Reactome | DOCK7 activates RAC1

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DOCK7 activates RAC1 Show undefined attributes

authored	[InstanceEdit:8876386] Orlic-Milacic, Marija, 2016-06-14
catalystActivity	[CatalystActivity:8875590] guanyl-nucleotide exchange factor activity of HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL:(DOCK7) [plasma membrane]
category	uncertain
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:8875589] Orlic-Milacic, Marija, 2016-06-07
dbId	8875591
displayName	DOCK7 activates RAC1
edited	[InstanceEdit:8876386] Orlic-Milacic, Marija, 2016-06-14
eventOf	[Pathway:R-HSA-8875555] MET activates RAP1 and RAC1 - Homo sapiens
input	[SimpleEntity:R-ALL-29438] GTP [cytosol] [Complex:R-HSA-5674631] RAC1:GDP [plasma membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:8875583] Guanine nucleotide exchange factor Dock7 mediates HGF-induced glioblastoma cell invasion via Rac activation
modified	[InstanceEdit:10740525] Wright, Adam, 2024-03-08
name	DOCK7 activates RAC1
orthologousEvent	[BlackBoxEvent:R-GGA-8875591] DOCK7 activates RAC1 - Gallus gallus [BlackBoxEvent:R-CEL-8875591] DOCK7 activates RAC1 - Caenorhabditis elegans [BlackBoxEvent:R-XTR-8875591] DOCK7 activates RAC1 - Xenopus tropicalis [BlackBoxEvent:R-SSC-8875591] DOCK7 activates RAC1 - Sus scrofa [BlackBoxEvent:R-BTA-8875591] DOCK7 activates RAC1 - Bos taurus [BlackBoxEvent:R-CFA-8875591] DOCK7 activates RAC1 - Canis familiaris [BlackBoxEvent:R-RNO-8875591] DOCK7 activates RAC1 - Rattus norvegicus [BlackBoxEvent:R-MMU-8875591] DOCK7 activates RAC1 - Mus musculus
output	[SimpleEntity:R-ALL-29420] GDP [cytosol] [Complex:R-HSA-442641] RAC1:GTP [plasma membrane]
precedingEvent	[BlackBoxEvent:R-HSA-8875576] CRK,CRKL recruits RAC1 GEF to activated MET - Homo sapiens
releaseDate	2016-09-19
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8931695] Heynen, Guustaaf, 2016-07-11 [InstanceEdit:8931697] Birchmeier, Walter, 2016-07-11
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-8875591
summation	[Summation:8875593] DOCK7, recruited to the activated MET receptor complex throu...

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(hasEvent)

[Pathway:R-HSA-8875555] MET activates RAP1 and RAC1