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Active FLT3 [plasma membrane]
Stable Identifier
R-HSA-9604751
Type
Complex
Species
Homo sapiens
Compartment
plasma membrane
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
FLT3 signaling in disease (Homo sapiens)
FLT3 signaling by CBL mutants (Homo sapiens)
CBL mutants don't ubiquitinate FLT3 (Homo sapiens)
Active FLT3 [plasma membrane] (Homo sapiens)
Active FLT3:CBL mutants [plasma membrane] (Homo sapiens)
Active FLT3 [plasma membrane] (Homo sapiens)
PI3K/AKT Signaling in Cancer (Homo sapiens)
Constitutive Signaling by Aberrant PI3K in Cancer (Homo sapiens)
PI3K inhibitors block PI3K catalytic activity (Homo sapiens)
PI3K Inhibitors:PI3K [cytosol] (Homo sapiens)
PI3K mutants,Activator:PI3K [plasma membrane] (Homo sapiens)
Activator:PI3K [plasma membrane] (Homo sapiens)
Active FLT3:GRB2:p-Y GAB2:PI3K [plasma membrane] (Homo sapiens)
Active FLT3:GRB2:p-Y-GAB2:PIK3R1 [cytosol] (Homo sapiens)
Active FLT3:GRB2:p-Y-GAB2 [plasma membrane] (Homo sapiens)
Active FLT3: GRB2 [plasma membrane] (Homo sapiens)
Active FLT3 [plasma membrane] (Homo sapiens)
PI3K mutants,Activator:PI3K [plasma membrane] (Homo sapiens)
Activator:PI3K [plasma membrane] (Homo sapiens)
Active FLT3:GRB2:p-Y GAB2:PI3K [plasma membrane] (Homo sapiens)
Active FLT3:GRB2:p-Y-GAB2:PIK3R1 [cytosol] (Homo sapiens)
Active FLT3:GRB2:p-Y-GAB2 [plasma membrane] (Homo sapiens)
Active FLT3: GRB2 [plasma membrane] (Homo sapiens)
Active FLT3 [plasma membrane] (Homo sapiens)
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
FLT3 Signaling (Homo sapiens)
Active FLT3 binds PTPN11 (Homo sapiens)
Active FLT3 [plasma membrane] (Homo sapiens)
Active FLT3:PTPN11 [plasma membrane] (Homo sapiens)
Active FLT3 [plasma membrane] (Homo sapiens)
Active FLT3 binds to GRAP2 (Homo sapiens)
Active FLT3 [plasma membrane] (Homo sapiens)
active FLT3:GRAP2 [plasma membrane] (Homo sapiens)
Active FLT3 [plasma membrane] (Homo sapiens)
Active FLT3 binds to GRB10 (Homo sapiens)
Active FLT3 [plasma membrane] (Homo sapiens)
active FLT3:GRB10 [plasma membrane] (Homo sapiens)
Active FLT3 [plasma membrane] (Homo sapiens)
Active FLT3 dimer binds GRB2 (Homo sapiens)
Active FLT3 [plasma membrane] (Homo sapiens)
Active FLT3: GRB2 [plasma membrane] (Homo sapiens)
Active FLT3 [plasma membrane] (Homo sapiens)
Active FLT3 phosphorylates CDKN1B (Homo sapiens)
Active FLT3 [plasma membrane] (Homo sapiens)
Active FLT3:GRB2 binds GAB2 (Homo sapiens)
Active FLT3: GRB2 [plasma membrane] (Homo sapiens)
Active FLT3 [plasma membrane] (Homo sapiens)
Active FLT3:GRB2:GAB2 [plasma membrane] (Homo sapiens)
Active FLT3: GRB2 [plasma membrane] (Homo sapiens)
Active FLT3 [plasma membrane] (Homo sapiens)
