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PPP1CB [cytosol]
Stable Identifier
R-HSA-163405
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
PP1CB, Serine/threonine protein phosphatase PP1-beta catalytic subunit , PP-1B
Locations in the PathwayBrowser
Expand all
Circadian Clock (Homo sapiens)
CSNK1E,CSNK1D phosphorylate CRY and PER proteins (Homo sapiens)
PP1 catalytic subunit [cytosol] (Homo sapiens)
PPP1CB [cytosol] (Homo sapiens)
Disease (Homo sapiens)
Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
Oncogenic MAPK signaling (Homo sapiens)
Signaling by MRAS-complex mutants (Homo sapiens)
Mutant MRAS:SHOC2:PPP1CC complexes dephosphorylate inactive RAFs (Homo sapiens)
PPP1CB, PPP1CB [cytosol] (Homo sapiens)
PPP1CB [cytosol] (Homo sapiens)
mutant MRAS:SHOC2:PP1 complexes [plasma membrane] (Homo sapiens)
S-GCC MRAS mutants:GTP:SHOC2:PP1 [plasma membrane] (Homo sapiens)
PPP1CB, PPP1CB [cytosol] (Homo sapiens)
PPP1CB [cytosol] (Homo sapiens)
S-GCC MRAS:GTP:SHOC2 S2G:PP1 [plasma membrane] (Homo sapiens)
PPP1CB, PPP1CB [cytosol] (Homo sapiens)
PPP1CB [cytosol] (Homo sapiens)
SHOC2 M173I disrupts the SHOC2:MRAS:PP1 complex (Homo sapiens)
PPP1CB, PPP1CB [cytosol] (Homo sapiens)
PPP1CB [cytosol] (Homo sapiens)
SHOC2 M173I:MRAS:PP1 [plasma membrane] (Homo sapiens)
PPP1CB, PPP1CB [cytosol] (Homo sapiens)
PPP1CB [cytosol] (Homo sapiens)
Metabolism (Homo sapiens)
Metabolism of lipids (Homo sapiens)
Triglyceride metabolism (Homo sapiens)
Triglyceride catabolism (Homo sapiens)
phosphorylated perilipin + H2O -> perilipin + orthophosphate (Homo sapiens)
PP1 catalytic subunit [cytosol] (Homo sapiens)
PPP1CB [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
MAPK family signaling cascades (Homo sapiens)
MAPK1/MAPK3 signaling (Homo sapiens)
RAF/MAP kinase cascade (Homo sapiens)
RAF activation (Homo sapiens)
MRAS:SHOC2:PPP1CC dephosphorylates inactive RAFs (Homo sapiens)
PPP1CB, PPP1CB [cytosol] (Homo sapiens)
PPP1CB [cytosol] (Homo sapiens)
S-GCC MRAS:GTP:SHOC2:PP1 [plasma membrane] (Homo sapiens)
PPP1CB, PPP1CB [cytosol] (Homo sapiens)
PPP1CB [cytosol] (Homo sapiens)
Signaling by Rho GTPases (Homo sapiens)
RHO GTPase Effectors (Homo sapiens)
RHO GTPases Activate ROCKs (Homo sapiens)
Myosin phosphatase dephosphorylates myosin regulatory light chain (Homo sapiens)
Myosin phosphatase [cytosol] (Homo sapiens)
PPP1CB [cytosol] (Homo sapiens)
Myosin phosphatase inactivation by ROCK (Homo sapiens)
Myosin phosphatase [cytosol] (Homo sapiens)
