Reactome | Metabolism of folate and pterines

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Metabolism of folate and pterines Show undefined attributes

created	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
dbId	10826307
displayName	Metabolism of folate and pterines
eventOf	[Pathway:R-GGA-196849] Metabolism of water-soluble vitamins and cofactors - Gallus gallus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:25846] folic acid metabolic process
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-GGA-8940134] FOLR2 binds FOLA - Gallus gallus [BlackBoxEvent:R-GGA-8942344] FOLR2 transports FOLA from extracellular region to cytosol - Gallus gallus [Reaction:R-GGA-200729] SLC46A1 transports FOLA from extracellular region to cytosol - Gallus gallus [Reaction:R-GGA-200646] Cytosolic folate export across the plasma membrane - Gallus gallus [Reaction:R-GGA-200652] SLC19A1 transports 5-methyl-THF from extracellular region to cytosol - Gallus gallus [Reaction:R-GGA-197963] DHFR2 reduces FOLA to DHF - Gallus gallus [Reaction:R-GGA-9709098] DHFR dimer reduces FOLA to DHF - Gallus gallus [Reaction:R-GGA-9709109] DHFR dimer binds DHFR inhibitors - Gallus gallus [Reaction:R-GGA-197972] DHF is reduced to tetrahydrofolate (THF) - Gallus gallus [Reaction:R-GGA-197958] FPGS-2 transforms THF to THFPG - Gallus gallus [Reaction:R-GGA-200681] FPGS-2 transforms 5-methyl-THF to 5-methyl-THFPG - Gallus gallus [Reaction:R-GGA-200680] SLC25A32 transports THF from cytosol to mitochondrial matrix - Gallus gallus [Reaction:R-GGA-200720] SLC25A32 transports THF from mitochondrial matrix to cytosol - Gallus gallus [Reaction:R-GGA-200682] Mitochondrial FPGS-1 transforms THF to THFPG - Gallus gallus [Reaction:R-GGA-5696839] MTHFD1L dimer ligates HCOOH to THF to form 10-formyl-THF - Gallus gallus [Reaction:R-GGA-200711] MTHFD1 dimer ligates HCOOH to THFPG to form 10-formyl-THFPG - Gallus gallus [Reaction:R-GGA-200661] MTHFD1 dimer transforms 10-formyl-THFPG to 5,10-methenyl-THFPG - Gallus gallus [Reaction:R-GGA-200718] MTHFD1 dimer dehydrogenates 5,10-methenyl-THFPG to 5,10-methylene-THFPG - Gallus gallus [Reaction:R-GGA-200735] SHMT1 tetramer transfers hydroxymethyl group to THFPG to form 5,10-methylene-THFPG - Gallus gallus [Reaction:R-GGA-200676] MTHFR dimer reduces 5,10-methylene-THFPG to 5-methyl-THFPG - Gallus gallus [Reaction:R-GGA-200651] 5,10-methyleneTHF polyglutamate + glycine <=> tetrahydrofolate polyglutamate (THF polyglutamate) + serine - Gallus gallus [Reaction:R-GGA-200644] 5,10-methyleneTHF polyglutamate + NADP+ <=> 5,10-methenylTHF polyglutamate + NADPH + H+ - Gallus gallus [Reaction:R-GGA-200740] 5,10-methenylTHF polyglutamate + H2O <=> 10-formylTHF polyglutamate - Gallus gallus [Reaction:R-GGA-6801328] MTHFD2, D2L oxidise 5,10-methylene-THF to 5,10-methenyl-THF - Gallus gallus [Reaction:R-GGA-6801462] MTHFD2, D2L oxidise 5,10-methenyl-THF to 10-formyl-THF - Gallus gallus [Reaction:R-GGA-6808487] ALDH1L2 dehydrogenates 10-formyl-THFPG to THFPG - Gallus gallus [Reaction:R-GGA-6801456] MTHFD1L transforms 10-formyl-THF to HCOOH and THF - Gallus gallus [Reaction:R-GGA-6801342] MTHFS transforms 5-formyl-THFPG to 5,10-methenyl-THFPG - Gallus gallus
inferredFrom	[Pathway:R-HSA-196757] Metabolism of folate and pterines - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	Metabolism of folate and pterines
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:49591] Gallus gallus
stId	R-GGA-196757
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-GGA-196849] Metabolism of water-soluble vitamins and cofactors
(inferredTo)	[Pathway:R-HSA-196757] Metabolism of folate and pterines

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