Active FLT3 binds to SOCS2

Stable Identifier
R-HSA-9706328
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane, cytosol
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Active FLT3 binds to SOCS2
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The E3 ubiquitin ligase SOCS2 binds to tyrosine phosphorylated FLT3 through Y589 and Y919. SOCS2 contributes to ubiquitination, internalization and downregulation of active FLT3, consistent with known roles for SOCS family members (Kazi and Ronnstrand, 2013; reviewed in Kazi et al, 2014).

Literature References
PubMed ID Title Journal Year
23548639 Suppressor of cytokine signaling 2 (SOCS2) associates with FLT3 and negatively regulates downstream signaling

Kazi, JU, Rönnstrand, L

Mol Oncol 2013
24705897 SOCS proteins in regulation of receptor tyrosine kinase signaling

Flores-Morales, A, Kazi, JU, Kabir, NN, Rönnstrand, L

Cell Mol Life Sci 2014
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Orthologous Events
Active FLT3 binds to SOCS2 (Canis familiaris)
Active FLT3 binds to SOCS2 (Mus musculus)
Active FLT3 binds to SOCS2 (Rattus norvegicus)
Authored
Rothfels, K  (2020-11-06)
Reviewed
Kazi, JU  (2020-11-06)
Created
Rothfels, K  (2020-11-04)
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