Active FLT3:GRB2 binds SOS1 (Homo sapiens)
Active FLT3: GRB2 [plasma membrane] (Homo sapiens)
Active FLT3 [plasma membrane] (Homo sapiens)
Active FLT3:GRB2:SOS1 [plasma membrane] (Homo sapiens)
Active FLT3: GRB2 [plasma membrane] (Homo sapiens)
Active FLT3 [plasma membrane] (Homo sapiens)
Active FLT3:GRB2:p-GAB2:PIK3R1 binds PIK3CA (Homo sapiens)
Active FLT3:GRB2:p-Y GAB2:PI3K [plasma membrane] (Homo sapiens)
Active FLT3:GRB2:p-Y-GAB2:PIK3R1 [cytosol] (Homo sapiens)
Active FLT3:GRB2:p-Y-GAB2 [plasma membrane] (Homo sapiens)
Active FLT3: GRB2 [plasma membrane] (Homo sapiens)
Active FLT3 [plasma membrane] (Homo sapiens)
Active FLT3:GRB2:p-Y-GAB2:PIK3R1 [cytosol] (Homo sapiens)
Active FLT3:GRB2:p-Y-GAB2 [plasma membrane] (Homo sapiens)
Active FLT3: GRB2 [plasma membrane] (Homo sapiens)
Active FLT3 [plasma membrane] (Homo sapiens)
Active FLT3:GRB2:p-Y-GAB2 binds PIK3R1 (Homo sapiens)
Active FLT3:GRB2:p-Y-GAB2 [plasma membrane] (Homo sapiens)
Active FLT3: GRB2 [plasma membrane] (Homo sapiens)
Active FLT3 [plasma membrane] (Homo sapiens)
Active FLT3:GRB2:p-Y-GAB2:PIK3R1 [cytosol] (Homo sapiens)
Active FLT3:GRB2:p-Y-GAB2 [plasma membrane] (Homo sapiens)
Active FLT3: GRB2 [plasma membrane] (Homo sapiens)
Active FLT3 [plasma membrane] (Homo sapiens)
Active FLT3:GRB2:p-Y-GAB2 binds PTPN11 (Homo sapiens)
Active FLT3:GRB2:p-Y-GAB2 [plasma membrane] (Homo sapiens)
Active FLT3: GRB2 [plasma membrane] (Homo sapiens)
Active FLT3 [plasma membrane] (Homo sapiens)
Active FLT3:GRB2:p-Y-GAB2:PTPN11 [plasma membrane] (Homo sapiens)
Active FLT3:GRB2:p-Y-GAB2 [plasma membrane] (Homo sapiens)
Active FLT3: GRB2 [plasma membrane] (Homo sapiens)
Active FLT3 [plasma membrane] (Homo sapiens)
Active FLT3:p-Y GRB10:PIK3R1 binds PIK3CA (Homo sapiens)
active FLT3:p-Y GRB10:PI3K [plasma membrane] (Homo sapiens)
Active FLT3 [plasma membrane] (Homo sapiens)
active FLT3:p-Y GRB10:PIK3R1 [plasma membrane] (Homo sapiens)
Active FLT3 [plasma membrane] (Homo sapiens)
Active FLT3:p-Y-GRB10 binds PIK3R1 (Homo sapiens)
active FLT3:p-Y GRB10 [plasma membrane] (Homo sapiens)
Active FLT3 [plasma membrane] (Homo sapiens)
active FLT3:p-Y GRB10:PIK3R1 [plasma membrane] (Homo sapiens)
Active FLT3 [plasma membrane] (Homo sapiens)
FLT3 phosphorylates GRB10 (Homo sapiens)
active FLT3:GRB10 [plasma membrane] (Homo sapiens)
Active FLT3 [plasma membrane] (Homo sapiens)
active FLT3:p-Y GRB10 [plasma membrane] (Homo sapiens)
Active FLT3 [plasma membrane] (Homo sapiens)
FLT3 signaling through SRC family kinases (Homo sapiens)
Active FLT3 binds FYN (Homo sapiens)
Active FLT3 [plasma membrane] (Homo sapiens)
Active FLT3:FYN [plasma membrane] (Homo sapiens)
Active FLT3 [plasma membrane] (Homo sapiens)
