Reactome | FPGS-2 transforms 5-methyl-THF to 5-methyl-THFPG

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FPGS-2 transforms 5-methyl-THF to 5-methyl-THFPG Show undefined attributes

catalystActivity	[CatalystActivity:197957] tetrahydrofolylpolyglutamate synthase activity of FPGS-2 [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:200727] D'Eustachio, P, 2007-07-23 20:23:04
dbId	200681
displayName	FPGS-2 transforms 5-methyl-THF to 5-methyl-THFPG
eventOf	[Pathway:R-HSA-196757] Metabolism of folate and pterines - Homo sapiens
followingEvent	[Reaction:R-HSA-174374] MTR transfers CH3 from MeCbl to HCYS - Homo sapiens
input	[SimpleEntity:R-ALL-200665] 5-methyl-THF [cytosol] 5 × [SimpleEntity:R-ALL-113592] ATP [cytosol] 5 × [SimpleEntity:R-ALL-29404] L-Glu [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:197962] Expression cloning of a human cDNA encoding folylpoly(gamma-glutamate) synthetase and determination of its primary structure [LiteratureReference:200690] Purification and properties of human cytosolic folylpoly-gamma-glutamate synthetase and organization, localization, and differential splicing of its gene
maxDepth	1
modified	[InstanceEdit:11080360] Weiser, Joel, 2026-03-16
name	FPGS-2 transforms 5-methyl-THF to 5-methyl-THFPG Conversion of cytosolic 5-methyltetrahydrofolate (5-methylTHF) to 5-methylTHF-polyglutamate
orthologousEvent	[Reaction:R-RNO-200681] FPGS-2 transforms 5-methyl-THF to 5-methyl-THFPG - Rattus norvegicus [Reaction:R-SCE-200681] FPGS-2 transforms 5-methyl-THF to 5-methyl-THFPG - Saccharomyces cerevisiae [Reaction:R-SPO-200681] FPGS-2 transforms 5-methyl-THF to 5-methyl-THFPG - Schizosaccharomyces pombe [Reaction:R-DDI-200681] FPGS-2 transforms 5-methyl-THF to 5-methyl-THFPG - Dictyostelium discoideum [Reaction:R-CEL-200681] FPGS-2 transforms 5-methyl-THF to 5-methyl-THFPG - Caenorhabditis elegans [Reaction:R-DME-200681] FPGS-2 transforms 5-methyl-THF to 5-methyl-THFPG - Drosophila melanogaster [Reaction:R-GGA-200681] FPGS-2 transforms 5-methyl-THF to 5-methyl-THFPG - Gallus gallus [Reaction:R-XTR-200681] FPGS-2 transforms 5-methyl-THF to 5-methyl-THFPG - Xenopus tropicalis [Reaction:R-DRE-200681] FPGS-2 transforms 5-methyl-THF to 5-methyl-THFPG - Danio rerio [Reaction:R-SSC-200681] FPGS-2 transforms 5-methyl-THF to 5-methyl-THFPG - Sus scrofa [Reaction:R-BTA-200681] FPGS-2 transforms 5-methyl-THF to 5-methyl-THFPG - Bos taurus [Reaction:R-CFA-200681] FPGS-2 transforms 5-methyl-THF to 5-methyl-THFPG - Canis familiaris [Reaction:R-MMU-200681] FPGS-2 transforms 5-methyl-THF to 5-methyl-THFPG - Mus musculus
output	[SimpleEntity:R-ALL-174404] 5-methyl-THFPG [cytosol] 5 × [SimpleEntity:R-ALL-29370] ADP [cytosol] 5 × [SimpleEntity:R-ALL-29372] Pi [cytosol]
precedingEvent	[Reaction:R-HSA-200652] SLC19A1 transports 5-methyl-THF from extracellular region to cytosol - Homo sapiens
releaseDate	2007-08-21
reviewStatus	[ReviewStatus:9821382] five stars
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-200681
summation	[Summation:200744] Cytosolic folylpolyglutamate synthase catalyzes the reaction...

Referrals

(hasEvent)	[Pathway:R-HSA-196757] Metabolism of folate and pterines
(precedingEvent)	[Reaction:R-HSA-174374] MTR transfers CH3 from MeCbl to HCYS