Reactome | Metabolism of folate and pterines

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Metabolism of folate and pterines Show undefined attributes

created	[InstanceEdit:196747] Jassal, B, 2007-04-24 08:38:46
dbId	196757
displayName	Metabolism of folate and pterines
eventOf	[Pathway:R-HSA-196849] Metabolism of water-soluble vitamins and cofactors - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:25846] folic acid metabolic process
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-HSA-8940134] FOLR2 binds FOLA - Homo sapiens [BlackBoxEvent:R-HSA-8942344] FOLR2 transports FOLA from extracellular region to cytosol - Homo sapiens [Reaction:R-HSA-200729] SLC46A1 transports FOLA from extracellular region to cytosol - Homo sapiens [Reaction:R-HSA-200646] Cytosolic folate export across the plasma membrane - Homo sapiens [Reaction:R-HSA-200652] SLC19A1 transports 5-methyl-THF from extracellular region to cytosol - Homo sapiens [Reaction:R-HSA-197963] DHFR2 reduces FOLA to DHF - Homo sapiens [Reaction:R-HSA-9709098] DHFR dimer reduces FOLA to DHF - Homo sapiens [Reaction:R-HSA-9709109] DHFR dimer binds DHFR inhibitors - Homo sapiens [Reaction:R-HSA-197972] DHF is reduced to tetrahydrofolate (THF) - Homo sapiens [Reaction:R-HSA-197958] FPGS-2 transforms THF to THFPG - Homo sapiens [Reaction:R-HSA-200681] FPGS-2 transforms 5-methyl-THF to 5-methyl-THFPG - Homo sapiens [Reaction:R-HSA-200680] SLC25A32 transports THF from cytosol to mitochondrial matrix - Homo sapiens [Reaction:R-HSA-200720] SLC25A32 transports THF from mitochondrial matrix to cytosol - Homo sapiens [Reaction:R-HSA-200682] Mitochondrial FPGS-1 transforms THF to THFPG - Homo sapiens [Reaction:R-HSA-5694137] PXLP-K280-SHMT2 tetramer transfers CH2OH group to Gly to form L-Ser - Homo sapiens [Reaction:R-HSA-5696839] MTHFD1L dimer ligates HCOOH to THF to form 10-formyl-THF - Homo sapiens [Reaction:R-HSA-200711] MTHFD1 dimer ligates HCOOH to THFPG to form 10-formyl-THFPG - Homo sapiens [Reaction:R-HSA-200661] MTHFD1 dimer transforms 10-formyl-THFPG to 5,10-methenyl-THFPG - Homo sapiens [Reaction:R-HSA-200718] MTHFD1 dimer dehydrogenates 5,10-methenyl-THFPG to 5,10-methylene-THFPG - Homo sapiens [Reaction:R-HSA-200735] SHMT1 tetramer transfers hydroxymethyl group to THFPG to form 5,10-methylene-THFPG - Homo sapiens [Reaction:R-HSA-200676] MTHFR dimer reduces 5,10-methylene-THFPG to 5-methyl-THFPG - Homo sapiens [Reaction:R-HSA-200651] 5,10-methyleneTHF polyglutamate + glycine <=> tetrahydrofolate polyglutamate (THF polyglutamate) + serine - Homo sapiens [Reaction:R-HSA-200644] 5,10-methyleneTHF polyglutamate + NADP+ <=> 5,10-methenylTHF polyglutamate + NADPH + H+ - Homo sapiens [Reaction:R-HSA-200740] 5,10-methenylTHF polyglutamate + H2O <=> 10-formylTHF polyglutamate - Homo sapiens [Reaction:R-HSA-6808496] ALDH1L1 dehydrogenates 10-formyl-THFPG to THFPG - Homo sapiens [Reaction:R-HSA-6801328] MTHFD2, D2L oxidise 5,10-methylene-THF to 5,10-methenyl-THF - Homo sapiens [Reaction:R-HSA-6801462] MTHFD2, D2L oxidise 5,10-methenyl-THF to 10-formyl-THF - Homo sapiens [Reaction:R-HSA-6808487] ALDH1L2 dehydrogenates 10-formyl-THFPG to THFPG - Homo sapiens [Reaction:R-HSA-6801456] MTHFD1L transforms 10-formyl-THF to HCOOH and THF - Homo sapiens [BlackBoxEvent:R-HSA-6803255] HCOOH translocated from mitochondrial matrix to cytosol - Homo sapiens [Reaction:R-HSA-6801342] MTHFS transforms 5-formyl-THFPG to 5,10-methenyl-THFPG - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2022-06-09
