Reactome | Active FLT3 binds to SLA

Active FLT3 binds to SLA

Stable Identifier

R-HSA-9706319

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane, cytosol

ReviewStatus

5/5

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SRC-like adaptor protein (SLA, also known as SLAP) binds to tyrosine phosphorylated FLT3 (Kazi and Ronnstrand, 2012). This binding stimulates CBL-dependent FLT3 ubiquitination and internalization. Because SLAP is also known to bind to CBL, SLAP may function as an adaptor protein, bringing CBL to the FLT3 receptor. Direct interaction of CBL and SLAP has not be explicitly demonstrated in the context of FLT3 signaling, however (Dragone et al, 2006; Kazi et al, 2012, reviewed in Kazi and Ronnstrand, 2019). In addition to promoting the internalization of FLT3, SLAP also contributes to downstream signaling through the AKT, MAP kinase and p38 cascades. These roles are not shown in this pathway, however (Kazi et al, 2012).

Literature References

PubMed ID	Title	Journal	Year
17110436	Src-like adaptor protein (SLAP) regulates B cell receptor levels in a c-Cbl-dependent manner Dragone, LL, White, C, Gadwal, S, Weiss, A, Gu, H, Myers, MD, Sosinowski, T	Proc Natl Acad Sci U S A	2006
31066629	FMS-like Tyrosine Kinase 3/FLT3: From Basic Science to Clinical Implications Kazi, JU, Rönnstrand, L	Physiol. Rev.	2019
23300935	Src-Like adaptor protein (SLAP) binds to the receptor tyrosine kinase Flt3 and modulates receptor stability and downstream signaling Kazi, JU, Rönnstrand, L	PLoS One	2012