Active FLT3 binds to GRAP2

Stable Identifier
R-HSA-9706304
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane, cytosol
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Active FLT3 binds to GRAP2
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

GRB2-related adaptor protein 2 (GRAP2, also known as GADS) binds to active FLT3 through Y955 and Y969, overlapping with the FLT3 binding site of GRB2. GRAP2-binding stimulates FLT3 signaling through the AKT, MAP kinase, STAT and p38 pathways. Expression of GRAP2 promotes proliferation and colony formation in cell lines and tumor formation in a mouse xenograft model (Chougule et al, 2016; reviewed in Kazi and Ronnstrand, 2019).

Literature References
PubMed ID Title Journal Year
26895103 Expression of GADS enhances FLT3-induced mitogenic signaling

Kazi, JU, Pietras, K, Cordero, E, Chougule, RA, Moharram, SA, Rönnstrand, L

Oncotarget 2016
31066629 FMS-like Tyrosine Kinase 3/FLT3: From Basic Science to Clinical Implications

Kazi, JU, Rönnstrand, L

Physiol. Rev. 2019
Participants
Input
Output
Participates
as an event of
Orthologous Events
Active FLT3 binds to GRAP2 (Bos taurus)
Active FLT3 binds to GRAP2 (Canis familiaris)
Active FLT3 binds to GRAP2 (Mus musculus)
Active FLT3 binds to GRAP2 (Rattus norvegicus)
Authored
Rothfels, K  (2020-11-06)
Reviewed
Kazi, JU  (2020-11-06)
Created
Rothfels, K  (2020-11-04)
Cite Us!