Reactome | DOCK180:ELMO exchanges GTP for GDP, activating RAC1

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DOCK180:ELMO exchanges GTP for GDP, activating RAC1 Show undefined attributes

authored	[InstanceEdit:4420157] Garapati, P V, 2013-08-30
catalystActivity	[CatalystActivity:5218831] guanyl-nucleotide exchange factor activity of CRK:DOCK180:ELMO1,ELMO2:VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1,VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane]
catalystActivityReference	[CatalystActivityReference:9643413] guanyl-nucleotide exchange factor activity of CRK:DOCK180:ELMO1,ELMO2:VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1,VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] Unconventional Rac-GEF activity is mediated through the Dock180-ELMO complex
category	transition
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:5218840] Garapati, P V, 2013-12-19
dbId	5218839
displayName	DOCK180:ELMO exchanges GTP for GDP, activating RAC1
edited	[InstanceEdit:4420157] Garapati, P V, 2013-08-30
eventOf	[Pathway:R-HSA-4420097] VEGFA-VEGFR2 Pathway - Homo sapiens
followingEvent	[Reaction:R-HSA-2029465] RAC1:GTP and PIP3 bind WAVE Regulatory Complex (WRC) - Homo sapiens [Reaction:R-HSA-5218827] NADPH oxidase 2 (NOX2) complex binds RAC1 - Homo sapiens
input	[SimpleEntity:R-ALL-29438] GTP [cytosol] [Complex:R-HSA-5674631] RAC1:GDP [plasma membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:372673] Unconventional Rac-GEF activity is mediated through the Dock180-ELMO complex
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	DOCK180:ELMO exchanges GTP for GDP, activating RAC1
orthologousEvent	[Reaction:R-CEL-5218839] DOCK180:ELMO exchanges GTP for GDP, activating RAC1 - Caenorhabditis elegans [Reaction:R-GGA-5218839] DOCK180:ELMO exchanges GTP for GDP, activating RAC1 - Gallus gallus [Reaction:R-DRE-5218839] DOCK180:ELMO exchanges GTP for GDP, activating RAC1 - Danio rerio [Reaction:R-SSC-5218839] DOCK180:ELMO exchanges GTP for GDP, activating RAC1 - Sus scrofa [Reaction:R-CFA-5218839] DOCK180:ELMO exchanges GTP for GDP, activating RAC1 - Canis familiaris [Reaction:R-RNO-5218839] DOCK180:ELMO exchanges GTP for GDP, activating RAC1 - Rattus norvegicus [Reaction:R-MMU-5218839] DOCK180:ELMO exchanges GTP for GDP, activating RAC1 - Mus musculus
output	[SimpleEntity:R-ALL-29420] GDP [cytosol] [Complex:R-HSA-442641] RAC1:GTP [plasma membrane]
precedingEvent	[Reaction:R-HSA-5218811] DOCK180:ELMO binds CRK - Homo sapiens
releaseDate	2014-06-10
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5432673] Welsh, Michael, Berger, Philipp, Ballmer-Hofer, Kurt, 2014-05-12
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-5218839
summation	[Summation:5218492] RAC1 is activated from inactive GDP-bound state to active GT...
updateTrackers	[UpdateTracker:9783126] Update Tracker - [Reaction:5218839] DOCK180:ELMO exchanges GTP for GDP, activating RAC1 - v57:[add_removeInput, add_removeOutput]

Referrals

(updatedInstance)	[UpdateTracker:9783126] Update Tracker - [Reaction:5218839] DOCK180:ELMO exchanges GTP for GDP, activating RAC1 - v57:[add_removeInput, add_removeOutput]
(hasEvent)	[Pathway:R-HSA-4420097] VEGFA-VEGFR2 Pathway
(precedingEvent)	[Reaction:R-HSA-5218827] NADPH oxidase 2 (NOX2) complex binds RAC1 [Reaction:R-HSA-2029465] RAC1:GTP and PIP3 bind WAVE Regulatory Complex (WRC)