygen - Homo sapiens
input
[Complex:R-HSA-5218791] NOX2 complex [plasma membrane]
[Complex:R-HSA-442641] RAC1:GTP [plasma membrane]
isChimeric
false
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:9861981] Rac activation induces NADPH oxidase activity in transgenic COSphox cells, and the level of superoxide production is exchange factor-dependent
maxDepth
1
modified
[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name
NADPH oxidase 2 (NOX2) complex binds RAC1
orthologousEvent
[Reaction:R-GGA-5218827] NADPH oxidase 2 (NOX2) complex binds RAC1 - Gallus gallus
[Reaction:R-DRE-5218827] NADPH oxidase 2 (NOX2) complex binds RAC1 - Danio rerio
[Reaction:R-SSC-5218827] NADPH oxidase 2 (NOX2) complex binds RAC1 - Sus scrofa
[Reaction:R-CFA-5218827] NADPH oxidase 2 (NOX2) complex binds RAC1 - Canis familiaris
[Reaction:R-RNO-5218827] NADPH oxidase 2 (NOX2) complex binds RAC1 - Rattus norvegicus
[Reaction:R-MMU-5218827] NADPH oxidase 2 (NOX2) complex binds RAC1 - Mus musculus
output
[Complex:R-HSA-5218774] NOX2 complex:RAC1:GTP [plasma membrane]
precedingEvent
[Reaction:R-HSA-5218850] VAV exchanges GTP for GDP on RAC1, activating it - Homo sapiens
[Reaction:R-HSA-5218839] DOCK180:ELMO exchanges GTP for GDP, activating RAC1 - Homo sapiens
releaseDate
2014-06-10
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:5432673] Welsh, Michael, Berger, Philipp, Ballmer-Hofer, Kurt, 2014-05-12
[InstanceEdit:5668821] Rivero Crespo, Francisco, 2014-12-26
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-5218827
summation
[Summation:5218490] Direct interaction between recombinant GTP-bound human RAC1 ...
updateTrackers
[UpdateTracker:9864146] Update Tracker - [Reaction:5218827] NADPH oxidase 2 (NOX2) complex binds RAC1 - v88:[add_removeLiteratureReference, modifyText]
[UpdateTracker:9785192] Update Tracker - [Reaction:5218827] NADPH oxidase 2 (NOX2) complex binds RAC1 - v52:[modifyText]
[UpdateTracker:9783153] Update Tracker - [Reaction:5218827] NADPH oxidase 2 (NOX2) complex binds RAC1 - v57:[add_removeInput]
Referrals
(updatedInstance)
[UpdateTracker:9864146] Update Tracker - [Reaction:5218827] NADPH oxidase 2 (NOX2) complex binds RAC1 - v88:[add_removeLiteratureReference, modifyText]
[UpdateTracker:9785192] Update Tracker - [Reaction:5218827] NADPH oxidase 2 (NOX2) complex binds RAC1 - v52:[modifyText]
[UpdateTracker:9783153] Update Tracker - [Reaction:5218827] NADPH oxidase 2 (NOX2) complex binds RAC1 - v57:[add_removeInput]
(hasEvent)
[Pathway:R-HSA-4420097] VEGFA-VEGFR2 Pathway
[Pathway:R-HSA-5668599] RHO GTPases Activate NADPH Oxidases
(precedingEvent)
[Reaction:R-HSA-5218841] NADPH oxidase 2 generates superoxide from oxygen
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