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Schema
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Reaction
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Entries
TIAM1 exchanges GTP for GDP on RAC1, activating it
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authored
[InstanceEdit:3928653] Garapati, P V, 2013-07-22
catalystActivity
[CatalystActivity:3928652] guanyl-nucleotide exchange factor activity of EFNAs:p-EPHAs:SFKs:TIAM1 [plasma membrane]
catalystActivityReference
[CatalystActivityReference:9644013] guanyl-nucleotide exchange factor activity of EFNAs:p-EPHAs:SFKs:TIAM1 [plasma membrane] EphA8-ephrinA5 signaling and clathrin-mediated endocytosis is regulated by Tiam-1, a Rac-specific guanine nucleotide exchange factor
category
transition
compartment
[Compartment:876] plasma membrane
[Compartment:70101] cytosol
created
[InstanceEdit:3928638] Garapati, P V, 2013-07-22
dbId
3928642
displayName
TIAM1 exchanges GTP for GDP on RAC1, activating it
edited
[InstanceEdit:3928653] Garapati, P V, 2013-07-22
eventOf
[Pathway:R-HSA-3928665] EPH-ephrin mediated repulsion of cells - Homo sapiens
input
[SimpleEntity:R-ALL-29438] GTP [cytosol]
[Complex:R-HSA-445010] RAC1:GDP [cytosol]
isChimeric
false
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:3928096] EphA8-ephrinA5 signaling and clathrin-mediated endocytosis is regulated by Tiam-1, a Rac-specific guanine nucleotide exchange factor
maxDepth
1
modified
[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name
TIAM1 exchanges GTP for GDP on RAC1, activating it
orthologousEvent
[Reaction:R-CEL-3928642] TIAM1 exchanges GTP for GDP on RAC1, activating it - Caenorhabditis elegans
[Reaction:R-DME-3928642] TIAM1 exchanges GTP for GDP on RAC1, activating it - Drosophila melanogaster
[Reaction:R-GGA-3928642] TIAM1 exchanges GTP for GDP on RAC1, activating it - Gallus gallus
[Reaction:R-DRE-3928642] TIAM1 exchanges GTP for GDP on RAC1, activating it - Danio rerio
[Reaction:R-SSC-3928642] TIAM1 exchanges GTP for GDP on RAC1, activating it - Sus scrofa
[Reaction:R-CFA-3928642] TIAM1 exchanges GTP for GDP on RAC1, activating it - Canis familiaris
[Reaction:R-RNO-3928642] TIAM1 exchanges GTP for GDP on RAC1, activating it - Rattus norvegicus
[Reaction:R-MMU-3928642] TIAM1 exchanges GTP for GDP on RAC1, activating it - Mus musculus
output
[SimpleEntity:R-ALL-29420] GDP [cytosol]
[Complex:R-HSA-442641] RAC1:GTP [plasma membrane]
precedingEvent
[Reaction:R-HSA-4093327] EPHA binds TIAM1 - Homo sapiens
releaseDate
2014-06-10
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:5490284] Ip, Nancy Y, 2014-05-19
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-3928642
summation
[Summation:3928285] Activation of EPH receptors triggers the local activation of...
Referrals
(hasEvent)
[Pathway:R-HSA-3928665] EPH-ephrin mediated repulsion of cells
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