PPP1CB [cytosol] (Homo sapiens)
p-T696,S852-MYPT1-Myosin Phosphatase [cytosol] (Homo sapiens)
PPP1CB [cytosol] (Homo sapiens)
RHO GTPases activate CIT (Homo sapiens)
Activated CIT phosphorylates MRLCs (Homo sapiens)
Myosin phosphatase [cytosol] (Homo sapiens)
PPP1CB [cytosol] (Homo sapiens)
RHO GTPases activate PAKs (Homo sapiens)
MYLK (MLCK) phosphorylates MRLCs of the non-muscle myosin II complex (Homo sapiens)
Myosin phosphatase [cytosol] (Homo sapiens)
PPP1CB [cytosol] (Homo sapiens)
Myosin phosphatase dephosphorylates myosin regulatory light chain (Homo sapiens)
Myosin phosphatase [cytosol] (Homo sapiens)
PPP1CB [cytosol] (Homo sapiens)
PAK1 phosphorylates myosin phosphatase (Homo sapiens)
Myosin phosphatase [cytosol] (Homo sapiens)
PPP1CB [cytosol] (Homo sapiens)
p-T696-PPP1R12A-Myosin phosphatase [cytosol] (Homo sapiens)
PPP1CB [cytosol] (Homo sapiens)
RHO GTPases activate PKNs (Homo sapiens)
Myosin phosphatase dephosphorylates myosin regulatory light chain (Homo sapiens)
Myosin phosphatase [cytosol] (Homo sapiens)
PPP1CB [cytosol] (Homo sapiens)
p-T38-PPP1R14A binds MLCP (Homo sapiens)
MLCP:p-T38-PPP1R14A [cytosol] (Homo sapiens)
Myosin phosphatase [cytosol] (Homo sapiens)
PPP1CB [cytosol] (Homo sapiens)
Myosin phosphatase [cytosol] (Homo sapiens)
PPP1CB [cytosol] (Homo sapiens)
Signaling by TGFB family members (Homo sapiens)
Signaling by TGF-beta Receptor Complex (Homo sapiens)
TGF-beta receptor signaling activates SMADs (Homo sapiens)
Downregulation of TGF-beta receptor signaling (Homo sapiens)
PP1 dephosphorylates TGFBR1 (Homo sapiens)
GADD34:PP1 [cytosol] (Homo sapiens)
PP1 catalytic subunit [cytosol] (Homo sapiens)
PPP1CB [cytosol] (Homo sapiens)
TGFB1:p-TGFBR:I-SMAD7:GADD34:PP1:ZFYVE9 [early endosome membrane] (Homo sapiens)
GADD34:PP1 [cytosol] (Homo sapiens)
PP1 catalytic subunit [cytosol] (Homo sapiens)
PPP1CB [cytosol] (Homo sapiens)
SMAD7 recruits GADD34:PP1 to phosphorylated TGFBR (Homo sapiens)
GADD34:PP1 [cytosol] (Homo sapiens)
PP1 catalytic subunit [cytosol] (Homo sapiens)
PPP1CB [cytosol] (Homo sapiens)
TGFB1:p-TGFBR:I-SMAD7:GADD34:PP1:ZFYVE9 [early endosome membrane] (Homo sapiens)
GADD34:PP1 [cytosol] (Homo sapiens)
PP1 catalytic subunit [cytosol] (Homo sapiens)
PPP1CB [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P62140 PPP1CB
Gene Names
PPP1CB
Chain
initiator methionine:1, chain:2-327
Reference Genes
BioGPS Gene:5500 PPP1CB
COSMIC (genes):PPP1CB PPP1CB
CTD Gene:5500 PPP1CB
dbSNP Gene:5500 PPP1CB
