Reactome | Mitochondrial FPGS-1 transforms THF to THFPG

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Mitochondrial FPGS-1 transforms THF to THFPG Show undefined attributes

catalystActivity	[CatalystActivity:200730] tetrahydrofolylpolyglutamate synthase activity of FPGS-1 [mitochondrial matrix]
category	transition
compartment	[Compartment:5460] mitochondrial matrix
created	[InstanceEdit:200727] D'Eustachio, P, 2007-07-23 20:23:04
dbId	200682
displayName	Mitochondrial FPGS-1 transforms THF to THFPG
eventOf	[Pathway:R-HSA-196757] Metabolism of folate and pterines - Homo sapiens
input	6 × [SimpleEntity:R-ALL-113593] ATP [mitochondrial matrix] 6 × [SimpleEntity:R-ALL-113552] L-Glu [mitochondrial matrix] [SimpleEntity:R-ALL-200671] THF [mitochondrial matrix]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:197962] Expression cloning of a human cDNA encoding folylpoly(gamma-glutamate) synthetase and determination of its primary structure [LiteratureReference:200690] Purification and properties of human cytosolic folylpoly-gamma-glutamate synthetase and organization, localization, and differential splicing of its gene
modified	[InstanceEdit:10901498] Wright, Adam, 2024-03-08
name	Mitochondrial FPGS-1 transforms THF to THFPG Conversion of mitochondrial THF to THF-polyglutamate
orthologousEvent	[Reaction:R-SCE-200682] Mitochondrial FPGS-1 transforms THF to THFPG - Saccharomyces cerevisiae [Reaction:R-SPO-200682] Mitochondrial FPGS-1 transforms THF to THFPG - Schizosaccharomyces pombe [Reaction:R-DDI-200682] Mitochondrial FPGS-1 transforms THF to THFPG - Dictyostelium discoideum [Reaction:R-CEL-200682] Mitochondrial FPGS-1 transforms THF to THFPG - Caenorhabditis elegans [Reaction:R-DME-200682] Mitochondrial FPGS-1 transforms THF to THFPG - Drosophila melanogaster [Reaction:R-GGA-200682] Mitochondrial FPGS-1 transforms THF to THFPG - Gallus gallus [Reaction:R-XTR-200682] Mitochondrial FPGS-1 transforms THF to THFPG - Xenopus tropicalis [Reaction:R-DRE-200682] Mitochondrial FPGS-1 transforms THF to THFPG - Danio rerio [Reaction:R-SSC-200682] Mitochondrial FPGS-1 transforms THF to THFPG - Sus scrofa [Reaction:R-BTA-200682] Mitochondrial FPGS-1 transforms THF to THFPG - Bos taurus [Reaction:R-CFA-200682] Mitochondrial FPGS-1 transforms THF to THFPG - Canis familiaris [Reaction:R-RNO-200682] Mitochondrial FPGS-1 transforms THF to THFPG - Rattus norvegicus [Reaction:R-MMU-200682] Mitochondrial FPGS-1 transforms THF to THFPG - Mus musculus
output	6 × [SimpleEntity:R-ALL-113581] ADP [mitochondrial matrix] 6 × [SimpleEntity:R-ALL-113548] Pi [mitochondrial matrix] [SimpleEntity:R-ALL-200679] THFPG [mitochondrial matrix]
precedingEvent	[Reaction:R-HSA-200680] SLC25A32 transports THF from cytosol to mitochondrial matrix - Homo sapiens
releaseDate	2007-08-21
reviewStatus	[ReviewStatus:9821382] five stars
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-200682
summation	[Summation:200637] Mitochondrial folylpolyglutamate synthase catalyzes the reac...

Referrals

(hasEvent)

[Pathway:R-HSA-196757] Metabolism of folate and pterines