Active FLT3 binds HCK (Homo sapiens)
Active FLT3 [plasma membrane] (Homo sapiens)
Active FLT3:HCK [plasma membrane] (Homo sapiens)
Active FLT3 [plasma membrane] (Homo sapiens)
Active FLT3 binds to LCK (Homo sapiens)
Active FLT3 [plasma membrane] (Homo sapiens)
active FLT3:LCK [plasma membrane] (Homo sapiens)
Active FLT3 [plasma membrane] (Homo sapiens)
Active FLT3 binds to SYK (Homo sapiens)
Active FLT3 [plasma membrane] (Homo sapiens)
active FLT3:SYK [plasma membrane] (Homo sapiens)
Active FLT3 [plasma membrane] (Homo sapiens)
FLT3LG dimer:FLT3 dimer autophosphorylates (Homo sapiens)
Active FLT3 [plasma membrane] (Homo sapiens)
GAB2 in Active FLT3:GRB2:GAB2 is phosphorylated (Homo sapiens)
Active FLT3:GRB2:GAB2 [plasma membrane] (Homo sapiens)
Active FLT3: GRB2 [plasma membrane] (Homo sapiens)
Active FLT3 [plasma membrane] (Homo sapiens)
Active FLT3:GRB2:p-Y-GAB2 [plasma membrane] (Homo sapiens)
Active FLT3: GRB2 [plasma membrane] (Homo sapiens)
Active FLT3 [plasma membrane] (Homo sapiens)
Negative regulation of FLT3 (Homo sapiens)
Active FLT3 binds to ABL2 (Homo sapiens)
Active FLT3 [plasma membrane] (Homo sapiens)
active FLT3:ABL2 [plasma membrane] (Homo sapiens)
Active FLT3 [plasma membrane] (Homo sapiens)
Active FLT3 binds to CBL (Homo sapiens)
Active FLT3 [plasma membrane] (Homo sapiens)
active FLT3:CBL [plasma membrane] (Homo sapiens)
Active FLT3 [plasma membrane] (Homo sapiens)
active FLT3:SH2B3 [plasma membrane] (Homo sapiens)
Active FLT3 [plasma membrane] (Homo sapiens)
active FLT3:SLA [plasma membrane] (Homo sapiens)
Active FLT3 [plasma membrane] (Homo sapiens)
active FLT3:SLA2 [plasma membrane] (Homo sapiens)
Active FLT3 [plasma membrane] (Homo sapiens)
Active FLT3 binds to CSK (Homo sapiens)
Active FLT3 [plasma membrane] (Homo sapiens)
active FLT3:CSK [plasma membrane] (Homo sapiens)
Active FLT3 [plasma membrane] (Homo sapiens)
Active FLT3 binds to SH2B3 (Homo sapiens)
Active FLT3 [plasma membrane] (Homo sapiens)
active FLT3:SH2B3 [plasma membrane] (Homo sapiens)
Active FLT3 [plasma membrane] (Homo sapiens)
Active FLT3 binds to SLA (Homo sapiens)
Active FLT3 [plasma membrane] (Homo sapiens)
active FLT3:SLA [plasma membrane] (Homo sapiens)
Active FLT3 [plasma membrane] (Homo sapiens)
Active FLT3 binds to SLA2 (Homo sapiens)
Active FLT3 [plasma membrane] (Homo sapiens)
active FLT3:SLA2 [plasma membrane] (Homo sapiens)
Active FLT3 [plasma membrane] (Homo sapiens)
Active FLT3 binds to SOCS2 (Homo sapiens)
Active FLT3 [plasma membrane] (Homo sapiens)
active FLT3:SOCS2 [plasma membrane] (Homo sapiens)
Active FLT3 [plasma membrane] (Homo sapiens)
Active FLT3 binds to SOCS6 (Homo sapiens)
Active FLT3 [plasma membrane] (Homo sapiens)
