Reactome | MTHFD1L dimer ligates HCOOH to THF to form 10-formyl-THF

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MTHFD1L dimer ligates HCOOH to THF to form 10-formyl-THF Show undefined attributes

authored	[InstanceEdit:5696828] Jassal, Bijay, 2015-06-01
catalystActivity	[CatalystActivity:5696827] formate-tetrahydrofolate ligase activity of MTHFD1L dimer [mitochondrial matrix]
category	transition
compartment	[Compartment:5460] mitochondrial matrix
created	[InstanceEdit:5696828] Jassal, Bijay, 2015-06-01
dbId	5696839
displayName	MTHFD1L dimer ligates HCOOH to THF to form 10-formyl-THF
edited	[InstanceEdit:5696828] Jassal, Bijay, 2015-06-01
eventOf	[Pathway:R-HSA-196757] Metabolism of folate and pterines - Homo sapiens
followingEvent	[Reaction:R-HSA-6801328] MTHFD2, D2L oxidise 5,10-methylene-THF to 5,10-methenyl-THF - Homo sapiens
input	[SimpleEntity:R-ALL-113593] ATP [mitochondrial matrix] [SimpleEntity:R-ALL-6801451] HCOOH [mitochondrial matrix] [SimpleEntity:R-ALL-200671] THF [mitochondrial matrix]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:5696837] Human mitochondrial C1-tetrahydrofolate synthase: gene structure, tissue distribution of the mRNA, and immunolocalization in Chinese hamster ovary calls [LiteratureReference:5696846] Enzymatic characterization of human mitochondrial C1-tetrahydrofolate synthase [LiteratureReference:6785950] Mitochondrial C1-tetrahydrofolate synthase (MTHFD1L) supports the flow of mitochondrial one-carbon units into the methyl cycle in embryos
maxDepth	1
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	MTHFD1L dimer ligates HCOOH to THF to form 10-formyl-THF
orthologousEvent	[Reaction:R-PFA-5696839] MTHFD1L dimer ligates HCOOH to THF to form 10-formyl-THF - Plasmodium falciparum [Reaction:R-SCE-5696839] MTHFD1L dimer ligates HCOOH to THF to form 10-formyl-THF - Saccharomyces cerevisiae [Reaction:R-SPO-5696839] MTHFD1L dimer ligates HCOOH to THF to form 10-formyl-THF - Schizosaccharomyces pombe [Reaction:R-DDI-5696839] MTHFD1L dimer ligates HCOOH to THF to form 10-formyl-THF - Dictyostelium discoideum [Reaction:R-CEL-5696839] MTHFD1L dimer ligates HCOOH to THF to form 10-formyl-THF - Caenorhabditis elegans [Reaction:R-DME-5696839] MTHFD1L dimer ligates HCOOH to THF to form 10-formyl-THF - Drosophila melanogaster [Reaction:R-GGA-5696839] MTHFD1L dimer ligates HCOOH to THF to form 10-formyl-THF - Gallus gallus [Reaction:R-XTR-5696839] MTHFD1L dimer ligates HCOOH to THF to form 10-formyl-THF - Xenopus tropicalis [Reaction:R-DRE-5696839] MTHFD1L dimer ligates HCOOH to THF to form 10-formyl-THF - Danio rerio [Reaction:R-SSC-5696839] MTHFD1L dimer ligates HCOOH to THF to form 10-formyl-THF - Sus scrofa [Reaction:R-BTA-5696839] MTHFD1L dimer ligates HCOOH to THF to form 10-formyl-THF - Bos taurus [Reaction:R-CFA-5696839] MTHFD1L dimer ligates HCOOH to THF to form 10-formyl-THF - Canis familiaris [Reaction:R-RNO-5696839] MTHFD1L dimer ligates HCOOH to THF to form 10-formyl-THF - Rattus norvegicus [Reaction:R-MMU-5696839] MTHFD1L dimer ligates HCOOH to THF to form 10-formyl-THF - Mus musculus
output	[SimpleEntity:R-ALL-5389850] 10-formyl-THF [mitochondrial matrix] [SimpleEntity:R-ALL-113581] ADP [mitochondrial matrix] [SimpleEntity:R-ALL-113548] Pi [mitochondrial matrix]
releaseDate	2015-09-22
reverseReaction	[Reaction:R-HSA-6801456] MTHFD1L transforms 10-formyl-THF to HCOOH and THF
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:6785241] D'Eustachio, Peter, 2015-06-26
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-5696839
summation	[Summation:5696847] All C1-tetrahydrofolate (C1-THF) synthases characterised to ...
updateTrackers	[UpdateTracker:9783791] Update Tracker - [Reaction:5696839] MTHFD1L dimer ligates HCOOH to THF to form 10-formyl-THF - v55:[add_removeInput, modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9783791] Update Tracker - [Reaction:5696839] MTHFD1L dimer ligates HCOOH to THF to form 10-formyl-THF - v55:[add_removeInput, modifyText]
(hasEvent)	[Pathway:R-HSA-196757] Metabolism of folate and pterines
(precedingEvent)	[Reaction:R-HSA-6801328] MTHFD2, D2L oxidise 5,10-methylene-THF to 5,10-methenyl-THF

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