Reactome | 5,10-methenylTHF polyglutamate + H2O <=> 10-formylTHF polyglutamate

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5,10-methenylTHF polyglutamate + H2O <=> 10-formylTHF polyglutamate Show undefined attributes

catalystActivity	[CatalystActivity:200745] methenyltetrahydrofolate cyclohydrolase activity of MTHFD1 dimer [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:200727] D'Eustachio, P, 2007-07-23 20:23:04
dbId	200740
displayName	5,10-methenylTHF polyglutamate + H2O <=> 10-formylTHF polyglutamate
eventOf	[Pathway:R-HSA-196757] Metabolism of folate and pterines - Homo sapiens
followingEvent	[Reaction:R-HSA-6808496] ALDH1L1 dehydrogenates 10-formyl-THFPG to THFPG - Homo sapiens
input	[SimpleEntity:R-ALL-200640] 5,10-methenyl-THFPG [cytosol] [SimpleEntity:R-ALL-29356] H2O [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:200643] C1-Tetrahydrofolate synthase from rabbit liver. Structural and kinetic properties of the enzyme and its two domains. [LiteratureReference:200726] Primary structure of a human trifunctional enzyme. Isolation of a cDNA encoding methylenetetrahydrofolate dehydrogenase-methenyltetrahydrofolate cyclohydrolase-formyltetrahydrofolate synthetase.
maxDepth	1
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	5,10-methenylTHF polyglutamate + H2O <=> 10-formylTHF polyglutamate
orthologousEvent	[Reaction:R-RNO-200740] 5,10-methenylTHF polyglutamate + H2O <=> 10-formylTHF polyglutamate - Rattus norvegicus [Reaction:R-PFA-200740] 5,10-methenylTHF polyglutamate + H2O <=> 10-formylTHF polyglutamate - Plasmodium falciparum [Reaction:R-SCE-200740] 5,10-methenylTHF polyglutamate + H2O <=> 10-formylTHF polyglutamate - Saccharomyces cerevisiae [Reaction:R-SPO-200740] 5,10-methenylTHF polyglutamate + H2O <=> 10-formylTHF polyglutamate - Schizosaccharomyces pombe [Reaction:R-DDI-200740] 5,10-methenylTHF polyglutamate + H2O <=> 10-formylTHF polyglutamate - Dictyostelium discoideum [Reaction:R-CEL-200740] 5,10-methenylTHF polyglutamate + H2O <=> 10-formylTHF polyglutamate - Caenorhabditis elegans [Reaction:R-DME-200740] 5,10-methenylTHF polyglutamate + H2O <=> 10-formylTHF polyglutamate - Drosophila melanogaster [Reaction:R-GGA-200740] 5,10-methenylTHF polyglutamate + H2O <=> 10-formylTHF polyglutamate - Gallus gallus [Reaction:R-XTR-200740] 5,10-methenylTHF polyglutamate + H2O <=> 10-formylTHF polyglutamate - Xenopus tropicalis [Reaction:R-DRE-200740] 5,10-methenylTHF polyglutamate + H2O <=> 10-formylTHF polyglutamate - Danio rerio [Reaction:R-SSC-200740] 5,10-methenylTHF polyglutamate + H2O <=> 10-formylTHF polyglutamate - Sus scrofa [Reaction:R-BTA-200740] 5,10-methenylTHF polyglutamate + H2O <=> 10-formylTHF polyglutamate - Bos taurus [Reaction:R-CFA-200740] 5,10-methenylTHF polyglutamate + H2O <=> 10-formylTHF polyglutamate - Canis familiaris [Reaction:R-MMU-200740] 5,10-methenylTHF polyglutamate + H2O <=> 10-formylTHF polyglutamate - Mus musculus
output	[SimpleEntity:R-ALL-111353] 10-formyl-THFPG [cytosol]
precedingEvent	[Reaction:R-HSA-200644] 5,10-methyleneTHF polyglutamate + NADP+ <=> 5,10-methenylTHF polyglutamate + NADPH + H+ - Homo sapiens
releaseDate	2007-08-21
reverseReaction	[Reaction:R-HSA-200661] MTHFD1 dimer transforms 10-formyl-THFPG to 5,10-methenyl-THFPG
reviewStatus	[ReviewStatus:9821382] five stars
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-200740
summation	[Summation:200707] The methenyltetrahydrofolate cyclohydrolase activity of the ...

Referrals

(hasEvent)	[Pathway:R-HSA-196757] Metabolism of folate and pterines
(precedingEvent)	[Reaction:R-HSA-6808496] ALDH1L1 dehydrogenates 10-formyl-THFPG to THFPG

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