ENSEMBL:ENSG00000213639 PPP1CB
HGNC:9282 PPP1CB
KEGG Gene (Homo sapiens):5500 PPP1CB
Monarch:5500 PPP1CB
NCBI Gene:5500 PPP1CB
OMIM:600590 PPP1CB
Reference Transcript
RefSeq:NM_206876.1 PPP1CB
RefSeq:NM_002709.2 PPP1CB
Other Identifiers
0000380026
11725614_s_at
11725615_a_at
11725616_at
11746720_a_at
11757308_s_at
16878522
201407_s_at
201408_at
201409_s_at
2475210
2475211
2475212
2475213
2475214
2475226
2475228
2475232
2475233
2475237
2475241
2475242
2475244
2475245
2475246
2475247
2475248
2475249
2475250
2475251
5500
78737_at
8041122
A_24_P396720
A_24_P405298
GE60066
GO:0000086
GO:0000164
GO:0000228
GO:0000278
GO:0000784
GO:0003674
GO:0004721
GO:0004722
GO:0005515
GO:0005575
GO:0005576
GO:0005615
GO:0005622
GO:0005634
GO:0005654
GO:0005694
GO:0005730
GO:0005737
GO:0005829
GO:0005886
GO:0005925
GO:0005975
GO:0005977
GO:0005979
GO:0005981
GO:0006091
GO:0006464
GO:0006470
GO:0007049
GO:0007155
GO:0008150
GO:0009056
GO:0009058
GO:0016787
GO:0016791
GO:0017018
GO:0019899
GO:0019901
GO:0030155
GO:0032922
GO:0032991
GO:0042587
GO:0042752
GO:0043153
GO:0043167
GO:0043226
GO:0044281
GO:0046872
GO:0048511
GO:0050115
GO:0051301
GO:0070062
GO:0072357
Hs.21537.0.S2_3p_a_at
Hs.21537.0.S4_3p_s_at
ILMN_1736942
ILMN_2405018
ILMN_2405023
PH_hs_0001870
TC02004955.hg
X80910_at
g4506004_3p_a_at
Participant Of
hasComponent
Myosin phosphatase [cytosol]
p-T696,S852-MYPT1-Myosin Phosphatase [cytosol]
p-T696-PPP1R12A-Myosin phosphatase [cytosol]
hasMember
PP1 catalytic subunit [cytosol]
PPP1CB, PPP1CB [cytosol]
Other forms of this molecule
PPP1CB [nucleoplasm]
PPP1CB P49R [cytosol]
PPP1CB A56P [cytosol]
Inferred To
Ppp1cb [cytosol] (Mus musculus)
Ppp1cb [cytosol] (Rattus norvegicus)
gsp-1 [cytosol] (Caenorhabditis elegans)
Homologues of PPP1CB [cytosol] (Danio rerio)
flw [cytosol] (Drosophila melanogaster)
PPP1CA [cytosol] (Gallus gallus)
ppp1cbl [cytosol] (Danio rerio)
ppp1cb [cytosol] (Danio rerio)
ppp1cb [cytosol] (Xenopus tropicalis)
Cross References
RefSeq
NP_002700.1
,
NP_996759.1
Target Pathogen
5b2801b2be737e35a6de73ef
,
5b2801b2be737e35a6deb191
OpenTargets
ENSG00000213639
IntEnz
3.1.3.53
,
3.1.3.16
HPA
ENSG00000213639-PPP1CB
GeneCards
P62140
Ensembl
ENSP00000351298
,
ENST00000395366
,
ENSP00000296122
,
ENST00000296122
,
ENST00000358506
,
ENSP00000378769
,
ENSG00000213639
PRO
P62140
Orphanet
24822
HMDB Protein
HMDBP01775
Interactors (13)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q8WUF5 PPP1R13L
1
PPP1R13L [nucleoplasm]
(R-HSA-6799738)
0.83
