Active FLT3 binds to GRAP2

Stable Identifier
R-HSA-9706304
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane, cytosol
ReviewStatus
5/5
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Active FLT3 binds to GRAP2
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GRB2-related adaptor protein 2 (GRAP2, also known as GADS) binds to active FLT3 through Y955 and Y969, overlapping with the FLT3 binding site of GRB2. GRAP2-binding stimulates FLT3 signaling through the AKT, MAP kinase, STAT and p38 pathways. Expression of GRAP2 promotes proliferation and colony formation in cell lines and tumor formation in a mouse xenograft model (Chougule et al, 2016; reviewed in Kazi and Ronnstrand, 2019).
Literature References
PubMed ID Title Journal Year
31066629 FMS-like Tyrosine Kinase 3/FLT3: From Basic Science to Clinical Implications

Kazi, JU, Rönnstrand, L

Physiol. Rev. 2019
26895103 Expression of GADS enhances FLT3-induced mitogenic signaling

Kazi, JU, Pietras, K, Cordero, E, Chougule, RA, Moharram, SA, Rönnstrand, L

Oncotarget 2016
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Orthologous Events
Active FLT3 binds to GRAP2 (Bos taurus)
Active FLT3 binds to GRAP2 (Canis familiaris)
Active FLT3 binds to GRAP2 (Mus musculus)
Active FLT3 binds to GRAP2 (Sus scrofa)
Authored
Rothfels, K  (2020-11-06)
Reviewed
Kazi, JU  (2020-11-06)
Created
Rothfels, K  (2020-11-04)
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