Reactome | SLC46A1 transports FOLA from extracellular region to cytosol

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SLC46A1 transports FOLA from extracellular region to cytosol Show undefined attributes

catalystActivity	[CatalystActivity:200706] folic acid:proton symporter activity of SLC46A1 [plasma membrane]
catalystActivityReference	[CatalystActivityReference:9928938] folic acid:proton symporter activity of SLC46A1 [plasma membrane] Identification of an intestinal folate transporter and the molecular basis for hereditary folate malabsorption
category	transition
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:200727] D'Eustachio, P, 2007-07-23 20:23:04
crossReference	[DatabaseIdentifier:12667640] RHEA:70159
dbId	200729
displayName	SLC46A1 transports FOLA from extracellular region to cytosol
eventOf	[Pathway:R-HSA-196757] Metabolism of folate and pterines - Homo sapiens
followingEvent	[Reaction:R-HSA-197963] DHFR2 reduces FOLA to DHF - Homo sapiens [Reaction:R-HSA-9709098] DHFR dimer reduces FOLA to DHF - Homo sapiens
input	[SimpleEntity:R-ALL-200716] FOLA [extracellular region] [SimpleEntity:R-ALL-351626] H+ [extracellular region]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:200690] Purification and properties of human cytosolic folylpoly-gamma-glutamate synthetase and organization, localization, and differential splicing of its gene [LiteratureReference:200704] Identification of an intestinal folate transporter and the molecular basis for hereditary folate malabsorption [LiteratureReference:9928933] Cloning and functional characterization of the proton-coupled electrogenic folate transporter and analysis of its expression in retinal cell types
maxDepth	1
modified	[InstanceEdit:11080360] Weiser, Joel, 2026-03-16
name	SLC46A1 transports FOLA from extracellular region to cytosol Extracellular folate import across the plasma membrane
orthologousEvent	[Reaction:R-RNO-200729] SLC46A1 transports FOLA from extracellular region to cytosol - Rattus norvegicus [Reaction:R-SCE-200729] SLC46A1 transports FOLA from extracellular region to cytosol - Saccharomyces cerevisiae [Reaction:R-SPO-200729] SLC46A1 transports FOLA from extracellular region to cytosol - Schizosaccharomyces pombe [Reaction:R-CEL-200729] SLC46A1 transports FOLA from extracellular region to cytosol - Caenorhabditis elegans [Reaction:R-DME-200729] SLC46A1 transports FOLA from extracellular region to cytosol - Drosophila melanogaster [Reaction:R-GGA-200729] SLC46A1 transports FOLA from extracellular region to cytosol - Gallus gallus [Reaction:R-XTR-200729] SLC46A1 transports FOLA from extracellular region to cytosol - Xenopus tropicalis [Reaction:R-DRE-200729] SLC46A1 transports FOLA from extracellular region to cytosol - Danio rerio [Reaction:R-SSC-200729] SLC46A1 transports FOLA from extracellular region to cytosol - Sus scrofa [Reaction:R-BTA-200729] SLC46A1 transports FOLA from extracellular region to cytosol - Bos taurus [Reaction:R-CFA-200729] SLC46A1 transports FOLA from extracellular region to cytosol - Canis familiaris [Reaction:R-MMU-200729] SLC46A1 transports FOLA from extracellular region to cytosol - Mus musculus
output	[SimpleEntity:R-ALL-197965] FOLA [cytosol] [SimpleEntity:R-ALL-70106] H+ [cytosol]
previousReviewStatus	[ReviewStatus:9821385] four stars
releaseDate	2007-08-21
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9929029] Hill, David P, 2024-11-19
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-200729
summation	[Summation:200649] SLC46A1 protein in the plasma membrane mediates the reversib...
updateTrackers	[UpdateTracker:9939736] Update Tracker - [Reaction:200729] SLC46A1 transports FOLA from extracellular region to cytosol - v92:[modifyText, removeInput, removeLiteratureReference, removeOutput]

Referrals

(updatedInstance)	[UpdateTracker:9939736] Update Tracker - [Reaction:200729] SLC46A1 transports FOLA from extracellular region to cytosol - v92:[modifyText, removeInput, removeLiteratureReference, removeOutput]
(hasEvent)	[Pathway:R-HSA-196757] Metabolism of folate and pterines
(precedingEvent)	[Reaction:R-HSA-197963] DHFR2 reduces FOLA to DHF [Reaction:R-HSA-9709098] DHFR dimer reduces FOLA to DHF
(reverseReaction)	[Reaction:R-HSA-200646] Cytosolic folate export across the plasma membrane

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