Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Contributors
Papers Citing Us
Resources Guide
Collaboration
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Contributors
Papers Citing Us
Resources Guide
Collaboration
Download
Search ...
Go!
Schema
>
Reaction
>
Entries
DOCK180:ELMO exchanges GTP for GDP, activating RAC1
Show undefined attributes
Go to Details
authored
[InstanceEdit:4420157] Garapati, P V, 2013-08-30
catalystActivity
[CatalystActivity:5218831] guanyl-nucleotide exchange factor activity of CRK:DOCK180:ELMO1,ELMO2:VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1,VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane]
catalystActivityReference
[CatalystActivityReference:9643413] guanyl-nucleotide exchange factor activity of CRK:DOCK180:ELMO1,ELMO2:VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1,VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] Unconventional Rac-GEF activity is mediated through the Dock180-ELMO complex
category
transition
compartment
[Compartment:876] plasma membrane
[Compartment:70101] cytosol
created
[InstanceEdit:5218840] Garapati, P V, 2013-12-19
dbId
5218839
displayName
DOCK180:ELMO exchanges GTP for GDP, activating RAC1
edited
[InstanceEdit:4420157] Garapati, P V, 2013-08-30
eventOf
[Pathway:R-HSA-4420097] VEGFA-VEGFR2 Pathway - Homo sapiens
followingEvent
[Reaction:R-HSA-2029465] RAC1:GTP and PIP3 bind WAVE Regulatory Complex (WRC) - Homo sapiens
input
[SimpleEntity:R-ALL-29438] GTP [cytosol]
[Complex:R-HSA-5674631] RAC1:GDP [plasma membrane]
isChimeric
false
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:372673] Unconventional Rac-GEF activity is mediated through the Dock180-ELMO complex
modified
[InstanceEdit:10655440] Wright, Adam, 2024-03-08
name
DOCK180:ELMO exchanges GTP for GDP, activating RAC1
orthologousEvent
[Reaction:R-DME-5218839] DOCK180:ELMO exchanges GTP for GDP, activating RAC1 - Drosophila melanogaster
[Reaction:R-GGA-5218839] DOCK180:ELMO exchanges GTP for GDP, activating RAC1 - Gallus gallus
[Reaction:R-XTR-5218839] DOCK180:ELMO exchanges GTP for GDP, activating RAC1 - Xenopus tropicalis
[Reaction:R-SSC-5218839] DOCK180:ELMO exchanges GTP for GDP, activating RAC1 - Sus scrofa
[Reaction:R-BTA-5218839] DOCK180:ELMO exchanges GTP for GDP, activating RAC1 - Bos taurus
[Reaction:R-CFA-5218839] DOCK180:ELMO exchanges GTP for GDP, activating RAC1 - Canis familiaris
[Reaction:R-RNO-5218839] DOCK180:ELMO exchanges GTP for GDP, activating RAC1 - Rattus norvegicus
[Reaction:R-MMU-5218839] DOCK180:ELMO exchanges GTP for GDP, activating RAC1 - Mus musculus
output
[SimpleEntity:R-ALL-29420] GDP [cytosol]
[Complex:R-HSA-442641] RAC1:GTP [plasma membrane]
precedingEvent
[Reaction:R-HSA-5218811] DOCK180:ELMO binds CRK - Homo sapiens
releaseDate
2014-06-10
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:5432673] Welsh, Michael, Berger, Philipp, Ballmer-Hofer, Kurt, 2014-05-12
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-5218839
summation
[Summation:5218492] RAC1 is activated from inactive GDP-bound state to active GT...
Referrals
(hasEvent)
[Pathway:R-HSA-4420097] VEGFA-VEGFR2 Pathway
(precedingEvent)
[Reaction:R-HSA-2029465] RAC1:GTP and PIP3 bind WAVE Regulatory Complex (WRC)
© 2024
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text