6
UniProt:Q9UQK1 PPP1R3C
2
PPP1R3C [cytosol]
(R-HSA-3777102)
K48polyUb-PPP1R3C [cytosol]
(R-HSA-3781005)
0.782
9
UniProt:Q5UIP0 RIF1
1
RIF1 [nucleoplasm]
(R-HSA-480742)
0.69
4
UniProt:P62136 PPP1CA
1
PPP1CA [cytosol]
(R-HSA-163525)
0.638
3
UniProt:Q9BZF9 UACA
1
UACA [cytosol]
(R-HSA-6804636)
0.597
3
UniProt:P38398 BRCA1
27
SUMO1-K109-BRCA1 [nucleoplasm]
(R-HSA-2997644)
SUMO2,3-BRCA1 [nucleoplasm]
(R-HSA-2997624)
BRCA1 C64R [nucleoplasm]
(R-HSA-9700907)
BRCA1 C61G [nucleoplasm]
(R-HSA-9700890)
BRCA1 C39Y [nucleoplasm]
(R-HSA-9700938)
BRCA1 H41R [nucleoplasm]
(R-HSA-9700921)
BRCA1 C24R [nucleoplasm]
(R-HSA-9663198)
BRCA1 H41A [nucleoplasm]
(R-HSA-9700927)
BRCA1 M18T [nucleoplasm]
(R-HSA-9700911)
BRCA1 C47G [nucleoplasm]
(R-HSA-9700941)
BRCA1 C64G [nucleoplasm]
(R-HSA-9700899)
BRCA1 C44F [nucleoplasm]
(R-HSA-9700944)
BRCA1 T37R [nucleoplasm]
(R-HSA-9700934)
BRCA1 C27A [nucleoplasm]
(R-HSA-9700916)
BRCA1 H41Q [nucleoplasm]
(R-HSA-9700923)
BRCA1 Q12Tfs*5 [nucleoplasm]
(R-HSA-9700953)
BRCA1 E23Afs*18 [nucleoplasm]
(R-HSA-9700959)
BRCA1 C61Y [nucleoplasm]
(R-HSA-9700894)
BRCA1 C24F [nucleoplasm]
(R-HSA-9663206)
BRCA1 E23Rfs*18 [nucleoplasm]
(R-HSA-9700960)
BRCA1 E23Vfs*17 [nucleoplasm]
(R-HSA-9700967)
p-S988,S1387,S1423,S1524,S1547-BRCA1 [nucleoplasm]
(R-HSA-5683800)
K6PolyUb,p-S988,S1387,S1423,S1524,S1547-BRCA1 [nucleoplasm]
(R-HSA-9707298)
BRCA1 [nucleoplasm]
(R-HSA-50949)
K6PolyUb-BRCA1 [nucleoplasm]
(R-HSA-9701022)
K6PolyUb,p-S1387,S1423,S1524,S1547-BRCA1 [nucleoplasm]
(R-HSA-9707290)
p-S1387,S1423,S1524,S1547-BRCA1 [nucleoplasm]
(R-HSA-75234)
0.581
3
UniProt:Q9NX63 CHCHD3
3
CHCHD3 [mitochondrial intermembrane space]
(R-HSA-8874907)
CHCHD3 (MIC19) [mitochondrial inner membrane]
(R-HSA-8949583)
4xHC-CHCHD3 [mitochondrial intermembrane space]
(R-HSA-8874910)
0.556
3
UniProt:Q8NI77 KIF18A
1
KIF18A [cytosol]
(R-HSA-376239)
0.508
2
UniProt:P19388 POLR2E
2
POLR2E [cytosol]
(R-HSA-1964438)
POLR2E [nucleoplasm]
(R-HSA-83713)
0.508
2
UniProt:O08785 Clock
2
p-S-Clock [nucleoplasm]
(R-MMU-508670)
Clock [cytosol]
(R-MMU-508720)
0.508
2
UniProt:Q9UBK9 UXT
1
UXT [nucleoplasm]
(R-HSA-9007484)
0.508
2
UniProt:P19338 NCL
1
NCL [nucleoplasm]
(R-HSA-6791213)
0.463
2
UniProt:Q14974 KPNB1
5
KPNB1 [nucleoplasm]
(R-HSA-180714)
KPNB1 [cytosol]
(R-HSA-180733)
KPNB1 [specific granule lumen]
(R-HSA-6799646)
KPNB1 [extracellular region]
(R-HSA-6806306)
KPNB1 [ficolin-1-rich granule lumen]
(R-HSA-6800978)
0.462
2
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