Active FLT3 binds to SOCS2

Stable Identifier
R-HSA-9706328
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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The E3 ubiquitin ligase SOCS2 binds to tyrosine phosphorylated FLT3 through Y589 and Y919. SOCS2 contributes to ubiquitination, internalization and downregulation of active FLT3, consistent with known roles for SOCS family members (Kazi and Ronnstrand, 2013; reviewed in Kazi et al, 2014).

Literature References
PubMed ID Title Journal Year
23548639 Suppressor of cytokine signaling 2 (SOCS2) associates with FLT3 and negatively regulates downstream signaling

Kazi, JU, Rönnstrand, L

Mol Oncol 2013
24705897 SOCS proteins in regulation of receptor tyrosine kinase signaling

Kazi, JU, Kabir, NN, Flores-Morales, A, Rönnstrand, L

Cell Mol Life Sci 2014
Participants
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Orthologous Events
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