active FLT3:SOCS6 [plasma membrane] (Homo sapiens)
Active FLT3 [plasma membrane] (Homo sapiens)
FLT3 phosphorylates CBL (Homo sapiens)
active FLT3:CBL [plasma membrane] (Homo sapiens)
Active FLT3 [plasma membrane] (Homo sapiens)
active FLT3:pY-CBL [plasma membrane] (Homo sapiens)
Active FLT3 [plasma membrane] (Homo sapiens)
PTPRJ dephosphorylates active FLT3 (Homo sapiens)
Active FLT3 [plasma membrane] (Homo sapiens)
Ubiquitination of FLT3 (Homo sapiens)
Active FLT3 [plasma membrane] (Homo sapiens)
FLT3 E3 ubiquitin ligases [plasma membrane] (Homo sapiens)
active FLT3:SOCS2 [plasma membrane] (Homo sapiens)
Active FLT3 [plasma membrane] (Homo sapiens)
active FLT3:SOCS6 [plasma membrane] (Homo sapiens)
Active FLT3 [plasma membrane] (Homo sapiens)
active FLT3:pY-CBL [plasma membrane] (Homo sapiens)
Active FLT3 [plasma membrane] (Homo sapiens)
SOS1-mediated nucleotide exchange of RAS downstream of FLT3 (Homo sapiens)
Active FLT3:GRB2:SOS1 [plasma membrane] (Homo sapiens)
Active FLT3: GRB2 [plasma membrane] (Homo sapiens)
Active FLT3 [plasma membrane] (Homo sapiens)
STAT5 Activation (Homo sapiens)
Activator phosphorylates STAT5 (Homo sapiens)
Activators of STAT5:STAT5 [cytosol] (Homo sapiens)
Activators of STAT5 [cytosol] (Homo sapiens)
Active FLT3:GRB2:p-Y-GAB2:PTPN11 [plasma membrane] (Homo sapiens)
Active FLT3:GRB2:p-Y-GAB2 [plasma membrane] (Homo sapiens)
Active FLT3: GRB2 [plasma membrane] (Homo sapiens)
Active FLT3 [plasma membrane] (Homo sapiens)
Active FLT3:PTPN11 [plasma membrane] (Homo sapiens)
Active FLT3 [plasma membrane] (Homo sapiens)
Activators of STAT5:p-STAT5 [cytosol] (Homo sapiens)
Activators of STAT5 [cytosol] (Homo sapiens)
Active FLT3:GRB2:p-Y-GAB2:PTPN11 [plasma membrane] (Homo sapiens)
Active FLT3:GRB2:p-Y-GAB2 [plasma membrane] (Homo sapiens)
Active FLT3: GRB2 [plasma membrane] (Homo sapiens)
Active FLT3 [plasma membrane] (Homo sapiens)
Active FLT3:PTPN11 [plasma membrane] (Homo sapiens)
Active FLT3 [plasma membrane] (Homo sapiens)
Activators bind STAT5 (Homo sapiens)
Activators of STAT5 [cytosol] (Homo sapiens)
Active FLT3:GRB2:p-Y-GAB2:PTPN11 [plasma membrane] (Homo sapiens)
Active FLT3:GRB2:p-Y-GAB2 [plasma membrane] (Homo sapiens)
Active FLT3: GRB2 [plasma membrane] (Homo sapiens)
Active FLT3 [plasma membrane] (Homo sapiens)
Active FLT3:PTPN11 [plasma membrane] (Homo sapiens)
Active FLT3 [plasma membrane] (Homo sapiens)
Activators of STAT5:STAT5 [cytosol] (Homo sapiens)
Activators of STAT5 [cytosol] (Homo sapiens)
Active FLT3:GRB2:p-Y-GAB2:PTPN11 [plasma membrane] (Homo sapiens)
Active FLT3:GRB2:p-Y-GAB2 [plasma membrane] (Homo sapiens)
Active FLT3: GRB2 [plasma membrane] (Homo sapiens)
