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Schema
>
Reaction
>
Entries
MTHFD1L transforms 10-formyl-THF to HCOOH and THF
Show undefined attributes
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authored
[InstanceEdit:6801455] Jassal, Bijay, 2015-10-02
catalystActivity
[CatalystActivity:5696827] formate-tetrahydrofolate ligase activity of MTHFD1L dimer [mitochondrial matrix]
category
transition
compartment
[Compartment:5460] mitochondrial matrix
created
[InstanceEdit:6801455] Jassal, Bijay, 2015-10-02
dbId
6801456
displayName
MTHFD1L transforms 10-formyl-THF to HCOOH and THF
edited
[InstanceEdit:6801455] Jassal, Bijay, 2015-10-02
eventOf
[Pathway:R-HSA-196757] Metabolism of folate and pterines - Homo sapiens
followingEvent
[BlackBoxEvent:R-HSA-6803255] HCOOH translocated from mitochondrial matrix to cytosol - Homo sapiens
input
[SimpleEntity:R-ALL-5389850] 10-formyl-THF [mitochondrial matrix]
[SimpleEntity:R-ALL-113581] ADP [mitochondrial matrix]
[SimpleEntity:R-ALL-113548] Pi [mitochondrial matrix]
isChimeric
false
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:5696837] Human mitochondrial C1-tetrahydrofolate synthase: gene structure, tissue distribution of the mRNA, and immunolocalization in Chinese hamster ovary calls
[LiteratureReference:5696846] Enzymatic characterization of human mitochondrial C1-tetrahydrofolate synthase
[LiteratureReference:6785950] Mitochondrial C1-tetrahydrofolate synthase (MTHFD1L) supports the flow of mitochondrial one-carbon units into the methyl cycle in embryos
modified
[InstanceEdit:10931649] Wright, Adam, 2024-03-08
name
MTHFD1L transforms 10-formyl-THF to HCOOH and THF
orthologousEvent
[Reaction:R-PFA-6801456] MTHFD1L transforms 10-formyl-THF to HCOOH and THF - Plasmodium falciparum
[Reaction:R-SCE-6801456] MTHFD1L transforms 10-formyl-THF to HCOOH and THF - Saccharomyces cerevisiae
[Reaction:R-SPO-6801456] MTHFD1L transforms 10-formyl-THF to HCOOH and THF - Schizosaccharomyces pombe
[Reaction:R-DDI-6801456] MTHFD1L transforms 10-formyl-THF to HCOOH and THF - Dictyostelium discoideum
[Reaction:R-CEL-6801456] MTHFD1L transforms 10-formyl-THF to HCOOH and THF - Caenorhabditis elegans
[Reaction:R-DME-6801456] MTHFD1L transforms 10-formyl-THF to HCOOH and THF - Drosophila melanogaster
[Reaction:R-GGA-6801456] MTHFD1L transforms 10-formyl-THF to HCOOH and THF - Gallus gallus
[Reaction:R-XTR-6801456] MTHFD1L transforms 10-formyl-THF to HCOOH and THF - Xenopus tropicalis
[Reaction:R-DRE-6801456] MTHFD1L transforms 10-formyl-THF to HCOOH and THF - Danio rerio
[Reaction:R-SSC-6801456] MTHFD1L transforms 10-formyl-THF to HCOOH and THF - Sus scrofa
[Reaction:R-BTA-6801456] MTHFD1L transforms 10-formyl-THF to HCOOH and THF - Bos taurus
[Reaction:R-CFA-6801456] MTHFD1L transforms 10-formyl-THF to HCOOH and THF - Canis familiaris
[Reaction:R-RNO-6801456] MTHFD1L transforms 10-formyl-THF to HCOOH and THF - Rattus norvegicus
[Reaction:R-MMU-6801456] MTHFD1L transforms 10-formyl-THF to HCOOH and THF - Mus musculus
output
[SimpleEntity:R-ALL-113593] ATP [mitochondrial matrix]
[SimpleEntity:R-ALL-6801451] HCOOH [mitochondrial matrix]
[SimpleEntity:R-ALL-200671] THF [mitochondrial matrix]
precedingEvent
[Reaction:R-HSA-6801462] MTHFD2, D2L oxidise 5,10-methenyl-THF to 10-formyl-THF - Homo sapiens
releaseDate
2016-03-23
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:8851787] D'Eustachio, Peter, 2016-01-11
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-6801456
summation
[Summation:6801457] All C1-tetrahydrofolate (C1-THF) synthases characterised to ...
Referrals
(hasEvent)
[Pathway:R-HSA-196757] Metabolism of folate and pterines
(precedingEvent)
[BlackBoxEvent:R-HSA-6803255] HCOOH translocated from mitochondrial matrix to cytosol
(reverseReaction)
[Reaction:R-HSA-5696839] MTHFD1L dimer ligates HCOOH to THF to form 10-formyl-THF
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