Reactome | Active FLT3 binds to SH2B3

Active FLT3 binds to SH2B3

Stable Identifier

R-HSA-9706315

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane, cytosol

ReviewStatus

5/5

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SH2B3 (also called LNK) is an adaptor protein that binds to tyrosine phosphorylated FLT3 through at least 3 tyrosine residues, Y572, Y591 and Y919 (Lin et al, 2012). SH3B2 is a known CBL interactor, so may contribute to FLT3 downregulation by promoting the CBL-dependent ubiquitination and internalization of the receptor, although this hasn't been formally demonstrated (Lv et al, 2017; Lin et al, 2012; reviewed in Kazi and Ronnstrand, 2019).

Literature References

PubMed ID	Title	Journal	Year
31066629	FMS-like Tyrosine Kinase 3/FLT3: From Basic Science to Clinical Implications Kazi, JU, Rönnstrand, L	Physiol. Rev.	2019
22942183	Adaptor protein Lnk binds to and inhibits normal and leukemic FLT3 Tabayashi, T, Koren-Michowitz, M, Lin, DC, Kazi, JU, Gery, S, Yin, T, Ding, LW, Koeffler, HP, Stocking, C, Gueller, S, Rönnstrand, L, Bergholz, U	Blood	2012
28611190	CBL family E3 ubiquitin ligases control JAK2 ubiquitination and stability in hematopoietic stem cells and myeloid malignancies Hexner, EO, Cheng, Y, Pillai, V, Rozenova, K, Todd, EA, Riling, CR, Jeschke, GR, Goetz, BT, Lv, K, Donaghy, R, Band, H, Kumar, S, Chandra, V, An, W, Jiang, J, Mohapatra, BC, Tong, W, Langdon, WY, Han, X	Genes Dev	2017