Reactome | PXLP-K280-SHMT2 tetramer transfers CH2OH group to Gly to form L-Ser

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PXLP-K280-SHMT2 tetramer transfers CH2OH group to Gly to form L-Ser Show undefined attributes

authored	[InstanceEdit:5694479] Jassal, Bijay, 2015-05-21
catalystActivity	[CatalystActivity:5694152] glycine hydroxymethyltransferase activity of PXLP-K280-SHMT2 tetramer [mitochondrial inner membrane]
category	transition
compartment	[Compartment:70616] mitochondrial inner membrane [Compartment:5460] mitochondrial matrix
created	[InstanceEdit:5694122] Jassal, Bijay, 2015-05-21
dbId	5694137
displayName	PXLP-K280-SHMT2 tetramer transfers CH2OH group to Gly to form L-Ser
edited	[InstanceEdit:5694479] Jassal, Bijay, 2015-05-21
eventOf	[Pathway:R-HSA-196757] Metabolism of folate and pterines - Homo sapiens
input	[SimpleEntity:R-ALL-5693984] 5,10-methylene-THF [mitochondrial matrix] [SimpleEntity:R-ALL-159549] Gly [mitochondrial matrix] [SimpleEntity:R-ALL-113521] H2O [mitochondrial matrix]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:5694111] Identification of a de novo thymidylate biosynthesis pathway in mammalian mitochondria
modified	[InstanceEdit:10931649] Wright, Adam, 2024-03-08
name	PXLP-K280-SHMT2 tetramer transfers CH2OH group to Gly to form L-Ser
orthologousEvent	[Reaction:R-PFA-5694137] PXLP-K280-SHMT2 tetramer transfers CH2OH group to Gly to form L-Ser - Plasmodium falciparum [Reaction:R-DDI-5694137] PXLP-K280-SHMT2 tetramer transfers CH2OH group to Gly to form L-Ser - Dictyostelium discoideum [Reaction:R-XTR-5694137] PXLP-K280-SHMT2 tetramer transfers CH2OH group to Gly to form L-Ser - Xenopus tropicalis [Reaction:R-DRE-5694137] PXLP-K280-SHMT2 tetramer transfers CH2OH group to Gly to form L-Ser - Danio rerio [Reaction:R-SSC-5694137] PXLP-K280-SHMT2 tetramer transfers CH2OH group to Gly to form L-Ser - Sus scrofa [Reaction:R-BTA-5694137] PXLP-K280-SHMT2 tetramer transfers CH2OH group to Gly to form L-Ser - Bos taurus [Reaction:R-CFA-5694137] PXLP-K280-SHMT2 tetramer transfers CH2OH group to Gly to form L-Ser - Canis familiaris [Reaction:R-RNO-5694137] PXLP-K280-SHMT2 tetramer transfers CH2OH group to Gly to form L-Ser - Rattus norvegicus [Reaction:R-MMU-5694137] PXLP-K280-SHMT2 tetramer transfers CH2OH group to Gly to form L-Ser - Mus musculus
output	[SimpleEntity:R-ALL-379732] L-Ser [mitochondrial matrix] [SimpleEntity:R-ALL-200671] THF [mitochondrial matrix]
precedingEvent	[Reaction:R-HSA-6797913] SARDH:FAD oxidatively demethylates SARC to Gly - Homo sapiens
releaseDate	2015-09-22
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:6785241] D'Eustachio, Peter, 2015-06-26
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-5694137
summation	[Summation:5694125] Mitochondrial serine hydroxymethyltransferase (SHMT2) contri...

Referrals

(hasEvent)

[Pathway:R-HSA-196757] Metabolism of folate and pterines