Reactome | RAC1:GTP [plasma membrane]

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RAC1:GTP [plasma membrane] Show undefined attributes

compartment	[Compartment:876] plasma membrane
componentOf	[Complex:R-DRE-9013182] RAC1:GTP:RAC1 effectors [plasma membrane] - Danio rerio [Complex:R-DRE-5668712] NOX1 complex:RAC1:GTP [plasma membrane] - Danio rerio [Complex:R-DRE-2029148] p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] - Danio rerio [Complex:R-DRE-2029147] WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] - Danio rerio
consumedByEvent	[BlackBoxEvent:R-DRE-9691168] RAC1 translocates to the endoplasmic reticulum membrane - Danio rerio [Reaction:R-DRE-9013144] RAC1 GAPs stimulate RAC1 GTPase activity - Danio rerio [Reaction:R-DRE-9013145] RAC1 binds effectors at the plasma membrane - Danio rerio [Reaction:R-DRE-5668714] RAC1:GTP binds NOX1 complex - Danio rerio [Reaction:R-DRE-5668735] RAC1:GTP binds NOX3 complex - Danio rerio [Reaction:R-DRE-5218827] NADPH oxidase 2 (NOX2) complex binds RAC1 - Danio rerio [Reaction:R-DRE-400682] Active Rac1 interacts with Plexin-B1:Sema4D - Danio rerio
created	[InstanceEdit:10559787] Weiser, Joel, 2026-03-16
dbId	10567498
displayName	RAC1:GTP [plasma membrane]
hasComponent	[SimpleEntity:R-ALL-29438] GTP [cytosol] [EntityWithAccessionedSequence:R-DRE-351141] rac1a [plasma membrane]
inDisease	false
inferredFrom	[Complex:R-HSA-442641] RAC1:GTP [plasma membrane] - Homo sapiens
maxDepth	2
memberOf	[CandidateSet:R-DRE-9959034] RAC1:GTP,(CDC42:GTP) [plasma membrane] - Danio rerio [DefinedSet:R-DRE-389778] CDC42:GTP, RAC1:GTP [plasma membrane] - Danio rerio
name	RAC1:GTP
producedByEvent	[Reaction:R-DRE-9013143] RAC1 GEFs activate RAC1 - Danio rerio [Reaction:R-DRE-4093336] p-TIAM1 exchanges GTP for GDP on RAC1, activating it - Danio rerio [Reaction:R-DRE-3928628] VAV exchanges GTP for GDP on RAC1, activating it - Danio rerio [Reaction:R-DRE-3928642] TIAM1 exchanges GTP for GDP on RAC1, activating it - Danio rerio [Reaction:R-DRE-5218839] DOCK180:ELMO exchanges GTP for GDP, activating RAC1 - Danio rerio [Reaction:R-DRE-8848618] Activation of RAC1 by the PXN:CRK complex - Danio rerio
schemaClass	Complex
species	[Species:68323] Danio rerio
stId	R-DRE-442641
summation	[Summation:9984903] This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.

Referrals

(input)	[BlackBoxEvent:R-DRE-9691168] RAC1 translocates to the endoplasmic reticulum membrane [Reaction:R-DRE-9013144] RAC1 GAPs stimulate RAC1 GTPase activity [Reaction:R-DRE-9013145] RAC1 binds effectors at the plasma membrane [Reaction:R-DRE-5668714] RAC1:GTP binds NOX1 complex [Reaction:R-DRE-5668735] RAC1:GTP binds NOX3 complex [Reaction:R-DRE-5218827] NADPH oxidase 2 (NOX2) complex binds RAC1 [Reaction:R-DRE-400682] Active Rac1 interacts with Plexin-B1:Sema4D
(output)	[Reaction:R-DRE-9013143] RAC1 GEFs activate RAC1 [Reaction:R-DRE-4093336] p-TIAM1 exchanges GTP for GDP on RAC1, activating it [Reaction:R-DRE-3928628] VAV exchanges GTP for GDP on RAC1, activating it [Reaction:R-DRE-3928642] TIAM1 exchanges GTP for GDP on RAC1, activating it [Reaction:R-DRE-5218839] DOCK180:ELMO exchanges GTP for GDP, activating RAC1 [Reaction:R-DRE-8848618] Activation of RAC1 by the PXN:CRK complex
(hasComponent)	[Complex:R-DRE-9013182] RAC1:GTP:RAC1 effectors [plasma membrane] [Complex:R-DRE-5668712] NOX1 complex:RAC1:GTP [plasma membrane] [Complex:R-DRE-5668738] NOX3 complex:RAC1:GTP [plasma membrane] [Complex:R-DRE-5218774] NOX2 complex:RAC1:GTP [plasma membrane] [Complex:R-DRE-400679] Sema4D:pPlexin-B1:Met:RAC1-GTP [plasma membrane] [Complex:R-DRE-5663231] RAC1:GTP:FMNL1 [plasma membrane] [Complex:R-DRE-399872] Sema3A:Nrp-1:pPlexinA:Fyn:Fes:Rac-1-GTP [plasma membrane] [Complex:R-DRE-2029147] WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] [Complex:R-DRE-2130182] p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] [Complex:R-DRE-2029148] p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol]
(activeUnit)	[CatalystActivity:10615532] GTPase activity of SRGAP2:RAC1:GTP:FMNL1:Profilin:G-actin [plasma membrane]
(hasMember)	[DefinedSet:R-DRE-389778] CDC42:GTP, RAC1:GTP [plasma membrane] [CandidateSet:R-DRE-9959034] RAC1:GTP,(CDC42:GTP) [plasma membrane] [DefinedSet:R-DRE-9615275] RAC1:GTP,RAC2:GTP,RHOG:GTP [plasma membrane]
(inferredTo)	[Complex:R-HSA-442641] RAC1:GTP [plasma membrane]

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