Reactome | FMNL1 binds RAC1:GTP

Schema > Reaction > Entries

FMNL1 binds RAC1:GTP Show undefined attributes

authored	[InstanceEdit:5628889] Orlic-Milacic, Marija, 2014-10-24 [InstanceEdit:5668821] Rivero Crespo, Francisco, 2014-12-26
category	binding
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:5663233] Orlic-Milacic, Marija, 2015-01-16
dbId	5663232
displayName	FMNL1 binds RAC1:GTP
edited	[InstanceEdit:5671747] Orlic-Milacic, Marija, 2015-02-02
eventOf	[Pathway:R-HSA-5663220] RHO GTPases Activate Formins - Homo sapiens
followingEvent	[Reaction:R-HSA-5665659] RAC1:GTP:FMNL1 binds profilin:G-actin - Homo sapiens
inferredFrom	[Reaction:R-MMU-5663241] Fmnl1 binds Rac1:GTP - Mus musculus
input	[Complex:R-HSA-5665949] FMNL1 [cytosol] [Complex:R-HSA-442641] RAC1:GTP [plasma membrane]
isChimeric	false
isInDisease	false
isInferred	true
literatureReference	[LiteratureReference:5663237] FRL, a novel formin-related protein, binds to Rac and regulates cell motility and survival of macrophages [LiteratureReference:5663236] The regulation of mDia1 by autoinhibition and its release by Rho*GTP [LiteratureReference:5663227] Structural and mechanistic insights into the interaction between Rho and mammalian Dia [LiteratureReference:5665691] FMNL1 promotes proliferation and migration of leukemia cells [LiteratureReference:5665716] Formin-like 1 (FMNL1) is regulated by N-terminal myristoylation and induces polarized membrane blebbing [LiteratureReference:5665948] Crystal structures of a Formin Homology-2 domain reveal a tethered dimer architecture [LiteratureReference:5665955] Formins as effector proteins of Rho GTPases
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	FMNL1 binds RAC1:GTP
output	[Complex:R-HSA-5663231] RAC1:GTP:FMNL1 [plasma membrane]
precedingEvent	[Reaction:R-HSA-8848618] Activation of RAC1 by the PXN:CRK complex - Homo sapiens
releaseDate	2015-03-19
reviewStatus	[ReviewStatus:9821382] five stars
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-5663232
summation	[Summation:5663228] FMNL1 (formin-like protein 1) binds the active, GTP-bound, f...

Referrals

(hasEvent)	[Pathway:R-HSA-5663220] RHO GTPases Activate Formins
(precedingEvent)	[Reaction:R-HSA-5665659] RAC1:GTP:FMNL1 binds profilin:G-actin
(inferredTo)	[Reaction:R-MMU-5663241] Fmnl1 binds Rac1:GTP