Active FLT3 binds to GRAP2

Stable Identifier
R-HSA-9706304
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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GRB2-related adaptor protein 2 (GRAP2, also known as GADS) binds to active FLT3 through Y955 and Y969, overlapping with the FLT3 binding site of GRB2. GRAP2-binding stimulates FLT3 signaling through the AKT, MAP kinase, STAT and p38 pathways. Expression of GRAP2 promotes proliferation and colony formation in cell lines and tumor formation in a mouse xenograft model (Chougule et al, 2016; reviewed in Kazi and Ronnstrand, 2019).

Literature References
PubMed ID Title Journal Year
26895103 Expression of GADS enhances FLT3-induced mitogenic signaling

Kazi, JU, Pietras, K, Cordero, E, Chougule, RA, Moharram, SA, Rönnstrand, L

Oncotarget 2016
31066629 FMS-like Tyrosine Kinase 3/FLT3: From Basic Science to Clinical Implications

Kazi, JU, Rönnstrand, L

Physiol. Rev. 2019
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