literatureReference	[LiteratureReference:197979] Folic acid: nutritional biochemistry, molecular biology, and role in disease processes [LiteratureReference:197973] Folate and vitamin B12
maxDepth	2
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	Metabolism of folate and pterines
orthologousEvent	[Pathway:R-MMU-196757] Metabolism of folate and pterines - Mus musculus [Pathway:R-RNO-196757] Metabolism of folate and pterines - Rattus norvegicus [Pathway:R-CFA-196757] Metabolism of folate and pterines - Canis familiaris [Pathway:R-BTA-196757] Metabolism of folate and pterines - Bos taurus [Pathway:R-SSC-196757] Metabolism of folate and pterines - Sus scrofa [Pathway:R-DRE-196757] Metabolism of folate and pterines - Danio rerio [Pathway:R-XTR-196757] Metabolism of folate and pterines - Xenopus tropicalis [Pathway:R-GGA-196757] Metabolism of folate and pterines - Gallus gallus [Pathway:R-DME-196757] Metabolism of folate and pterines - Drosophila melanogaster [Pathway:R-CEL-196757] Metabolism of folate and pterines - Caenorhabditis elegans [Pathway:R-DDI-196757] Metabolism of folate and pterines - Dictyostelium discoideum [Pathway:R-SPO-196757] Metabolism of folate and pterines - Schizosaccharomyces pombe [Pathway:R-SCE-196757] Metabolism of folate and pterines - Saccharomyces cerevisiae [Pathway:R-PFA-196757] Metabolism of folate and pterines - Plasmodium falciparum
releaseDate	2007-08-21
reviewStatus	[ReviewStatus:9821382] five stars
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-196757
summation	[Summation:200700] Folates are essential cofactors that provide one-carbon moie...
updateTrackers	[UpdateTracker:9784354] Update Tracker - [Pathway:196757] Metabolism of folate and pterines - v54:[addHasEvent] [UpdateTracker:9783612] Update Tracker - [Pathway:196757] Metabolism of folate and pterines - v56:[addHasEvent] [UpdateTracker:9774711] Update Tracker - [Pathway:196757] Metabolism of folate and pterines - v81:[addHasEvent] [UpdateTracker:9783781] Update Tracker - [Pathway:196757] Metabolism of folate and pterines - v55:[updateContainedRLE] [UpdateTracker:9782697] Update Tracker - [Pathway:196757] Metabolism of folate and pterines - v59:[addHasEvent] [UpdateTracker:9776388] Update Tracker - [Pathway:196757] Metabolism of folate and pterines - v76:[addHasEvent, updateContainedRLE]

Referrals

(hasEvent)

[Pathway:R-HSA-196849] Metabolism of water-soluble vitamins and cofactors

(updatedInstance)

[UpdateTracker:9784354] Update Tracker - [Pathway:196757] Metabolism of folate and pterines - v54:[addHasEvent]
[UpdateTracker:9783612] Update Tracker - [Pathway:196757] Metabolism of folate and pterines - v56:[addHasEvent]
[UpdateTracker:9774711] Update Tracker - [Pathway:196757] Metabolism of folate and pterines - v81:[addHasEvent]
[UpdateTracker:9783781] Update Tracker - [Pathway:196757] Metabolism of folate and pterines - v55:[updateContainedRLE]
[UpdateTracker:9782697] Update Tracker - [Pathway:196757] Metabolism of folate and pterines - v59:[addHasEvent]
[UpdateTracker:9776388] Update Tracker - [Pathway:196757] Metabolism of folate and pterines - v76:[addHasEvent, updateContainedRLE]

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