Reactome | FOLR2 binds FOLA

Schema > Reaction > Entries

FOLR2 binds FOLA Show undefined attributes

authored	[InstanceEdit:8940132] Jassal, Bijay, 2016-09-23
catalystActivity	[CatalystActivity:9954163] folic acid receptor activity of FOLR2 [plasma membrane]
catalystActivityReference	[CatalystActivityReference:9954164] folic acid receptor activity of FOLR2 [plasma membrane] Studies of the role of a particulate folate-binding protein in the uptake of 5-methyltetrahydrofolate by cultured human KB cells
category	transition
compartment	[Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:8940132] Jassal, Bijay, 2016-09-23
dbId	8940134
displayName	FOLR2 binds FOLA
edited	[InstanceEdit:8940132] Jassal, Bijay, 2016-09-23
eventOf	[Pathway:R-HSA-196757] Metabolism of folate and pterines - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-8942344] FOLR2 transports FOLA from extracellular region to cytosol - Homo sapiens
input	[SimpleEntity:R-ALL-200716] FOLA [extracellular region] [EntityWithAccessionedSequence:R-HSA-8940133] FOLR2 [plasma membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:8940113] Homologous membrane folate binding proteins in human placenta: cloning and sequence of a cDNA [LiteratureReference:8940120] Structures of human folate receptors reveal biological trafficking states and diversity in folate and antifolate recognition [LiteratureReference:8940121] Studies of the role of a particulate folate-binding protein in the uptake of 5-methyltetrahydrofolate by cultured human KB cells
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	FOLR2 binds FOLA
orthologousEvent	[Reaction:R-GGA-8940134] FOLR2 binds FOLA - Gallus gallus [Reaction:R-DRE-8940134] FOLR2 binds FOLA - Danio rerio [Reaction:R-SSC-8940134] FOLR2 binds FOLA - Sus scrofa [Reaction:R-BTA-8940134] FOLR2 binds FOLA - Bos taurus [Reaction:R-CFA-8940134] FOLR2 binds FOLA - Canis familiaris [Reaction:R-RNO-8940134] FOLR2 binds FOLA - Rattus norvegicus [Reaction:R-MMU-8940134] FOLR2 binds FOLA - Mus musculus
output	[Complex:R-HSA-8940118] FOLR2:FOLA [plasma membrane]
previousReviewStatus	[ReviewStatus:9821385] four stars
releaseDate	2016-12-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8942222] D'Eustachio, Peter, 2016-10-11 [InstanceEdit:9962972] Hill, David P, 2025-08-12
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-8940134
summation	[Summation:8940361] The folate receptor beta (FOLR2, FBP) (Ratnam et al. 1989) b...
updateTrackers	[UpdateTracker:9964647] Update Tracker - [Reaction:8940134] FOLR2 binds FOLA - v94:[removeCatalystActivity]

Referrals

(updatedInstance)	[UpdateTracker:9964647] Update Tracker - [Reaction:8940134] FOLR2 binds FOLA - v94:[removeCatalystActivity]
(hasEvent)	[Pathway:R-HSA-196757] Metabolism of folate and pterines
(precedingEvent)	[BlackBoxEvent:R-HSA-8942344] FOLR2 transports FOLA from extracellular region to cytosol