Reactome | MTHFS transforms 5-formyl-THFPG to 5,10-methenyl-THFPG

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MTHFS transforms 5-formyl-THFPG to 5,10-methenyl-THFPG Show undefined attributes

authored	[InstanceEdit:6801327] Jassal, Bijay, 2015-10-01
catalystActivity	[CatalystActivity:6801334] 5-formyltetrahydrofolate cyclo-ligase activity of MTHFS [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:6801327] Jassal, Bijay, 2015-10-01
dbId	6801342
displayName	MTHFS transforms 5-formyl-THFPG to 5,10-methenyl-THFPG
edited	[InstanceEdit:6801327] Jassal, Bijay, 2015-10-01
eventOf	[Pathway:R-HSA-196757] Metabolism of folate and pterines - Homo sapiens
input	[SimpleEntity:R-ALL-6803257] 5-formyl-THFPG [cytosol] [SimpleEntity:R-ALL-113592] ATP [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:6801337] Cloning and characterization of the human 5,10-methenyltetrahydrofolate synthetase-encoding cDNA [LiteratureReference:6803261] Human liver methenyltetrahydrofolate synthetase: improved purification and increased affinity for folate polyglutamate substrates
maxDepth	1
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	MTHFS transforms 5-formyl-THFPG to 5,10-methenyl-THFPG
orthologousEvent	[Reaction:R-PFA-6801342] MTHFS transforms 5-formyl-THFPG to 5,10-methenyl-THFPG - Plasmodium falciparum [Reaction:R-SCE-6801342] MTHFS transforms 5-formyl-THFPG to 5,10-methenyl-THFPG - Saccharomyces cerevisiae [Reaction:R-SPO-6801342] MTHFS transforms 5-formyl-THFPG to 5,10-methenyl-THFPG - Schizosaccharomyces pombe [Reaction:R-CEL-6801342] MTHFS transforms 5-formyl-THFPG to 5,10-methenyl-THFPG - Caenorhabditis elegans [Reaction:R-DME-6801342] MTHFS transforms 5-formyl-THFPG to 5,10-methenyl-THFPG - Drosophila melanogaster [Reaction:R-GGA-6801342] MTHFS transforms 5-formyl-THFPG to 5,10-methenyl-THFPG - Gallus gallus [Reaction:R-XTR-6801342] MTHFS transforms 5-formyl-THFPG to 5,10-methenyl-THFPG - Xenopus tropicalis [Reaction:R-DRE-6801342] MTHFS transforms 5-formyl-THFPG to 5,10-methenyl-THFPG - Danio rerio [Reaction:R-SSC-6801342] MTHFS transforms 5-formyl-THFPG to 5,10-methenyl-THFPG - Sus scrofa [Reaction:R-BTA-6801342] MTHFS transforms 5-formyl-THFPG to 5,10-methenyl-THFPG - Bos taurus [Reaction:R-CFA-6801342] MTHFS transforms 5-formyl-THFPG to 5,10-methenyl-THFPG - Canis familiaris [Reaction:R-RNO-6801342] MTHFS transforms 5-formyl-THFPG to 5,10-methenyl-THFPG - Rattus norvegicus [Reaction:R-MMU-6801342] MTHFS transforms 5-formyl-THFPG to 5,10-methenyl-THFPG - Mus musculus
output	[SimpleEntity:R-ALL-200640] 5,10-methenyl-THFPG [cytosol] [SimpleEntity:R-ALL-29370] ADP [cytosol] [SimpleEntity:R-ALL-70106] H+ [cytosol] [SimpleEntity:R-ALL-29372] Pi [cytosol]
releaseDate	2016-03-23
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8851787] D'Eustachio, Peter, 2016-01-11
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-6801342
summation	[Summation:6801339] Cytosolic 5-formyltetrahydrofolate cyclo-ligase (MTHFS) cata...

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[Pathway:R-HSA-196757] Metabolism of folate and pterines