Active FLT3 binds to SLA

Stable Identifier
R-HSA-9706319
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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SRC-like adaptor protein (SLA, also known as SLAP) binds to tyrosine phosphorylated FLT3 (Kazi and Ronnstrand, 2012). This binding stimulates CBL-dependent FLT3 ubiquitination and internalization. Because SLAP is also known to bind to CBL, SLAP may function as an adaptor protein, bringing CBL to the FLT3 receptor. Direct interaction of CBL and SLAP has not be explicitly demonstrated in the context of FLT3 signaling, however (Dragone et al, 2006; Kazi et al, 2012, reviewed in Kazi and Ronnstrand, 2019). In addition to promoting the internalization of FLT3, SLAP also contributes to downstream signaling through the AKT, MAP kinase and p38 cascades. These roles are not shown in this pathway, however (Kazi et al, 2012).

Literature References
PubMed ID Title Journal Year
31066629 FMS-like Tyrosine Kinase 3/FLT3: From Basic Science to Clinical Implications

Kazi, JU, Rönnstrand, L

Physiol. Rev. 2019
17110436 Src-like adaptor protein (SLAP) regulates B cell receptor levels in a c-Cbl-dependent manner

Dragone, LL, Myers, MD, White, C, Gadwal, S, Sosinowski, T, Gu, H, Weiss, A

Proc Natl Acad Sci U S A 2006
23300935 Src-Like adaptor protein (SLAP) binds to the receptor tyrosine kinase Flt3 and modulates receptor stability and downstream signaling

Kazi, JU, Rönnstrand, L

PLoS One 2012
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