Active FLT3 [plasma membrane] (Homo sapiens)
Active FLT3:PTPN11 [plasma membrane] (Homo sapiens)
Active FLT3 [plasma membrane] (Homo sapiens)
p-STAT5 dissociates from activator:STAT5 complex (Homo sapiens)
Activators of STAT5 [cytosol] (Homo sapiens)
Active FLT3:GRB2:p-Y-GAB2:PTPN11 [plasma membrane] (Homo sapiens)
Active FLT3:GRB2:p-Y-GAB2 [plasma membrane] (Homo sapiens)
Active FLT3: GRB2 [plasma membrane] (Homo sapiens)
Active FLT3 [plasma membrane] (Homo sapiens)
Active FLT3:PTPN11 [plasma membrane] (Homo sapiens)
Active FLT3 [plasma membrane] (Homo sapiens)
Activators of STAT5:p-STAT5 [cytosol] (Homo sapiens)
Activators of STAT5 [cytosol] (Homo sapiens)
Active FLT3:GRB2:p-Y-GAB2:PTPN11 [plasma membrane] (Homo sapiens)
Active FLT3:GRB2:p-Y-GAB2 [plasma membrane] (Homo sapiens)
Active FLT3: GRB2 [plasma membrane] (Homo sapiens)
Active FLT3 [plasma membrane] (Homo sapiens)
Active FLT3:PTPN11 [plasma membrane] (Homo sapiens)
Active FLT3 [plasma membrane] (Homo sapiens)
Signal Transduction (Homo sapiens)
Intracellular signaling by second messengers (Homo sapiens)
PIP3 activates AKT signaling (Homo sapiens)
Negative regulation of the PI3K/AKT network (Homo sapiens)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Homo sapiens)
PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
Activator:PI3K [plasma membrane] (Homo sapiens)
Active FLT3:GRB2:p-Y GAB2:PI3K [plasma membrane] (Homo sapiens)
Active FLT3:GRB2:p-Y-GAB2:PIK3R1 [cytosol] (Homo sapiens)
Active FLT3:GRB2:p-Y-GAB2 [plasma membrane] (Homo sapiens)
Active FLT3: GRB2 [plasma membrane] (Homo sapiens)
Active FLT3 [plasma membrane] (Homo sapiens)
PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
Activator:PI3K [plasma membrane] (Homo sapiens)
Active FLT3:GRB2:p-Y GAB2:PI3K [plasma membrane] (Homo sapiens)
Active FLT3:GRB2:p-Y-GAB2:PIK3R1 [cytosol] (Homo sapiens)
Active FLT3:GRB2:p-Y-GAB2 [plasma membrane] (Homo sapiens)
Active FLT3: GRB2 [plasma membrane] (Homo sapiens)
Active FLT3 [plasma membrane] (Homo sapiens)
MAPK family signaling cascades (Homo sapiens)
MAPK1/MAPK3 signaling (Homo sapiens)
RAF/MAP kinase cascade (Homo sapiens)
RAS GEFs promote RAS nucleotide exchange (Homo sapiens)
RAS GEFs [plasma membrane] (Homo sapiens)
Active FLT3:GRB2:SOS1 [plasma membrane] (Homo sapiens)
Active FLT3: GRB2 [plasma membrane] (Homo sapiens)
Active FLT3 [plasma membrane] (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by Insulin receptor (Homo sapiens)
Insulin receptor signalling cascade (Homo sapiens)
IRS-mediated signalling (Homo sapiens)
PI3K Cascade (Homo sapiens)
PI3K-containing complexes phosphorylate PIP2 to PIP3 (Homo sapiens)
PI3K-containing complexes [cytosol] (Homo sapiens)
