Reactome | Metabolism of folate and pterines

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Metabolism of folate and pterines Show undefined attributes

created	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
dbId	10911574
displayName	Metabolism of folate and pterines
eventOf	[Pathway:R-DME-196849] Metabolism of water-soluble vitamins and cofactors - Drosophila melanogaster
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:25846] folic acid metabolic process
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-DME-200729] SLC46A1 transports FOLA from extracellular region to cytosol - Drosophila melanogaster [Reaction:R-DME-200646] Cytosolic folate export across the plasma membrane - Drosophila melanogaster [Reaction:R-DME-200652] SLC19A1 transports 5-methyl-THF from extracellular region to cytosol - Drosophila melanogaster [Reaction:R-DME-197963] DHFR2 reduces FOLA to DHF - Drosophila melanogaster [Reaction:R-DME-9709098] DHFR dimer reduces FOLA to DHF - Drosophila melanogaster [Reaction:R-DME-9709109] DHFR dimer binds DHFR inhibitors - Drosophila melanogaster [Reaction:R-DME-197972] DHF is reduced to tetrahydrofolate (THF) - Drosophila melanogaster [Reaction:R-DME-197958] FPGS-2 transforms THF to THFPG - Drosophila melanogaster [Reaction:R-DME-200681] FPGS-2 transforms 5-methyl-THF to 5-methyl-THFPG - Drosophila melanogaster [Reaction:R-DME-200680] SLC25A32 transports THF from cytosol to mitochondrial matrix - Drosophila melanogaster [Reaction:R-DME-200720] SLC25A32 transports THF from mitochondrial matrix to cytosol - Drosophila melanogaster [Reaction:R-DME-200682] Mitochondrial FPGS-1 transforms THF to THFPG - Drosophila melanogaster [Reaction:R-DME-5696839] MTHFD1L dimer ligates HCOOH to THF to form 10-formyl-THF - Drosophila melanogaster [Reaction:R-DME-200711] MTHFD1 dimer ligates HCOOH to THFPG to form 10-formyl-THFPG - Drosophila melanogaster [Reaction:R-DME-200661] MTHFD1 dimer transforms 10-formyl-THFPG to 5,10-methenyl-THFPG - Drosophila melanogaster [Reaction:R-DME-200718] MTHFD1 dimer dehydrogenates 5,10-methenyl-THFPG to 5,10-methylene-THFPG - Drosophila melanogaster [Reaction:R-DME-200735] SHMT1 tetramer transfers hydroxymethyl group to THFPG to form 5,10-methylene-THFPG - Drosophila melanogaster [Reaction:R-DME-200676] MTHFR dimer reduces 5,10-methylene-THFPG to 5-methyl-THFPG - Drosophila melanogaster [Reaction:R-DME-200651] 5,10-methyleneTHF polyglutamate + glycine <=> tetrahydrofolate polyglutamate (THF polyglutamate) + serine - Drosophila melanogaster [Reaction:R-DME-200644] 5,10-methyleneTHF polyglutamate + NADP+ <=> 5,10-methenylTHF polyglutamate + NADPH + H+ - Drosophila melanogaster [Reaction:R-DME-200740] 5,10-methenylTHF polyglutamate + H2O <=> 10-formylTHF polyglutamate - Drosophila melanogaster [Reaction:R-DME-6808496] ALDH1L1 dehydrogenates 10-formyl-THFPG to THFPG - Drosophila melanogaster [Reaction:R-DME-6801328] MTHFD2, D2L oxidise 5,10-methylene-THF to 5,10-methenyl-THF - Drosophila melanogaster [Reaction:R-DME-6801462] MTHFD2, D2L oxidise 5,10-methenyl-THF to 10-formyl-THF - Drosophila melanogaster [Reaction:R-DME-6808487] ALDH1L2 dehydrogenates 10-formyl-THFPG to THFPG - Drosophila melanogaster [Reaction:R-DME-6801456] MTHFD1L transforms 10-formyl-THF to HCOOH and THF - Drosophila melanogaster [Reaction:R-DME-6801342] MTHFS transforms 5-formyl-THFPG to 5,10-methenyl-THFPG - Drosophila melanogaster
inferredFrom	[Pathway:R-HSA-196757] Metabolism of folate and pterines - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	Metabolism of folate and pterines
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:56210] Drosophila melanogaster
stId	R-DME-196757
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DME-196849] Metabolism of water-soluble vitamins and cofactors
(inferredTo)	[Pathway:R-HSA-196757] Metabolism of folate and pterines

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