FLT3LG dimer:FLT3 dimer autophosphorylates

Stable Identifier
R-HSA-9604767
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
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Feline McDonough Sarcoma-like tyrosine kinase (FLT3) is a member of the class III tyrosine kinase receptor family. Ligand binding induces conformational changes in FLT3 receptor, which facilitates its dimerization. This process exposes phosphate acceptor sites in the catalytic domain of FLT3. Subsequently, FLT3 autophosphorylates at these sites. Several phosphorylation sites have been reported and there may be more modifications required to fully activate FLT3 (Heiss et al. 2006, Masson et al. 2009, Razumovskaya et al. 2009). Experiments confirming this event were performed in mouse cells.

Literature References
PubMed ID Title Journal Year
16684964 Identification of Y589 and Y599 in the juxtamembrane domain of Flt3 as ligand-induced autophosphorylation sites involved in binding of Src family kinases and the protein tyrosine phosphatase SHP2

Heiss, E, Masson, K, Sundberg, C, Pedersen, M, Sun, J, Bengtsson, S, Rönnstrand, L

Blood 2006
19438505 A role of Gab2 association in Flt3 ITD mediated Stat5 phosphorylation and cell survival

Masson, K, Liu, T, Khan, R, Sun, J, Rönnstrand, L

Br. J. Haematol. 2009
19477218 Oncogenic Flt3 receptors display different specificity and kinetics of autophosphorylation

Razumovskaya, E, Masson, K, Khan, R, Bengtsson, S, Rönnstrand, L

Exp. Hematol. 2009
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hasEvent
Catalyst Activity
Catalyst Activity
Title
protein tyrosine kinase activity of FLT3LG dimer:FLT3 dimer [plasma membrane]
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