Reactome | FLT3LG dimer:FLT3 dimer autophosphorylates

FLT3LG dimer:FLT3 dimer autophosphorylates

Stable Identifier

R-HSA-9604767

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

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FLT3LG dimer:FLT3 dimer autophosphorylates

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Feline McDonough Sarcoma-like tyrosine kinase (FLT3) is a member of the class III tyrosine kinase receptor family. Ligand binding induces conformational changes in FLT3 receptor, which facilitates its dimerization. This process exposes phosphate acceptor sites in the catalytic domain of FLT3. Subsequently, FLT3 autophosphorylates at these sites. Several phosphorylation sites have been reported and there may be more modifications required to fully activate FLT3 (Heiss et al. 2006, Masson et al. 2009, Razumovskaya et al. 2009). Experiments confirming this event were performed in mouse cells.

Literature References

PubMed ID	Title	Journal	Year
19438505	A role of Gab2 association in Flt3 ITD mediated Stat5 phosphorylation and cell survival Masson, K, Liu, T, Khan, R, Sun, J, Rönnstrand, L	Br. J. Haematol.	2009
16684964	Identification of Y589 and Y599 in the juxtamembrane domain of Flt3 as ligand-induced autophosphorylation sites involved in binding of Src family kinases and the protein tyrosine phosphatase SHP2 Heiss, E, Masson, K, Sundberg, C, Pedersen, M, Sun, J, Bengtsson, S, Rönnstrand, L	Blood	2006
19477218	Oncogenic Flt3 receptors display different specificity and kinetics of autophosphorylation Razumovskaya, E, Masson, K, Khan, R, Bengtsson, S, Rönnstrand, L	Exp. Hematol.	2009