Reactome | MTHFR dimer reduces 5,10-methylene-THFPG to 5-methyl-THFPG

Schema > Reaction > Entries

MTHFR dimer reduces 5,10-methylene-THFPG to 5-methyl-THFPG Show undefined attributes

catalystActivity	[CatalystActivity:200678] methylenetetrahydrofolate reductase [NAD(P)H] activity of MTHFR dimer [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:200727] D'Eustachio, P, 2007-07-23 20:23:04
dbId	200676
displayName	MTHFR dimer reduces 5,10-methylene-THFPG to 5-methyl-THFPG
eventOf	[Pathway:R-HSA-196757] Metabolism of folate and pterines - Homo sapiens
followingEvent	[Reaction:R-HSA-174374] MTR transfers CH3 from MeCbl to HCYS - Homo sapiens
input	[SimpleEntity:R-ALL-200739] 5,10-methylene-THFPG [cytosol] [SimpleEntity:R-ALL-70106] H+ [cytosol] [SimpleEntity:R-ALL-29364] NADPH [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:200714] Seven novel mutations in the methylenetetrahydrofolate reductase gene and genotype/phenotype correlations in severe methylenetetrahydrofolate reductase deficiency
maxDepth	1
modified	[InstanceEdit:11080360] Weiser, Joel, 2026-03-16
name	MTHFR dimer reduces 5,10-methylene-THFPG to 5-methyl-THFPG 5,10-methyleneTHF polyglutamate + NADPH + H+ => 5-methylTHF polyglutamate + NADP+
orthologousEvent	[Reaction:R-RNO-200676] MTHFR dimer reduces 5,10-methylene-THFPG to 5-methyl-THFPG - Rattus norvegicus [Reaction:R-SCE-200676] MTHFR dimer reduces 5,10-methylene-THFPG to 5-methyl-THFPG - Saccharomyces cerevisiae [Reaction:R-SPO-200676] MTHFR dimer reduces 5,10-methylene-THFPG to 5-methyl-THFPG - Schizosaccharomyces pombe [Reaction:R-DDI-200676] MTHFR dimer reduces 5,10-methylene-THFPG to 5-methyl-THFPG - Dictyostelium discoideum [Reaction:R-CEL-200676] MTHFR dimer reduces 5,10-methylene-THFPG to 5-methyl-THFPG - Caenorhabditis elegans [Reaction:R-DME-200676] MTHFR dimer reduces 5,10-methylene-THFPG to 5-methyl-THFPG - Drosophila melanogaster [Reaction:R-GGA-200676] MTHFR dimer reduces 5,10-methylene-THFPG to 5-methyl-THFPG - Gallus gallus [Reaction:R-XTR-200676] MTHFR dimer reduces 5,10-methylene-THFPG to 5-methyl-THFPG - Xenopus tropicalis [Reaction:R-DRE-200676] MTHFR dimer reduces 5,10-methylene-THFPG to 5-methyl-THFPG - Danio rerio [Reaction:R-SSC-200676] MTHFR dimer reduces 5,10-methylene-THFPG to 5-methyl-THFPG - Sus scrofa [Reaction:R-BTA-200676] MTHFR dimer reduces 5,10-methylene-THFPG to 5-methyl-THFPG - Bos taurus [Reaction:R-CFA-200676] MTHFR dimer reduces 5,10-methylene-THFPG to 5-methyl-THFPG - Canis familiaris [Reaction:R-MMU-200676] MTHFR dimer reduces 5,10-methylene-THFPG to 5-methyl-THFPG - Mus musculus
output	[SimpleEntity:R-ALL-174404] 5-methyl-THFPG [cytosol] [SimpleEntity:R-ALL-29366] NADP+ [cytosol]
precedingEvent	[Reaction:R-HSA-200718] MTHFD1 dimer dehydrogenates 5,10-methenyl-THFPG to 5,10-methylene-THFPG - Homo sapiens [Reaction:R-HSA-200735] SHMT1 tetramer transfers hydroxymethyl group to THFPG to form 5,10-methylene-THFPG - Homo sapiens
releaseDate	2007-08-21
reviewStatus	[ReviewStatus:9821382] five stars
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-200676
summation	[Summation:200725] Cytosolic MTHFR dimer catalyzes the reaction of 5,10-methyle...

Referrals

(hasEvent)	[Pathway:R-HSA-196757] Metabolism of folate and pterines
(precedingEvent)	[Reaction:R-HSA-174374] MTR transfers CH3 from MeCbl to HCYS