Reactome | DOCK3 activates RAC1

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DOCK3 activates RAC1 Show undefined attributes

authored	[InstanceEdit:9034391] Orlic-Milacic, Marija, 2018-01-05
catalystActivity	[CatalystActivity:9032805] guanyl-nucleotide exchange factor activity of BDNF:p-5Y-NTRK2 homodimer:MyrG,p-Y420-FYN-1:DOCK3 [plasma membrane]
category	uncertain
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:9032799] Orlic-Milacic, Marija, 2017-12-18
dbId	9032798
displayName	DOCK3 activates RAC1
edited	[InstanceEdit:9037703] Orlic-Milacic, Marija, 2018-02-20
eventOf	[Pathway:R-HSA-9032759] NTRK2 activates RAC1 - Homo sapiens
input	[SimpleEntity:R-ALL-29438] GTP [cytosol] [Complex:R-HSA-5674631] RAC1:GDP [plasma membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9032772] Dock3 induces axonal outgrowth by stimulating membrane recruitment of the WAVE complex
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	DOCK3 activates RAC1
orthologousEvent	[BlackBoxEvent:R-GGA-9032798] DOCK3 activates RAC1 - Gallus gallus [BlackBoxEvent:R-SSC-9032798] DOCK3 activates RAC1 - Sus scrofa [BlackBoxEvent:R-CFA-9032798] DOCK3 activates RAC1 - Canis familiaris [BlackBoxEvent:R-RNO-9032798] DOCK3 activates RAC1 - Rattus norvegicus [BlackBoxEvent:R-MMU-9032798] DOCK3 activates RAC1 - Mus musculus
output	[SimpleEntity:R-ALL-29420] GDP [cytosol] [Complex:R-HSA-442641] RAC1:GTP [plasma membrane]
precedingEvent	[BlackBoxEvent:R-HSA-9032761] DOCK3 binds FYN associated with NTRK2 - Homo sapiens
releaseDate	2018-03-21
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9037707] Antila, Hanna, 2018-02-13 [InstanceEdit:9037710] Castr�n, Eero, 2018-02-13
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-9032798
summation	[Summation:9032811] DOCK3 activates RAC1 and contributes to recruitment of the R...

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(hasEvent)

[Pathway:R-HSA-9032759] NTRK2 activates RAC1

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