Reactome | Activation of RAC1 by CRKII:DOCK180:ELMO

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Activation of RAC1 by CRKII:DOCK180:ELMO Show undefined attributes

authored	[InstanceEdit:2029483] Garapati, P V, 2012-01-04
catalystActivity	[CatalystActivity:2029256] guanyl-nucleotide exchange factor activity of CRKII:DOCK180:ELMO complex recruited to phagocytic cup [plasma membrane]
catalystActivityReference	[CatalystActivityReference:9643802] guanyl-nucleotide exchange factor activity of CRKII:DOCK180:ELMO complex recruited to phagocytic cup [plasma membrane] Unconventional Rac-GEF activity is mediated through the Dock180-ELMO complex
category	transition
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol [Compartment:984] extracellular region
created	[InstanceEdit:2029463] Garapati, P V, 2012-01-04
dbId	2029467
displayName	Activation of RAC1 by CRKII:DOCK180:ELMO
edited	[InstanceEdit:2029483] Garapati, P V, 2012-01-04
eventOf	[Pathway:R-HSA-2029482] Regulation of actin dynamics for phagocytic cup formation - Homo sapiens
input	[SimpleEntity:R-ALL-29438] GTP [cytosol] [Complex:R-HSA-5674631] RAC1:GDP [plasma membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:2028903] Role of CrkII in Fcgamma receptor-mediated phagocytosis
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	Activation of RAC1 by CRKII:DOCK180:ELMO
orthologousEvent	[Reaction:R-MMU-2029467] Activation of RAC1 by CRKII:DOCK180:ELMO - Mus musculus [Reaction:R-GGA-2029467] Activation of RAC1 by CRKII:DOCK180:ELMO - Gallus gallus [Reaction:R-SSC-2029467] Activation of RAC1 by CRKII:DOCK180:ELMO - Sus scrofa [Reaction:R-CFA-2029467] Activation of RAC1 by CRKII:DOCK180:ELMO - Canis familiaris [Reaction:R-RNO-2029467] Activation of RAC1 by CRKII:DOCK180:ELMO - Rattus norvegicus
output	[SimpleEntity:R-ALL-29420] GDP [cytosol] [Complex:R-HSA-442641] RAC1:GTP [plasma membrane]
releaseDate	2013-03-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2248842] Rosales, C, 2012-05-14
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-2029467
summation	[Summation:2197693] RAC1 is activated from inactive GDP-bound state to active GT...
updateTrackers	[UpdateTracker:9785437] Update Tracker - [Reaction:2029467] Activation of RAC1 by CRKII:DOCK180:ELMO - v52:[add_removeInput]

Referrals

(updatedInstance)	[UpdateTracker:9785437] Update Tracker - [Reaction:2029467] Activation of RAC1 by CRKII:DOCK180:ELMO - v52:[add_removeInput]
(hasEvent)	[Pathway:R-HSA-2029482] Regulation of actin dynamics for phagocytic cup formation

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