The E3 ubiquitin ligase SOCS2 binds to tyrosine phosphorylated FLT3 through Y589 and Y919. SOCS2 contributes to ubiquitination, internalization and downregulation of active FLT3, consistent with known roles for SOCS family members (Kazi and Ronnstrand, 2013; reviewed in Kazi et al, 2014).
Flores-Morales, A, Kazi, JU, Kabir, NN, Rönnstrand, L
Kazi, JU, Rönnstrand, L
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