Active FLT3:GRB2:p-Y-GAB2:PIK3R1 [cytosol] (Homo sapiens)
Active FLT3:GRB2:p-Y-GAB2 [plasma membrane] (Homo sapiens)
Active FLT3: GRB2 [plasma membrane] (Homo sapiens)
Active FLT3 [plasma membrane] (Homo sapiens)
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) (Homo sapiens)
IGF1R signaling cascade (Homo sapiens)
IRS-related events triggered by IGF1R (Homo sapiens)
IRS-mediated signalling (Homo sapiens)
PI3K Cascade (Homo sapiens)
PI3K-containing complexes phosphorylate PIP2 to PIP3 (Homo sapiens)
PI3K-containing complexes [cytosol] (Homo sapiens)
Active FLT3:GRB2:p-Y-GAB2:PIK3R1 [cytosol] (Homo sapiens)
Active FLT3:GRB2:p-Y-GAB2 [plasma membrane] (Homo sapiens)
Active FLT3: GRB2 [plasma membrane] (Homo sapiens)
Active FLT3 [plasma membrane] (Homo sapiens)
Participants
components
2 x
Autophosphorylated FLT3 [plasma membrane] (Homo sapiens)
FLT3LG dimer [extracellular region] (Homo sapiens)
Participant Of
hasComponent
Active FLT3: GRB2 [plasma membrane]
active FLT3:ABL2 [plasma membrane]
active FLT3:CBL [plasma membrane]
Active FLT3:CBL mutants [plasma membrane]
active FLT3:CSK [plasma membrane]
Active FLT3:FYN [plasma membrane]
active FLT3:GRAP2 [plasma membrane]
active FLT3:GRB10 [plasma membrane]
Active FLT3:HCK [plasma membrane]
active FLT3:LCK [plasma membrane]
active FLT3:p-Y GRB10 [plasma membrane]
active FLT3:p-Y GRB10:PI3K [plasma membrane]
active FLT3:p-Y GRB10:PIK3R1 [plasma membrane]
Active FLT3:PTPN11 [plasma membrane]
active FLT3:pY-CBL [plasma membrane]
active FLT3:SH2B3 [plasma membrane]
active FLT3:SLA [plasma membrane]
active FLT3:SLA2 [plasma membrane]
active FLT3:SOCS2 [plasma membrane]
active FLT3:SOCS6 [plasma membrane]
active FLT3:SYK [plasma membrane]
input
Active FLT3 binds FYN
Active FLT3 binds HCK
Active FLT3 binds PTPN11
Active FLT3 binds to ABL2
Active FLT3 binds to CBL
Active FLT3 binds to CSK
Active FLT3 binds to GRAP2
Active FLT3 binds to GRB10
Active FLT3 binds to LCK
Active FLT3 binds to SH2B3
Active FLT3 binds to SLA
Active FLT3 binds to SLA2
Active FLT3 binds to SOCS2
Active FLT3 binds to SOCS6
Active FLT3 binds to SYK
Active FLT3 dimer binds GRB2
CBL mutants don't ubiquitinate FLT3
PTPRJ dephosphorylates active FLT3
Ubiquitination of FLT3
output
FLT3LG dimer:FLT3 dimer autophosphorylates
Inferred To
Active FLT3 [plasma membrane] (Bos taurus)
Active FLT3 [plasma membrane] (Canis familiaris)
Active FLT3 [plasma membrane] (Danio rerio)
Active FLT3 [plasma membrane] (Gallus gallus)
Active FLT3 [plasma membrane] (Mus musculus)
Active FLT3 [plasma membrane] (Rattus norvegicus)
Active FLT3 [plasma membrane] (Sus scrofa)
Active FLT3 [plasma membrane] (Xenopus tropicalis)
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