Reactome | MTHFD1 dimer ligates HCOOH to THFPG to form 10-formyl-THFPG

Schema > Reaction > Entries

MTHFD1 dimer ligates HCOOH to THFPG to form 10-formyl-THFPG Show undefined attributes

catalystActivity	[CatalystActivity:200692] formate-tetrahydrofolate ligase activity of MTHFD1 dimer [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:200727] D'Eustachio, P, 2007-07-23 20:23:04
dbId	200711
displayName	MTHFD1 dimer ligates HCOOH to THFPG to form 10-formyl-THFPG
eventOf	[Pathway:R-HSA-196757] Metabolism of folate and pterines - Homo sapiens
followingEvent	[Reaction:R-HSA-200661] MTHFD1 dimer transforms 10-formyl-THFPG to 5,10-methenyl-THFPG - Homo sapiens [Reaction:R-HSA-6808496] ALDH1L1 dehydrogenates 10-formyl-THFPG to THFPG - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [SimpleEntity:R-ALL-29460] HCOOH [cytosol] [SimpleEntity:R-ALL-197969] THFPG [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:200643] C1-Tetrahydrofolate synthase from rabbit liver. Structural and kinetic properties of the enzyme and its two domains. [LiteratureReference:200726] Primary structure of a human trifunctional enzyme. Isolation of a cDNA encoding methylenetetrahydrofolate dehydrogenase-methenyltetrahydrofolate cyclohydrolase-formyltetrahydrofolate synthetase.
maxDepth	1
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	MTHFD1 dimer ligates HCOOH to THFPG to form 10-formyl-THFPG THF polyglutamate + formate + ATP => 10-formylTHF polyglutamate + ADP + orthophosphate
orthologousEvent	[Reaction:R-PFA-200711] MTHFD1 dimer ligates HCOOH to THFPG to form 10-formyl-THFPG - Plasmodium falciparum [Reaction:R-SCE-200711] MTHFD1 dimer ligates HCOOH to THFPG to form 10-formyl-THFPG - Saccharomyces cerevisiae [Reaction:R-SPO-200711] MTHFD1 dimer ligates HCOOH to THFPG to form 10-formyl-THFPG - Schizosaccharomyces pombe [Reaction:R-DDI-200711] MTHFD1 dimer ligates HCOOH to THFPG to form 10-formyl-THFPG - Dictyostelium discoideum [Reaction:R-CEL-200711] MTHFD1 dimer ligates HCOOH to THFPG to form 10-formyl-THFPG - Caenorhabditis elegans [Reaction:R-DME-200711] MTHFD1 dimer ligates HCOOH to THFPG to form 10-formyl-THFPG - Drosophila melanogaster [Reaction:R-GGA-200711] MTHFD1 dimer ligates HCOOH to THFPG to form 10-formyl-THFPG - Gallus gallus [Reaction:R-XTR-200711] MTHFD1 dimer ligates HCOOH to THFPG to form 10-formyl-THFPG - Xenopus tropicalis [Reaction:R-DRE-200711] MTHFD1 dimer ligates HCOOH to THFPG to form 10-formyl-THFPG - Danio rerio [Reaction:R-SSC-200711] MTHFD1 dimer ligates HCOOH to THFPG to form 10-formyl-THFPG - Sus scrofa [Reaction:R-BTA-200711] MTHFD1 dimer ligates HCOOH to THFPG to form 10-formyl-THFPG - Bos taurus [Reaction:R-CFA-200711] MTHFD1 dimer ligates HCOOH to THFPG to form 10-formyl-THFPG - Canis familiaris [Reaction:R-RNO-200711] MTHFD1 dimer ligates HCOOH to THFPG to form 10-formyl-THFPG - Rattus norvegicus [Reaction:R-MMU-200711] MTHFD1 dimer ligates HCOOH to THFPG to form 10-formyl-THFPG - Mus musculus
output	[SimpleEntity:R-ALL-111353] 10-formyl-THFPG [cytosol] [SimpleEntity:R-ALL-29370] ADP [cytosol] [SimpleEntity:R-ALL-29372] Pi [cytosol]
precedingEvent	[Reaction:R-HSA-197958] FPGS-2 transforms THF to THFPG - Homo sapiens
releaseDate	2007-08-21
reviewStatus	[ReviewStatus:9821382] five stars
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-200711
summation	[Summation:200688] The formate-tetrahydrofolate ligase activity of the trifunct...

Referrals

(hasEvent)	[Pathway:R-HSA-196757] Metabolism of folate and pterines
(precedingEvent)	[Reaction:R-HSA-6808496] ALDH1L1 dehydrogenates 10-formyl-THFPG to THFPG [Reaction:R-HSA-200661] MTHFD1 dimer transforms 10-formyl-THFPG to 5,10-methenyl-THFPG