Active FLT3 binds to SH2B3

Stable Identifier
R-HSA-9706315
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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SH2B3 (also called LNK) is an adaptor protein that binds to tyrosine phosphorylated FLT3 through at least 3 tyrosine residues, Y572, Y591 and Y919 (Lin et al, 2012). SH3B2 is a known CBL interactor, so may contribute to FLT3 downregulation by promoting the CBL-dependent ubiquitination and internalization of the receptor, although this hasn't been formally demonstrated (Lv et al, 2017; Lin et al, 2012; reviewed in Kazi and Ronnstrand, 2019).

Literature References
PubMed ID Title Journal Year
22942183 Adaptor protein Lnk binds to and inhibits normal and leukemic FLT3

Lin, DC, Yin, T, Koren-Michowitz, M, Ding, LW, Gueller, S, Gery, S, Tabayashi, T, Bergholz, U, Kazi, JU, Rönnstrand, L, Stocking, C, Koeffler, HP

Blood 2012
31066629 FMS-like Tyrosine Kinase 3/FLT3: From Basic Science to Clinical Implications

Kazi, JU, Rönnstrand, L

Physiol. Rev. 2019
28611190 CBL family E3 ubiquitin ligases control JAK2 ubiquitination and stability in hematopoietic stem cells and myeloid malignancies

Lv, K, Jiang, J, Donaghy, R, Riling, CR, Cheng, Y, Chandra, V, Rozenova, K, An, W, Mohapatra, BC, Goetz, BT, Pillai, V, Han, X, Todd, EA, Jeschke, GR, Langdon, WY, Kumar, S, Hexner, EO, Band, H, Tong, W

Genes Dev 2017
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